NEK1 and CSN2

Number of citations of the paper that reports this interaction (PubMedID 1382974)
50

Data Source:
HPRD (in vitro)

		NEK1	CSN2
Description		NIMA related kinase 1	casein beta
Image			No pdb structure
GO Annotations	Cellular Component	Pericentriolar Material Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton Cilium Centriolar Satellite	Extracellular Region Extracellular Space
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding 14-3-3 Protein Binding Protein Serine Kinase Activity	Enzyme Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Calcium Ion Binding Protein Binding
	Biological Process	Protein Phosphorylation Cell Projection Organization Cell Division Cilium Assembly	Calcium Ion Transport Lactation
Pathways		Regulation of pyruvate metabolism	Nuclear signaling by ERBB4 Developmental Lineage of Mammary Gland Alveolar Cells
Drugs		Fostamatinib
Diseases		Short rib-polydactyly syndrome
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Daytime nap ( 33568662) Night sleep phenotypes ( 27126917) Schizophrenia ( 25056061 28991256 29483656) Supramarginal gyrus volume ( 31530798)
Interacting Genes		19 interacting genes: ATRX CSN2 CTNNAL1 EXOSC4 FEZ1 FEZ2 KIF3A LRRK1 LRRK2 MFHAS1 MRE11 PPP2R5A PTPRD SIRPA TP53BP1 TSC2 YAP1 YWHAH ZNF350	18 interacting genes: AURKA CDC42 CDK1 CELA1 CSN3 CSNK2A1 CSNK2B FHL2 GRB2 HTRA2 NEK1 NEK2 NEK9 NFYC PLK1 RAC1 TOLLIP UBQLN2
Entrez ID		4750	1447
HPRD ID		06847	00281
Ensembl ID		ENSG00000137601	ENSG00000135222
Uniprot IDs		A0A8I5KUL6 Q96PY6	P05814 W5RWE1
PDB IDs		4APC 4B9D
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cellular Component Organization Negative Regulation Of Macroautophagy Negative Regulation Of Autophagosome Assembly Negative Regulation Of Autophagy Regulation Of Cellular Component Organization Intracellular Signal Transduction Regulation Of Organelle Assembly Regulation Of Autophagosome Assembly Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Metabolic Process Regulation Of Vacuole Organization Negative Regulation Of Cell Projection Organization Glutamatergic Synapse DNA Strand Resection Involved In Replication Fork Processing Regulation Of Macroautophagy Negative Regulation Of Catabolic Process Regulation Of Organelle Organization Cellular Response To Stress Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Neuron Projection Development Regulation Of Cell Projection Organization Positive Regulation Of Signal Transduction Positive Regulation Of Canonical Wnt Signaling Pathway Signal Transduction Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Cellular Component Organization DNA Damage Response Response To Stress Negative Regulation Of Macromolecule Metabolic Process Protein Binding Negative Regulation Of Gene Expression Regulation Of Reactive Oxygen Species Metabolic Process Vesicle Membrane Transcription Factor TFIID Complex Replication Fork Regulation Of Cellular Response To Stress Mitochondrial Double-strand Break Repair Via Homologous Recombination Regulation Of Cell Communication Regulation Of Signal Transduction Regulation Of Postsynapse Organization Regulation Of Signaling Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Cell Communication Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signaling Regulation Of Wnt Signaling Pathway Regulation Of Endocytosis Glucocorticoid Catabolic Process Clathrin Binding Positive Regulation Of Membrane Permeability	Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity Phosphorylation Centrosome Centrosome Separation Protein Kinase Activity Protein Phosphorylation Midbody Regulation Of Attachment Of Spindle Microtubules To Kinetochore Kinase Activity Regulation Of Proteasomal Protein Catabolic Process Protein Localization To Site Of Double-strand Break Spindle Midzone Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Cell Division Protein Kinase Binding Regulation Of Cell Cycle Regulation Of Mitotic Nuclear Division Wnt Signaling Pathway Organelle Organization Positive Regulation Of Organelle Organization Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Mitotic Cell Cycle Spindle Microtubule Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Organelle Organization Mitotic Cell Cycle Regulation Of Nuclear Division Centrosome Cycle Signal Transduction In Response To DNA Damage Nucleotide Binding G2/M Transition Of Mitotic Cell Cycle G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Negative Regulation Of Cell Cycle Cell Cycle G2/M Phase Transition Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Proteolysis Cytoskeleton Organization Ventricular Cardiac Muscle Cell Development Thioesterase Binding Regulation Of Cellular Component Organization Mitotic Nuclear Membrane Disassembly Cytoskeleton Cilium Disassembly Positive Regulation Of Protein Catabolic Process Cytosol Regulation Of Cell Cycle Process
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