LIN7C and KCNJ12

Number of citations of the paper that reports this interaction (PMID 14960569)
32

Data Source:
HPRD (in vivo, in vitro)

		LIN7C	KCNJ12
Gene Name		lin-7 homolog C (C. elegans)	potassium channel, inwardly rectifying subfamily J, member 12
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Cell-cell Junction Tight Junction Postsynaptic Density Basolateral Plasma Membrane Neuron Projection Synapse Postsynaptic Membrane Extracellular Vesicular Exosome MPP7-DLG1-LIN7 Complex	Plasma Membrane Integral Component Of Plasma Membrane Intrinsic Component Of Membrane
	Molecular Function	Cytoskeletal Protein Binding Protein Domain Specific Binding PDZ Domain Binding L27 Domain Binding	Inward Rectifier Potassium Channel Activity
	Biological Process	Morphogenesis Of An Epithelial Sheet Exocytosis Neurotransmitter Secretion Asymmetric Protein Localization Protein Transport Maintenance Of Epithelial Cell Apical/basal Polarity Protein Localization To Basolateral Plasma Membrane	Potassium Ion Transport Muscle Contraction Synaptic Transmission Regulation Of Heart Contraction Potassium Ion Import Regulation Of Ion Transmembrane Transport Protein Homotetramerization
Pathways			GABA B receptor activation Inwardly rectifying K+ channels GABA receptor activation Activation of G protein gated Potassium channels Classical Kir channels Activation of GABAB receptors Potassium Channels Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell G protein gated Potassium channels Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits Transmission across Chemical Synapses
Drugs			Dofetilide
Diseases
GWAS		Bone mineral density ( 22504420)	Height ( 20881960)
Protein-Protein Interactions		4 interactors: ABCA1 BAIAP2 HTR2C KCNJ12	16 interactors: ABLIM1 APBA1 CASK DLG1 DLG2 DLG3 DLG4 DMD DTNA LIN7A LIN7B LIN7C PRKACA SNTA1 SNTB1 SNTB2
Entrez ID		55327	3768
HPRD ID		17279	09083
Ensembl ID		ENSG00000148943	ENSG00000184185
Uniprot IDs		Q9NUP9	Q14500
PDB IDs		3LRA
Enriched GO Terms of Interacting Partners?		Phospholipase C-activating Serotonin Receptor Signaling Pathway Regulation Of Corticotropin-releasing Hormone Secretion Positive Regulation Of Phosphatidylinositol Biosynthetic Process Interleukin-1 Beta Secretion Phagocytosis Apolipoprotein A-I-mediated Signaling Pathway Positive Regulation Of Phospholipid Biosynthetic Process Interleukin-1 Secretion Negative Regulation Of Cholesterol Storage High-density Lipoprotein Particle Assembly Intracellular Cholesterol Transport Intracellular Sterol Transport Phospholipid Homeostasis Ion Transport Platelet Dense Granule Organization Response To External Stimulus Endomembrane System Organization Cellular Component Assembly Response To Nutrient Levels Phospholipid Efflux Phagocytosis, Engulfment Transport Response To Low-density Lipoprotein Particle Interleukin-1 Beta Production Response To Extracellular Stimulus Response To Bacterium Serotonin Receptor Signaling Pathway Cellular Response To Cholesterol Negative Regulation Of Macrophage Derived Foam Cell Differentiation Response To Drug Reverse Cholesterol Transport Response To Laminar Fluid Shear Stress Membrane Invagination Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Actin Crosslink Formation Protein-lipid Complex Assembly Response To Lipoprotein Particle Cellular Response To Sterol Positive Regulation Of Cholesterol Efflux Negative Regulation Of Lipid Storage Signaling Ion Homeostasis Positive Regulation Of Cholesterol Transport CGMP Biosynthetic Process Cell Communication Synaptic Transmission Regulation Of Appetite Regulation Of Cholesterol Efflux Response To Cholesterol Potassium Ion Import	Establishment Or Maintenance Of Apical/basal Cell Polarity Cell-cell Signaling Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Maintenance Of Apical/basal Cell Polarity Receptor Localization To Synapse Synaptic Transmission Maintenance Of Cell Polarity Nucleotide Phosphorylation Protein Localization To Synapse Establishment Or Maintenance Of Cell Polarity Protein Localization To Membrane Protein Localization To Basolateral Plasma Membrane Maintenance Of Epithelial Cell Apical/basal Polarity Membrane Organization Cellular Protein Localization Receptor Clustering Regulation Of Ion Transmembrane Transport Muscle Contraction Muscle System Process Protein Localization Asymmetric Protein Localization Negative Regulation Of Peptidyl-cysteine S-nitrosylation Regulation Of Ion Transport Regulation Of Sodium Ion Transmembrane Transport Secretion Protein Localization To Plasma Membrane Cellular Localization Endomembrane System Organization Regulation Of Sodium Ion Transport Plasma Membrane Organization Secretion By Cell Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction Movement Of Cell Or Subcellular Component Anatomical Structure Development Nucleotide Metabolic Process Regulation Of Membrane Potential Regulation Of Striated Muscle Contraction Chemotaxis Nervous System Development System Development Nucleobase-containing Small Molecule Metabolic Process Neurotransmitter Secretion Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Exocytosis Developmental Process Signaling Cellular Component Assembly Cell Communication Axon Guidance
Tagcloud ?		adiposity alleles bcdin3d bdnf bmi chinese circumference dgkg etv5 europeans faim2 former fto gnpda2 hong kctd15 kong loci lost mc4r modestly mtch2 negr1 obesity sec16b sh2b1 t2d tmem18 waist
Tagcloud (Difference) ?		adiposity alleles bcdin3d bdnf bmi chinese circumference dgkg etv5 europeans faim2 former fto gnpda2 hong kctd15 kong loci lost mc4r modestly mtch2 negr1 obesity sec16b sh2b1 t2d tmem18 waist
Tagcloud (Intersection) ?