LIN7C and MPP2

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology)

		LIN7C	MPP2
Description		lin-7 cell polarity scaffold C	MAGUK p55 scaffold protein 2
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Basolateral Plasma Membrane Synapse Postsynaptic Membrane Anchoring Junction MPP7-DLG1-LIN7 Complex Presynapse Postsynaptic Density Membrane Glutamatergic Synapse	Cytoplasm Cytoskeleton Plasma Membrane Cell-cell Junction Postsynaptic Density Membrane Dendrite Dendrite Membrane Cell Projection Dendritic Spine Dendritic Shaft Organelle Synapse
	Molecular Function	Protein Binding Cytoskeletal Protein Binding Protein Domain Specific Binding PDZ Domain Binding Protein-macromolecule Adaptor Activity L27 Domain Binding	Protein Binding
	Biological Process	Morphogenesis Of An Epithelial Sheet Exocytosis Neurotransmitter Secretion Regulation Of Synaptic Assembly At Neuromuscular Junction Protein Transport Synaptic Vesicle Transport	Protein Homooligomerization Excitatory Postsynaptic Potential Long-term Synaptic Potentiation
Pathways		Dopamine Neurotransmitter Release Cycle Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors
Drugs
Diseases
GWAS		Bone mineral density (paediatric, skull) ( 24945404) Brain morphology (MOSTest) ( 32665545) Chronotype ( 30696823) Feeling miserable ( 29500382) Feeling nervous ( 29500382) Hip circumference ( 25673412) Lumbar spine bone mineral density ( 22504420) Menarche (age at onset) ( 27182965) Morning person ( 30696823) Survival in pancreatic cancer ( 28470677)	Cognitive function ( 24684796)
Interacting Genes		9 interacting genes: ABCA1 BAIAP2 DNAJC5 HTR2C KCNJ12 MPP2 MPP7 SNCA YES1	6 interacting genes: CSNK2B DLG1 ERBIN LIN7A LIN7C PLK1
Entrez ID		55327	4355
HPRD ID		17279	02837
Ensembl ID		ENSG00000148943	ENSG00000108852
Uniprot IDs		Q9NUP9	A0A0A0MRU0 A0A0C4DH75 B4DRL7 B4DZ84 D3DX48 D3DX49 Q14168
PDB IDs		3LRA	2E7K
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein-containing Complex Assembly Plasma Membrane Regulation Of Transport Regulation Of Protein-containing Complex Assembly Signal Release Positive Regulation Of Cellular Component Biogenesis Regulation Of Synaptic Plasticity Synaptic Vesicle Exocytosis Cellular Response To Retinoic Acid Cellular Component Assembly Sphingolipid Floppase Activity Membrane Protein Complex Oligomerization Long-term Synaptic Potentiation Excitatory Postsynaptic Potential Dendritic Shaft Response To Desipramine Presynapse Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Response To Growth Factor Cellular Response To Growth Factor Stimulus Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Dendritic Spine Cytoplasm Neuron Projection Branch Point Regulation Of Biological Quality Response To Vitamin B3 Secretion By Cell Positive Regulation Of High-density Lipoprotein Particle Assembly Apolipoprotein A-I Receptor Activity 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine Binding Protein Tetramerization Vesicle-mediated Transport In Synapse Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Protein Localization To Cell Junction Response To Retinoic Acid Regulation Of Multicellular Organismal Process Regulation Of High-density Lipoprotein Particle Assembly Gq/11-coupled Serotonin Receptor Activity Positive Regulation Of Phosphatidylinositol Biosynthetic Process Regulation Of Postsynaptic Membrane Potential Regulation Of Membrane Potential Negative Regulation Of Serotonin Uptake Neuron Apoptotic Process Transporter Regulator Activity Regulated Exocytosis Negative Regulation Of Chaperone-mediated Autophagy	L27 Domain Binding MPP7-DLG1-LIN7 Complex Basolateral Plasma Membrane Establishment Of Organelle Localization Anchoring Junction Postsynaptic Density Membrane Regulation Of Synaptic Assembly At Neuromuscular Junction Bicellular Tight Junction Organelle Localization Cell-cell Junction Protein-macromolecule Adaptor Activity Intracellular Protein Localization Synaptic Vesicle Transport Neurotransmitter Secretion Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Morphogenesis Of An Epithelium Establishment Or Maintenance Of Apical/basal Cell Polarity Tissue Morphogenesis Cytoskeletal Protein Binding Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Neuromuscular Junction Establishment Of Protein Localization Basement Membrane Neurotransmitter Transport Establishment Of Vesicle Localization Glutamatergic Synapse Synaptonemal Complex Disassembly Golgi Inheritance Basal Protein Localization Vesicle Localization Establishment Of Localization In Cell Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Structural Constituent Of Postsynaptic Density ErbB-2 Class Receptor Binding Regulation Of Protein Localization To Cell Periphery Negative Regulation Of Mitotic Cell Cycle Phase Transition Lateral Loop Spindle Organization Establishment Or Maintenance Of Cell Polarity Signal Release Regulation Of Synapse Assembly Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Regulation Of Ubiquitin-dependent Protein Catabolic Process Release From Viral Latency Maintenance Of Postsynaptic Density Structure Myelin Sheath Abaxonal Region Homologous Chromosome Segregation Female Meiosis Chromosome Segregation
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