GP6

Description		glycoprotein VI platelet
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GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Membrane Raft Extracellular Exosome Tetraspanin-enriched Microdomain
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Collagen Binding Signaling Receptor Activity Collagen Receptor Activity Protein Tyrosine Kinase Binding
	Biological Process	Immune Response-regulating Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Blood Coagulation Hemostasis Platelet Activation Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Collagen-activated Signaling Pathway Platelet Aggregation Positive Regulation Of Platelet Aggregation
Pathways		GPVI-mediated activation cascade Cell surface interactions at the vascular wall Platelet Adhesion to exposed collagen
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Breast cancer and/or colorectal cancer ( 29698419) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Inflammatory biomarkers (multivariate analysis) ( 33110245) Mean platelet volume ( 27863252 32888494) Mean spheric corpuscular volume ( 32888494) Platelet aggregation ( 29185836 20526338) Platelet count ( 32888494) Platelet distribution width ( 27863252 32888494) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Venous thromboembolism ( 31420334)
Interacting Genes		7 interacting genes: CRP FCER1G FCGR2A FCGR3A FYN LYN YES1
Entrez ID		51206
HPRD ID		10406
Ensembl ID		ENSG00000088053
Uniprot IDs		Q9HCN6
PDB IDs		2GI7 5OU7 5OU8 5OU9 7NMU 7R58
Enriched GO Terms of Interacting Partners?		Fc-gamma Receptor Signaling Pathway Fc Receptor Signaling Pathway Immune Effector Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Immune Response-regulating Signaling Pathway IgG Binding Adaptive Immune Response Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Immune System Process Regulation Of Immune Response Negative Regulation Of Inflammatory Response To Antigenic Stimulus Immunoglobulin Mediated Immune Response Fc-gamma Receptor III Complex Non-membrane Spanning Protein Tyrosine Kinase Activity B Cell Mediated Immunity T Cell Costimulation Immune Response Ephrin Receptor Signaling Pathway Leukocyte Migration Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Cell Activation Acute Inflammatory Response IgG Receptor Activity Regulation Of Immune System Process Antibody-dependent Cellular Cytotoxicity Regulation Of Multicellular Organismal Process Regulation Of Cytokine Production Positive Regulation Of Lymphocyte Activation Positive Regulation Of Multicellular Organismal Process Immune Response-activating Signaling Pathway Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulated Exocytosis Hypersensitivity Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Cell Activation Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Regulation Of Inflammatory Response Lymphocyte Mediated Immunity Activation Of Immune Response Positive Regulation Of Immune System Process Protein Tyrosine Kinase Activity Cell Surface Receptor Signaling Pathway Lymphocyte Activation Acute Inflammatory Response To Antigenic Stimulus Transmembrane Transporter Binding Leukocyte Mediated Immunity Regulation Of Lymphocyte Activation Negative Regulation Of Immune System Process Stimulatory C-type Lectin Receptor Signaling Pathway
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