ARHGEF28

Gene Name		Rho guanine nucleotide exchange factor (GEF) 28
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane
	Molecular Function	RNA Binding Rho Guanyl-nucleotide Exchange Factor Activity Metal Ion Binding
	Biological Process	Axon Guidance Central Nervous System Neuron Axonogenesis Positive Regulation Of Rho GTPase Activity Intracellular Signal Transduction Ephrin Receptor Signaling Pathway Neurofilament Cytoskeleton Organization
Pathways		EPHB-mediated forward signaling Axon guidance EPH-Ephrin signaling
Drugs
Diseases
GWAS
Protein-protein Interactions		4 interactors: MAPK8IP1 RHOA YWHAE YWHAH
Entrez ID		64283
HPRD ID		15244
Ensembl ID		ENSG00000214944
Uniprot IDs		Q8N1W1
PDB IDs
Enriched GO Terms of Interacting Partners?		Substantia Nigra Development Neural Nucleus Development Midbrain Development Positive Regulation Of Intracellular Transport Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Organelle Organization Regulation Of Intracellular Transport Positive Regulation Of Mitochondrion Organization Intracellular Signal Transduction Action Potential Regulation Of Mitochondrion Organization Regulation Of Establishment Of Protein Localization Negative Regulation Of Cell Morphogenesis Involved In Differentiation Positive Regulation Of Transport Brain Development Regulation Of Protein Localization Negative Regulation Of Neuron Projection Development Head Development Glucocorticoid Catabolic Process Regulation Of Signal Transduction Negative Regulation Of Cell Projection Organization Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Regulation Of Organelle Organization Central Nervous System Development Regulation Of Signaling Negative Regulation Of Peptidyl-serine Dephosphorylation Regulation Of Heart Rate By Hormone Regulation Of Cellular Localization Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Neuron Differentiation Positive Regulation Of Apoptotic Signaling Pathway Skeletal Muscle Satellite Cell Migration Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Membrane Potential Negative Regulation Of Neurogenesis Regulation Of Apoptotic Process Negative Regulation Of Protein Dephosphorylation Apolipoprotein A-I-mediated Signaling Pathway JUN Phosphorylation Cleavage Furrow Formation Regulation Of Cell Death Generation Of Neurons Negative Regulation Of Cell Development Apoptotic Signaling Pathway Neurogenesis
Tagcloud ?		als approx comprehensive copy destabilizing encodes fals familial fus generate guanine heterozygous homozygosity inclusions kb motor mtsod1 neuron nfl premature rgnef rho sals spinal sporadic taqman tls truncated warranted