LIN7C and BAIAP2

Number of citations of the paper that reports this interaction (PubMedID 14596909)
0

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		LIN7C	BAIAP2
Description		lin-7 cell polarity scaffold C	BAR/IMD domain containing adaptor protein 2
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Cell-cell Junction Bicellular Tight Junction Membrane Basolateral Plasma Membrane Synapse Postsynaptic Membrane Anchoring Junction MPP7-DLG1-LIN7 Complex Presynapse Postsynaptic Density Membrane Glutamatergic Synapse	Ruffle Nucleoplasm Cytoplasm Cytosol Cytoskeleton Microtubule Plasma Membrane Adherens Junction Postsynaptic Density Actin Cytoskeleton Membrane Lamellipodium Secretory Granule Filopodium Cell Projection Neuron Projection Neuronal Cell Body Dendritic Spine Dendritic Shaft Neuron Projection Terminus Excitatory Synapse Neuron Projection Branch Point Dendritic Spine Cytoplasm Extracellular Exosome Synaptic Membrane Schaffer Collateral - CA1 Synapse Presynapse Postsynapse Glutamatergic Synapse Postsynaptic Density, Intracellular Component Presynaptic Cytosol Postsynaptic Cytosol
	Molecular Function	Protein Binding Cytoskeletal Protein Binding Protein Domain Specific Binding PDZ Domain Binding Protein-macromolecule Adaptor Activity L27 Domain Binding	Transcription Coregulator Binding Protein Binding Cytoskeletal Anchor Activity PDZ Domain Binding Identical Protein Binding Proline-rich Region Binding Scaffold Protein Binding Cadherin Binding Involved In Cell-cell Adhesion
	Biological Process	Morphogenesis Of An Epithelial Sheet Exocytosis Neurotransmitter Secretion Regulation Of Synaptic Assembly At Neuromuscular Junction Protein Transport Synaptic Vesicle Transport	Plasma Membrane Organization Axonogenesis Insulin Receptor Signaling Pathway Regulation Of Cell Shape Positive Regulation Of Neuron Projection Development Dendrite Development Neuron Differentiation Positive Regulation Of Actin Filament Polymerization Regulation Of Actin Cytoskeleton Organization Protein Localization To Synapse Regulation Of Synaptic Plasticity Modulation Of Chemical Synaptic Transmission Actin Filament Bundle Assembly Actin Crosslink Formation Positive Regulation Of Dendritic Spine Morphogenesis Cellular Response To Epidermal Growth Factor Stimulus Cell-cell Adhesion Regulation Of Postsynapse Organization Cellular Response To L-glutamate Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Positive Regulation Of Excitatory Postsynaptic Potential
Pathways		Dopamine Neurotransmitter Release Cycle Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs CDC42 GTPase cycle RAC1 GTPase cycle RAC3 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Bone mineral density (paediatric, skull) ( 24945404) Brain morphology (MOSTest) ( 32665545) Chronotype ( 30696823) Feeling miserable ( 29500382) Feeling nervous ( 29500382) Hip circumference ( 25673412) Lumbar spine bone mineral density ( 22504420) Menarche (age at onset) ( 27182965) Morning person ( 30696823) Survival in pancreatic cancer ( 28470677)	Adult body size ( 32376654) Adverse response to drug ( 30420678) Beef consumption ( 32066663) Body size at age 10 ( 32376654) Breast cancer ( 29871690) Daytime nap ( 33568662) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Feeling tense ( 29500382) General factor of neuroticism ( 30867560) Memory performance ( 24392092) Neurociticism ( 29500382) Neuroticism ( 29255261) Serum uric acid levels in response to allopurinol in gout ( 25676789)
Interacting Genes		9 interacting genes: ABCA1 BAIAP2 DNAJC5 HTR2C KCNJ12 MPP2 MPP7 SNCA YES1	42 interacting genes: ADGRB1 APP ATN1 C19orf25 CDC42 COG6 DAPK1 DIAPH1 EGFR ENAH EPS8 ERG28 ESPN GRB10 HOXD8 KANK1 KDM1A LIN7A LIN7B LIN7C MARK2 NCKIPSD NEDD4 NRIP1 OGT PAK1 PBX2 PKNOX1 PRR13 RAC1 RTN4 SF3A2 SF3B4 SHANK1 SHANK2 SHANK3 SRPK2 TBX5 TP53BP2 UBC WASF2 YWHAG
Entrez ID		55327	10458
HPRD ID		17279	05686
Ensembl ID		ENSG00000148943	ENSG00000175866
Uniprot IDs		Q9NUP9	I3L4C2 Q9UQB8
PDB IDs		3LRA	1WDZ 1Y2O 2YKT 3RNJ 4JS0 6BCR 6BCY 6BD1 6BD2 6BQT 6ZEG 6ZEI
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein-containing Complex Assembly Plasma Membrane Regulation Of Transport Regulation Of Protein-containing Complex Assembly Signal Release Positive Regulation Of Cellular Component Biogenesis Regulation Of Synaptic Plasticity Synaptic Vesicle Exocytosis Cellular Response To Retinoic Acid Cellular Component Assembly Sphingolipid Floppase Activity Membrane Protein Complex Oligomerization Long-term Synaptic Potentiation Excitatory Postsynaptic Potential Dendritic Shaft Response To Desipramine Presynapse Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Response To Growth Factor Cellular Response To Growth Factor Stimulus Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Dendritic Spine Cytoplasm Neuron Projection Branch Point Regulation Of Biological Quality Response To Vitamin B3 Secretion By Cell Positive Regulation Of High-density Lipoprotein Particle Assembly Apolipoprotein A-I Receptor Activity 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine Binding Protein Tetramerization Vesicle-mediated Transport In Synapse Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Protein Localization To Cell Junction Response To Retinoic Acid Regulation Of Multicellular Organismal Process Regulation Of High-density Lipoprotein Particle Assembly Gq/11-coupled Serotonin Receptor Activity Positive Regulation Of Phosphatidylinositol Biosynthetic Process Regulation Of Postsynaptic Membrane Potential Regulation Of Membrane Potential Negative Regulation Of Serotonin Uptake Neuron Apoptotic Process Transporter Regulator Activity Regulated Exocytosis Negative Regulation Of Chaperone-mediated Autophagy	Regulation Of Synapse Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Synapse Assembly SH3 Domain Binding Regulation Of Cell Projection Organization Regulation Of Cell Junction Assembly Regulation Of Cellular Component Organization Synapse Cell Projection Synaptic Receptor Adaptor Activity MPP7-DLG1-LIN7 Complex Ruffle Membrane Positive Regulation Of Cell Projection Organization Regulation Of Developmental Process Regulation Of Actin Filament Organization Regulation Of Supramolecular Fiber Organization Cell Projection Morphogenesis Regulation Of Cytoskeleton Organization Cell-cell Junction Glutamatergic Synapse Cell Motility Regulation Of Neuron Projection Development Ionotropic Glutamate Receptor Binding Cell Migration Regulation Of Postsynapse Organization Postsynaptic Membrane Regulation Of Actin Cytoskeleton Organization Regulation Of Synaptic Assembly At Neuromuscular Junction Positive Regulation Of Cellular Component Organization Neuron Projection Development Intracellular Signal Transduction Postsynaptic Density Neuron Projection Morphogenesis Regulation Of Actin Filament-based Process Neuron Projection Organization Postsynapse Organization Anatomical Structure Morphogenesis Anchoring Junction Plasma Membrane Negative Regulation Of Cellular Component Organization Regulation Of Lamellipodium Organization Cell Projection Organization Regulation Of Synaptic Plasticity Regulation Of Developmental Growth Dendritic Spine Morphogenesis Positive Regulation Of Cell Communication Regulation Of Growth Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein-containing Complex Protein Localization To Lysosome
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