RPH3A and GCH1

Number of citations of the paper that reports this interaction (PMID 7802677)
9

Data Source:
HPRD (in vivo)

		RPH3A	GCH1
Gene Name		rabphilin 3A	GTP cyclohydrolase 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Apparatus Cytosol Synaptic Vesicle Extrinsic Component Of Membrane Cell Junction Secretory Granule Synaptic Vesicle Membrane Neuron Projection Protein Complex Synapse	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoplasmic Vesicle Nuclear Membrane Protein Complex
	Molecular Function	Transporter Activity Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Phosphatidylinositol-4,5-bisphosphate Binding Zinc Ion Binding Selenium Binding Rab GTPase Binding Protein Complex Binding Phosphate Ion Binding Inositol 1,4,5 Trisphosphate Binding Phosphatidylinositol Phosphate Binding	GTP Cyclohydrolase I Activity Calcium Ion Binding Protein Binding GTP Binding Zinc Ion Binding GTP-dependent Protein Binding Protein Homodimerization Activity Coenzyme Binding
	Biological Process	Intracellular Protein Transport	Tetrahydrobiopterin Biosynthetic Process Nitric Oxide Biosynthetic Process Metabolic Process Regulation Of Blood Pressure Regulation Of Lung Blood Pressure Response To Lipopolysaccharide Response To Interferon-gamma Response To Tumor Necrosis Factor 7,8-dihydroneopterin 3'-triphosphate Biosynthetic Process Vasodilation Dopamine Biosynthetic Process Pteridine-containing Compound Biosynthetic Process Small Molecule Metabolic Process Negative Regulation Of Blood Pressure Nitric Oxide Metabolic Process Tetrahydrofolate Biosynthetic Process Response To Pain Neuromuscular Process Controlling Posture Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Nitric-oxide Synthase Activity Protein Homooligomerization Protein Heterooligomerization
Pathways			Metabolism of nitric oxide eNOS activation and regulation Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Drugs			Guanine
Diseases
GWAS		Platelet counts ( 22139419)	Obesity-related traits ( 23251661) Rheumatoid arthritis ( 22446963)
Protein-Protein Interactions		10 interactors: ADD2 CASK GCH1 NRXN1 RAB15 RAB27A RAB3A RAB3B RAB8A YWHAH	13 interactors: AHSA1 ATP1B1 CDC37 CNRIP1 GCHFR GIT2 HSPA8 RAB26 RLF RPH3A SH3GL2 SP3 YWHAZ
Entrez ID		22895	2643
HPRD ID		15273	02573
Ensembl ID		ENSG00000089169	ENSG00000131979
Uniprot IDs		Q9Y2J0	P30793 Q8IZH9
PDB IDs			1FB1
Enriched GO Terms of Interacting Partners?		Rab Protein Signal Transduction Vesicle Docking Involved In Exocytosis Vesicle Docking Membrane Docking Protein Secretion Secretion Regulation Of Exocytosis Vesicle Localization Ras Protein Signal Transduction Secretion By Cell Regulation Of Cellular Localization Positive Regulation Of Regulated Secretory Pathway Regulation Of Secretion Neurotransmitter Secretion Regulation Of Synaptic Transmission Synaptic Vesicle Transport Exocytosis Positive Regulation Of Transport Cellular Protein Localization Regulation Of Vesicle-mediated Transport Regulation Of Neurotransmitter Levels Establishment Of Protein Localization Organelle Localization Neurotransmitter Transport Regulation Of Regulated Secretory Pathway Intracellular Protein Transport Establishment Of Vesicle Localization Synaptic Vesicle Exocytosis Positive Regulation Of Exocytosis Synaptic Transmission Protein Localization Small GTPase Mediated Signal Transduction Establishment Of Localization In Cell Establishment Of Organelle Localization Protein Transport Cellular Localization Intracellular Transport Cell-cell Signaling Intracellular Signal Transduction Regulation Of Synaptic Plasticity Regulation Of Ion Transport Transport Vesicle-mediated Transport Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Secretion Membrane Organization Protein Localization To Membrane Maintenance Of Presynaptic Active Zone Structure Positive Regulation Of Constitutive Secretory Pathway Protein Complex Assembly Involved In Synapse Maturation	Intracellular Transport Post-Golgi Vesicle-mediated Transport Establishment Of Localization In Cell Membrane Organization Intracellular Protein Transport Cellular Localization Positive Regulation Of ATPase Activity Regulation Of ATPase Activity Regulated Secretory Pathway Golgi Vesicle Transport Cellular Protein Localization Protein Transport Establishment Of Protein Localization Negative Regulation Of Fibril Organization Negative Regulation Of GTP Cyclohydrolase I Activity Establishment Of Protein Localization To Plasma Membrane Cell-cell Signaling Protein Stabilization Positive Regulation Of Calcium:sodium Antiporter Activity Endomembrane System Organization Positive Regulation Of Potassium Ion Import Regulation Of Fibril Organization Protein Localization Secretion By Cell Golgi Reassembly Positive Regulation Of Sodium Ion Export From Cell Regulation Of Protein Stability Regulation Of Neurotransmitter Levels Regulation Of Metabolic Process Protein Transport Into Plasma Membrane Raft Clathrin Coat Disassembly Protein Localization To Plasma Membrane Protein Localization To Plasma Membrane Raft Histamine Secretion By Mast Cell Sodium Ion Export From Cell Establishment Of Golgi Localization Secretion Positive Regulation Of Metabolic Process Sodium Ion Export Golgi Inheritance Regulation Of Catalytic Activity Cellular Potassium Ion Homeostasis Vesicle-mediated Transport Histamine Secretion Transport Protein Transport Into Membrane Raft Membrane Repolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Plasma Membrane Organization Embryonic Process Involved In Female Pregnancy
Tagcloud ?		abeta25 cholinergic deafferentation downregulated dysfunction exocytosis immunoreactivity interacts involve neocortex neuritic neurofibrillary neuron neurotransmitter plaques postmortem postsynaptic presynaptic rab3a rabphilin reductions selectively snare synaptic synaptopathology tangles triggered vesicle	allele bodily carriers catechol comt confers copies cyclohydrolase disadvantageous enzymatic epistatic esr1 guanosine met methylenetetrahydrofolate minor mthfr musculoskeletal normalized poorer reductase rs10483639 rs3020377 rs4680 temporomandibular thresholds tmd triphosphate val
Tagcloud (Difference) ?		abeta25 cholinergic deafferentation downregulated dysfunction exocytosis immunoreactivity interacts involve neocortex neuritic neurofibrillary neuron neurotransmitter plaques postmortem postsynaptic presynaptic rab3a rabphilin reductions selectively snare synaptic synaptopathology tangles triggered vesicle	allele bodily carriers catechol comt confers copies cyclohydrolase disadvantageous enzymatic epistatic esr1 guanosine met methylenetetrahydrofolate minor mthfr musculoskeletal normalized poorer reductase rs10483639 rs3020377 rs4680 temporomandibular thresholds tmd triphosphate val
Tagcloud (Intersection) ?