GP6 and FCGR2A

Number of citations of the paper that reports this interaction (PMID 9295288)
36

Data Source:
HPRD (in vivo)

		GP6	FCGR2A
Gene Name		glycoprotein VI (platelet)	Fc fragment of IgG, low affinity IIa, receptor (CD32)
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Extracellular Vesicular Exosome Tetraspanin-enriched Microdomain	Plasma Membrane Integral Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	Receptor Activity Transmembrane Signaling Receptor Activity Protein Binding Collagen Binding	IgG Binding
	Biological Process	Enzyme Linked Receptor Protein Signaling Pathway Blood Coagulation Platelet Activation Leukocyte Migration	Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response
Pathways		Platelet Adhesion to exposed collagen GPVI-mediated activation cascade Platelet activation, signaling and aggregation Cell surface interactions at the vascular wall	Role of phospholipids in phagocytosis Fcgamma receptor (FCGR) dependent phagocytosis FCGR activation Regulation of actin dynamics for phagocytic cup formation Innate Immune System
Drugs
Diseases
GWAS		Platelet aggregation ( 20526338)	Helicobacter pylori serologic status ( 23652523) Inflammatory bowel disease ( 23128233) Kawasaki disease ( 22081228) Lipid metabolism phenotypes ( 22286219) Ulcerative colitis ( 19915573 20228799 21297633)
Protein-Protein Interactions		7 interactors: CRP FCER1G FCGR2A FCGR3A FYN LYN YES1	13 interactors: BLK CRP CRYAB FYN GP6 HCK LAT LGALS3 LYN PIK3R1 SHC1 SYK UBQLN1
Entrez ID		51206	2212
HPRD ID		10406	00906
Ensembl ID		ENSG00000088053	ENSG00000143226
Uniprot IDs		Q9HCN6	P12318
PDB IDs		2GI7	1FCG 1H9V 3D5O 3RY4 3RY5 3RY6
Enriched GO Terms of Interacting Partners?		Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of Immune Response Endocytosis Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Immune System Process Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Immune Response Regulation Of Immune System Process Defense Response Vesicle-mediated Transport Innate Immune Response Immune System Process Peptidyl-tyrosine Autophosphorylation Wound Healing Leukocyte Migration Response To Wounding Positive Regulation Of Cell Activation T Cell Costimulation Response To Stress Ephrin Receptor Signaling Pathway Blood Coagulation Hemostasis Cellular Response To Platelet-derived Growth Factor Stimulus Response To Platelet-derived Growth Factor Regulation Of Cell Activation Regulation Of Body Fluid Levels Chemotaxis Platelet Activation Transport Protein Autophosphorylation Positive Regulation Of T Cell Activation Regulation Of Mast Cell Degranulation Positive Regulation Of Neuron Projection Development Production Of Molecular Mediator Involved In Inflammatory Response Positive Regulation Of Homotypic Cell-cell Adhesion Fc-epsilon Receptor Signaling Pathway Regulation Of Platelet Activation Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell-cell Adhesion Mast Cell Activation Regulation Of Mast Cell Activation Leukocyte Mediated Immunity Cell Migration Response To External Stimulus	Leukocyte Migration Regulation Of Immune Response Platelet Activation Immune Response-regulating Cell Surface Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Response To Stress Immune Response-regulating Signaling Pathway Fc Receptor Signaling Pathway Innate Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Immune Response Regulation Of Immune System Process Defense Response Positive Regulation Of Immune System Process Wound Healing Immune System Process Positive Regulation Of Immune Response Cell Activation Response To Wounding Blood Coagulation Hemostasis Fc-epsilon Receptor Signaling Pathway Cell Migration Phagocytosis Peptidyl-tyrosine Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Cell Motility Regulation Of T Cell Activation Cellular Response To Peptide Hormone Stimulus Regulation Of Body Fluid Levels Cellular Response To Peptide Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Protein Autophosphorylation Locomotion Response To Peptide Hormone Cellular Response To Stimulus Cellular Response To Organonitrogen Compound Regulation Of Cell Activation Leukocyte Activation Response To Peptide Response To Hormone Movement Of Cell Or Subcellular Component Transcription Factor Import Into Nucleus Cellular Response To Hormone Stimulus
Tagcloud ?		acetyl antiviral arrested assayed baculovirus classical csfv designated excluded fever flavivirus galactopyranosyl glucopyranosyl glycoproteins glycosylation insect investigating nitro pyridyl rns round sk6 steps sulfoxide swine tetra thio tri unrelated	arm arms benefit carriers concurrently deriving dfs equivocal fcgammar genotypes genotypic genotyping i232t igg1 killer log n9831 polymorphisms pooled portion proportional r131h rank sequentially superior trastuzumab v158f
Tagcloud (Difference) ?		acetyl antiviral arrested assayed baculovirus classical csfv designated excluded fever flavivirus galactopyranosyl glucopyranosyl glycoproteins glycosylation insect investigating nitro pyridyl rns round sk6 steps sulfoxide swine tetra thio tri unrelated	arm arms benefit carriers concurrently deriving dfs equivocal fcgammar genotypes genotypic genotyping i232t igg1 killer log n9831 polymorphisms pooled portion proportional r131h rank sequentially superior trastuzumab v158f
Tagcloud (Intersection) ?