GP6 and FCGR2A

Number of citations of the paper that reports this interaction (PubMedID 9280292)
0

Data Source:
HPRD (in vivo)

		GP6	FCGR2A
Description		glycoprotein VI platelet	Fc gamma receptor IIa
Image
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Membrane Raft Extracellular Exosome Tetraspanin-enriched Microdomain	Plasma Membrane External Side Of Plasma Membrane Membrane Secretory Granule Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Collagen Binding Signaling Receptor Activity Collagen Receptor Activity Protein Tyrosine Kinase Binding	Protein Binding IgG Receptor Activity IgG Binding
	Biological Process	Immune Response-regulating Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Blood Coagulation Hemostasis Platelet Activation Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Collagen-activated Signaling Pathway Platelet Aggregation Positive Regulation Of Platelet Aggregation	Antibody-dependent Cellular Cytotoxicity Immune System Process Cell Surface Receptor Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Production Fc-gamma Receptor Signaling Pathway Positive Regulation Of Phagocytosis
Pathways		GPVI-mediated activation cascade Cell surface interactions at the vascular wall Platelet Adhesion to exposed collagen	FCGR activation FCGR activation Regulation of actin dynamics for phagocytic cup formation Role of phospholipids in phagocytosis Neutrophil degranulation FCGR3A-mediated IL10 synthesis
Drugs			Cetuximab Etanercept Human immunoglobulin G Abciximab Alemtuzumab Daclizumab Bevacizumab Catumaxomab Sarilumab
Diseases			Systemic lupus erythematosus
GWAS		Blood protein levels ( 30072576) Breast cancer and/or colorectal cancer ( 29698419) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Inflammatory biomarkers (multivariate analysis) ( 33110245) Mean platelet volume ( 27863252 32888494) Mean spheric corpuscular volume ( 32888494) Platelet aggregation ( 29185836 20526338) Platelet count ( 32888494) Platelet distribution width ( 27863252 32888494) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Venous thromboembolism ( 31420334)	Ankylosing spondylitis ( 23749187) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Blood protein levels ( 30072576) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Functional impairment in major depressive disorder, bipolar disorder and schizophrenia ( 24039173) Helicobacter pylori serologic status ( 23652523) Hematocrit ( 27863252) Hemoglobin levels ( 32327693) Inflammatory bowel disease ( 28067908 23128233) Kawasaki disease ( 33772158 28886140 22081228) Lipid metabolism phenotypes ( 22286219) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Rheumatoid arthritis ( 30423114 24390342) Rheumatoid arthritis (ACPA-positive) ( 24532676) Systemic lupus erythematosus ( 26663301 28714469 27399966 26502338 24871463) Takayasu arteritis ( 23830517) Ulcerative colitis ( 28067908 19915573 21297633 20228799)
Interacting Genes		7 interacting genes: CRP FCER1G FCGR2A FCGR3A FYN LYN YES1	26 interacting genes: ADAM33 AGPAT4 BLK CDIPT CMTM5 CRP CRYAB CSGALNACT2 CXCL9 FXYD3 FYN GIMAP1 GP6 GRB2 HCK LAT LGALS3 LYN MIP NSG1 PIK3R1 SERP2 SHC1 SYK UBQLN1 UPK2
Entrez ID		51206	2212
HPRD ID		10406	00906
Ensembl ID		ENSG00000088053	ENSG00000143226
Uniprot IDs		Q9HCN6	A0A8V8TPS4 P12318
PDB IDs		2GI7 5OU7 5OU8 5OU9 7NMU 7R58	1FCG 1H9V 3D5O 3RY4 3RY5 3RY6 8CHA
Enriched GO Terms of Interacting Partners?		Fc-gamma Receptor Signaling Pathway Fc Receptor Signaling Pathway Immune Effector Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Immune Response-regulating Signaling Pathway IgG Binding Adaptive Immune Response Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Immune System Process Regulation Of Immune Response Negative Regulation Of Inflammatory Response To Antigenic Stimulus Immunoglobulin Mediated Immune Response Fc-gamma Receptor III Complex Non-membrane Spanning Protein Tyrosine Kinase Activity B Cell Mediated Immunity T Cell Costimulation Immune Response Ephrin Receptor Signaling Pathway Leukocyte Migration Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Cell Activation Acute Inflammatory Response IgG Receptor Activity Regulation Of Immune System Process Antibody-dependent Cellular Cytotoxicity Regulation Of Multicellular Organismal Process Regulation Of Cytokine Production Positive Regulation Of Lymphocyte Activation Positive Regulation Of Multicellular Organismal Process Immune Response-activating Signaling Pathway Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulated Exocytosis Hypersensitivity Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Cell Activation Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Regulation Of Inflammatory Response Lymphocyte Mediated Immunity Activation Of Immune Response Positive Regulation Of Immune System Process Protein Tyrosine Kinase Activity Cell Surface Receptor Signaling Pathway Lymphocyte Activation Acute Inflammatory Response To Antigenic Stimulus Transmembrane Transporter Binding Leukocyte Mediated Immunity Regulation Of Lymphocyte Activation Negative Regulation Of Immune System Process Stimulatory C-type Lectin Receptor Signaling Pathway	Fc Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Effector Process Immune Response-regulating Signaling Pathway Leukocyte Degranulation Regulation Of Immune Response Fc Receptor Mediated Stimulatory Signaling Pathway Regulated Exocytosis Negative Regulation Of Inflammatory Response To Antigenic Stimulus Leukocyte Migration Non-membrane Spanning Protein Tyrosine Kinase Activity Lymphocyte Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Phosphotyrosine Residue Binding Peptidyl-tyrosine Phosphorylation Immune Response Cell Activation IgE Binding Negative Regulation Of Immune System Process Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Adaptive Immune Response Lymphocyte Mediated Immunity Fc-epsilon Receptor Signaling Pathway Neurotrophin TRKA Receptor Binding Leukocyte Activation Mast Cell Degranulation Exocytosis Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Immune System Process Membrane Defense Response Negative Regulation Of Immune Response Ephrin Receptor Binding Regulation Of Reactive Oxygen Species Metabolic Process Leukocyte Mediated Immunity Immune Response-activating Signaling Pathway Regulation Of Cell Activation Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune System Process Response To Stress Hypersensitivity Immunoglobulin Mediated Immune Response Secretion By Cell Response To Other Organism Regulation Of Transport Activation Of Immune Response IgG Binding Defense Response To Symbiont B Cell Mediated Immunity
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