RPH3A and RAB3A

Number of citations of the paper that reports this interaction (PMID 10025402)
72

Data Source:
HPRD (in vitro, in vivo)

		RPH3A	RAB3A
Gene Name		rabphilin 3A	RAB3A, member RAS oncogene family
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Apparatus Cytosol Synaptic Vesicle Extrinsic Component Of Membrane Cell Junction Secretory Granule Synaptic Vesicle Membrane Neuron Projection Protein Complex Synapse	Acrosomal Vesicle Endosome Cytosol Plasma Membrane Synaptic Vesicle Axon Secretory Granule Membrane Vesicle Terminal Bouton Protein Complex Clathrin-sculpted Acetylcholine Transport Vesicle Membrane Clathrin-sculpted Glutamate Transport Vesicle Membrane Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Clathrin-sculpted Monoamine Transport Vesicle Membrane
	Molecular Function	Transporter Activity Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Phosphatidylinositol-4,5-bisphosphate Binding Zinc Ion Binding Selenium Binding Rab GTPase Binding Protein Complex Binding Phosphate Ion Binding Inositol 1,4,5 Trisphosphate Binding Phosphatidylinositol Phosphate Binding	ATPase Activator Activity GTPase Activity Protein Binding GTP Binding Protein C-terminus Binding GDP Binding Myosin V Binding GTPase Binding ATPase Binding
	Biological Process	Intracellular Protein Transport	Respiratory System Process Intracellular Protein Transport Vesicle Docking Involved In Exocytosis Mitochondrion Organization Synaptic Transmission Neurotransmitter Secretion Neuromuscular Synaptic Transmission Axonogenesis Protein Secretion Post-embryonic Development Glutamate Secretion Synaptic Vesicle Exocytosis Synaptic Vesicle Maturation Lung Development Regulation Of Synaptic Vesicle Fusion To Presynaptic Membrane Rab Protein Signal Transduction Positive Regulation Of ATPase Activity Synaptic Vesicle Recycling Constitutive Secretory Pathway Positive Regulation Of Exocytosis Regulation Of Short-term Neuronal Synaptic Plasticity Maintenance Of Presynaptic Active Zone Structure Sensory Perception Of Touch Response To Electrical Stimulus Protein Localization To Plasma Membrane Positive Regulation Of Regulated Secretory Pathway
Pathways			Dopamine Neurotransmitter Release Cycle Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Serotonin Neurotransmitter Release Cycle GABA synthesis, release, reuptake and degradation Glutamate Neurotransmitter Release Cycle Transmission across Chemical Synapses
Drugs
Diseases
GWAS		Platelet counts ( 22139419)
Protein-Protein Interactions		10 interactors: ADD2 CASK GCH1 NRXN1 RAB15 RAB27A RAB3A RAB3B RAB8A YWHAH	24 interactors: A2M ADRB2 AP1M2 APP CASK CHM CHML DMXL2 ECSIT EGFR MAST1 PSEN1 RAB3IL1 RAB3IP RABAC1 RABGGTB RABIF RIMS1 RIMS2 RNF32 RPH3A RPH3AL SYTL4 SYTL5
Entrez ID		22895	5864
HPRD ID		15273	01535
Ensembl ID		ENSG00000089169	ENSG00000105649
Uniprot IDs		Q9Y2J0	P20336
PDB IDs
Enriched GO Terms of Interacting Partners?		Rab Protein Signal Transduction Vesicle Docking Involved In Exocytosis Vesicle Docking Membrane Docking Protein Secretion Secretion Regulation Of Exocytosis Vesicle Localization Ras Protein Signal Transduction Secretion By Cell Regulation Of Cellular Localization Positive Regulation Of Regulated Secretory Pathway Regulation Of Secretion Neurotransmitter Secretion Regulation Of Synaptic Transmission Synaptic Vesicle Transport Exocytosis Positive Regulation Of Transport Cellular Protein Localization Regulation Of Vesicle-mediated Transport Regulation Of Neurotransmitter Levels Establishment Of Protein Localization Organelle Localization Neurotransmitter Transport Regulation Of Regulated Secretory Pathway Intracellular Protein Transport Establishment Of Vesicle Localization Synaptic Vesicle Exocytosis Positive Regulation Of Exocytosis Synaptic Transmission Protein Localization Small GTPase Mediated Signal Transduction Establishment Of Localization In Cell Establishment Of Organelle Localization Protein Transport Cellular Localization Intracellular Transport Cell-cell Signaling Intracellular Signal Transduction Regulation Of Synaptic Plasticity Regulation Of Ion Transport Transport Vesicle-mediated Transport Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Secretion Membrane Organization Protein Localization To Membrane Maintenance Of Presynaptic Active Zone Structure Positive Regulation Of Constitutive Secretory Pathway Protein Complex Assembly Involved In Synapse Maturation	Establishment Of Protein Localization Protein Localization Cellular Localization Establishment Of Localization In Cell Protein Transport Intracellular Transport Cellular Protein Localization Exocytosis Intracellular Protein Transport Secretion Secretion By Cell Transport Vesicle-mediated Transport Protein Geranylgeranylation Regulation Of Catalytic Activity Protein Prenylation Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Catalytic Activity Positive Regulation Of Metabolic Process Positive Regulation Of Inhibitory Postsynaptic Membrane Potential Positive Regulation Of Hydrolase Activity Calcium Ion-dependent Exocytosis Of Neurotransmitter Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Regulation Of Inhibitory Postsynaptic Membrane Potential Membrane Organization Neurotransmitter Secretion Regulation Of Signaling Establishment Of Organelle Localization Regulation Of Neurotransmitter Levels Regulation Of Epidermal Growth Factor-activated Receptor Activity Regulation Of Protein Binding Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Exocytosis Positive Regulation Of GTPase Activity Neurological System Process Endoplasmic Reticulum Calcium Ion Homeostasis Neurotransmitter Transport Positive Regulation Of Excitatory Postsynaptic Membrane Potential Organelle Localization Visual Perception Membrane Hyperpolarization Regulation Of GTPase Activity Sensory Perception Of Light Stimulus Vesicle Targeting Positive Regulation Of Membrane Potential Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Establishment Of Vesicle Localization Regulation Of Vasodilation
Tagcloud ?		abeta25 cholinergic deafferentation downregulated dysfunction exocytosis immunoreactivity interacts involve neocortex neuritic neurofibrillary neuron neurotransmitter plaques postmortem postsynaptic presynaptic rab3a rabphilin reductions selectively snare synaptic synaptopathology tangles triggered vesicle	abundant adenohypophyseal anterior att cellubrevin corticotroph endocrine exocytosis fractionation fractions granules immunoblotting immunocytochemical isoform location microvesicles organelles pituitary represented secretory snap subcellular synaptic synaptobrevin synaptophysin synaptotagmin syntaxin took vesicles
Tagcloud (Difference) ?		abeta25 cholinergic deafferentation downregulated dysfunction immunoreactivity interacts involve neocortex neuritic neurofibrillary neuron neurotransmitter plaques postmortem postsynaptic presynaptic rabphilin reductions selectively snare synaptopathology tangles triggered vesicle	abundant adenohypophyseal anterior att cellubrevin corticotroph endocrine fractionation fractions granules immunoblotting immunocytochemical isoform location microvesicles organelles pituitary represented secretory snap subcellular synaptobrevin synaptophysin synaptotagmin syntaxin took vesicles
Tagcloud (Intersection) ?		exocytosis rab3a synaptic