ARHGEF28 and CTAG1B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ARHGEF28	CTAG1B
Description		Rho guanine nucleotide exchange factor 28	cancer/testis antigen 1B
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane	Cytoplasm
	Molecular Function	RNA Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding	Protein Binding Identical Protein Binding
	Biological Process	Cell Morphogenesis Central Nervous System Neuron Axonogenesis Cell Differentiation Regulation Of Rho Protein Signal Transduction Ephrin Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Neurofilament Cytoskeleton Organization	TRNA Threonylcarbamoyladenosine Metabolic Process
Pathways		EPHB-mediated forward signaling RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle
Drugs
Diseases
GWAS		Age-related hearing impairment ( 34108613) Chin dimples ( 27182965) Gut microbiota relative abundance (unclassified genus belonging to family Ruminococcaceae) ( 33208821) HDL cholesterol ( 30275531) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hodgkin's lymphoma ( 34216518) Mean spheric corpuscular volume ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Vaginal microbiome composition (Shannon diversity index) ( 32723796) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 28448500)
Interacting Genes		8 interacting genes: AKT1 CTAG1A CTAG1B MAPK8IP1 RHOA TARDBP YWHAE YWHAH	81 interacting genes: ACTN3 AIRIM ALOX15B ARHGEF28 ATP1A4 BAG6 BEX1 BEX2 BMF BORCS8 BORCS8-MEF2B C14orf119 CAMSAP1 CCDC116 CCHCR1 CDC37 CDKN2AIPNL CHCHD2 CSTF2T CTAG1A CYTH4 DESI1 FCHSD2 FSD2 GATC GNG13 GPSM3 GTF2I GUCD1 HCK HEMK1 HLA-DRB1 HLA-DRB3 HLA-DRB4 HLA-DRB5 KIF26A KLHL38 LAMTOR1 LNPEP LONRF3 MAGEC1 MEIS2 MGAT5B MSGN1 NAB2 NCS1 NTAQ1 P4HA3 PEF1 PIH1D2 POLM PSMB1 RANBP10 REX1BD RSRC2 RTN4IP1 RUSC1 SEC14L4 SGTA SGTB SIKE1 SMG9 SOHLH1 SPAG8 STRA8 SUOX TCEANC TEPSIN THOC1 TNPO2 TRIB3 TRIM55 TRIM63 TSGA10IP UBE2V1 UBL5 UBQLN1 UBQLN2 USP20 VENTX WWOX
Entrez ID		64283	1485
HPRD ID		15244	02151
Ensembl ID		ENSG00000214944	ENSG00000184033
Uniprot IDs		Q8N1W1	P78358
PDB IDs		6BC0 6BC1	1S9W 2BNQ 2BNR 2F53 2F54 2P5E 2P5W 2PYE 3GJF 3HAE 3KLA 6AT5 6AVF 6AVG 6RP9 6RPA 6RPB 9C3E 9DL1
Enriched GO Terms of Interacting Partners?		Intracellular Receptor Signaling Pathway Substantia Nigra Development Neural Nucleus Development Positive Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Protein Phosphorylation Protein Localization To Endoplasmic Reticulum Regulation Of Phosphorylation Identical Protein Binding TRNA Threonylcarbamoyladenosine Metabolic Process Negative Regulation Of Toll-like Receptor Signaling Pathway TRNA Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Protein Modification Process Regulation Of Toll-like Receptor Signaling Pathway Protein K11-linked Ubiquitination Toll-like Receptor 4 Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Positive Regulation Of Pattern Recognition Receptor Signaling Pathway Intracellular Signaling Cassette Regulation Of Sodium Ion Transport Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Regulation Of Lymphocyte Migration Regulation Of Metal Ion Transport Cell Surface Pattern Recognition Receptor Signaling Pathway Regulation Of TRNA Methylation Golgi To Plasma Membrane Transport Angiotensin-mediated Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Mitotic Cleavage Furrow Formation Positive Regulation Of Nucleocytoplasmic Transport Glucocorticoid Catabolic Process Dentate Gyrus Mossy Fiber Nuclear Inner Membrane Organization Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Steroid Hormone Receptor Signaling Pathway Regulation Of T Cell Activation RNA Stabilization Enzyme Binding Negative Regulation Of RNA Catabolic Process Positive Regulation Of Organelle Assembly Regulation Of Monoatomic Ion Transport Regulation Of Membrane Potential Protein Kinase Binding Response To Heat Cytoplasm Regulation Of Neuron Projection Development Negative Regulation Of Protein Localization To Lysosome Endothelial Cell Migration	Protein Binding Peptide Antigen Assembly With MHC Class II Protein Complex MHC Class II Protein Complex Antigen Processing And Presentation Of Exogenous Peptide Antigen Positive Regulation Of ERAD Pathway Antigen Processing And Presentation Of Exogenous Antigen Regulation Of ERAD Pathway MHC Class II Protein Complex Binding ER To Golgi Transport Vesicle Membrane Lumenal Side Of Endoplasmic Reticulum Membrane Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Peptide Antigen Binding TRC Complex Positive Regulation Of Response To Endoplasmic Reticulum Stress Myeloid Dendritic Cell Antigen Processing And Presentation Transport Vesicle Membrane Antigen Processing And Presentation Trans-Golgi Network Membrane Skeletal Muscle Atrophy Dendritic Cell Antigen Processing And Presentation Positive Regulation Of Proteasomal Protein Catabolic Process Clathrin-coated Endocytic Vesicle Membrane Protein Targeting To ER Regulation Of Protein Ubiquitination Skeletal Muscle Adaptation Striated Muscle Atrophy Lysosomal Membrane Endocytic Vesicle Membrane Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Establishment Of Protein Localization To Endoplasmic Reticulum Autolysosome Membrane Muscle Atrophy Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell MHC Class II Receptor Activity Polyubiquitin Modification-dependent Protein Binding Late Endosome Membrane Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway Regulation Of Post-translational Protein Modification
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