GP6 and CRP

Number of citations of the paper that reports this interaction (PubMedID 11027634)
0

Data Source:
HPRD (in vitro)

		GP6	CRP
Description		glycoprotein VI platelet	C-reactive protein
Image
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Membrane Raft Extracellular Exosome Tetraspanin-enriched Microdomain	Extracellular Region Extracellular Space
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Collagen Binding Signaling Receptor Activity Collagen Receptor Activity Protein Tyrosine Kinase Binding	Complement Component C1q Complex Binding Calcium Ion Binding Protein Binding Low-density Lipoprotein Particle Binding Choline Binding Identical Protein Binding Virion Binding Metal Ion Binding Low-density Lipoprotein Particle Receptor Binding
	Biological Process	Immune Response-regulating Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Blood Coagulation Hemostasis Platelet Activation Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Collagen-activated Signaling Pathway Platelet Aggregation Positive Regulation Of Platelet Aggregation	Acute-phase Response Inflammatory Response Opsonization Positive Regulation Of Gene Expression Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Lipid Storage Regulation Of Interleukin-8 Production Positive Regulation Of Superoxide Anion Generation Negative Regulation Of Mononuclear Cell Proliferation Vasoconstriction Innate Immune Response Defense Response To Gram-positive Bacterium
Pathways		GPVI-mediated activation cascade Cell surface interactions at the vascular wall Platelet Adhesion to exposed collagen	Classical antibody-mediated complement activation
Drugs			N,N,N-Trimethyl-2-(phosphonooxy)ethanaminium CRx-139
Diseases			Systemic lupus erythematosus
GWAS		Blood protein levels ( 30072576) Breast cancer and/or colorectal cancer ( 29698419) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Inflammatory biomarkers (multivariate analysis) ( 33110245) Mean platelet volume ( 27863252 32888494) Mean spheric corpuscular volume ( 32888494) Platelet aggregation ( 29185836 20526338) Platelet count ( 32888494) Platelet distribution width ( 27863252 32888494) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Venous thromboembolism ( 31420334)	Blood protein levels ( 30072576 23696881) C-reactive protein ( 18439548 18439552 23844046 19567438 21196492 21647738 22492993 22939635) C-reactive protein levels ( 28548082 24763700 29403010 29878111 30388399 33227023 33339817 21300955) C-reactive protein levels in ischemic stroke ( 26718567) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Erythropoietin levels ( 33227023) High-sensitivity C-reactive protein levels in HIV infection ( 33095540) Inflammatory biomarkers ( 22291609) Inflammatory biomarkers in Kawasaki disease ( 25266886) Lung cancer ( 18385676) Metabolic traits ( 19060910) Protein quantitative trait loci ( 18464913) Select biomarker traits ( 17903293) Serum C-reactive protein concentration ( 32928877) Serum C-reactive protein concentration in obesity ( 32928877) Serum C-reactive protein concentration in visceral obesity (waist circumference) ( 32928877)
Interacting Genes		7 interacting genes: CRP FCER1G FCGR2A FCGR3A FYN LYN YES1	22 interacting genes: APCS C1QA CFH ESS2 FCGR1A FCGR2A FCGR2B FN1 GLUD1 GMPPA GP6 H1-1 H2AC16 H2AC20 LAMC3 LEP MAPK1 MAPK3 MAPK8IP2 RPL13A SNRNP70 UBE3A
Entrez ID		51206	1401
HPRD ID		10406	00422
Ensembl ID		ENSG00000088053	ENSG00000132693
Uniprot IDs		Q9HCN6	P02741 Q5VVP7
PDB IDs		2GI7 5OU7 5OU8 5OU9 7NMU 7R58	1B09 1GNH 1LJ7 3L2Y 3PVN 3PVO 7PK9 7PKB 7PKD 7PKE 7PKF 7PKG 7PKH 7TBA 8WV4 8WV5
Enriched GO Terms of Interacting Partners?		Fc-gamma Receptor Signaling Pathway Fc Receptor Signaling Pathway Immune Effector Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Immune Response-regulating Signaling Pathway IgG Binding Adaptive Immune Response Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Immune System Process Regulation Of Immune Response Negative Regulation Of Inflammatory Response To Antigenic Stimulus Immunoglobulin Mediated Immune Response Fc-gamma Receptor III Complex Non-membrane Spanning Protein Tyrosine Kinase Activity B Cell Mediated Immunity T Cell Costimulation Immune Response Ephrin Receptor Signaling Pathway Leukocyte Migration Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Cell Activation Acute Inflammatory Response IgG Receptor Activity Regulation Of Immune System Process Antibody-dependent Cellular Cytotoxicity Regulation Of Multicellular Organismal Process Regulation Of Cytokine Production Positive Regulation Of Lymphocyte Activation Positive Regulation Of Multicellular Organismal Process Immune Response-activating Signaling Pathway Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulated Exocytosis Hypersensitivity Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Cell Activation Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Regulation Of Inflammatory Response Lymphocyte Mediated Immunity Activation Of Immune Response Positive Regulation Of Immune System Process Protein Tyrosine Kinase Activity Cell Surface Receptor Signaling Pathway Lymphocyte Activation Acute Inflammatory Response To Antigenic Stimulus Transmembrane Transporter Binding Leukocyte Mediated Immunity Regulation Of Lymphocyte Activation Negative Regulation Of Immune System Process Stimulatory C-type Lectin Receptor Signaling Pathway	IgG Binding Acute Inflammatory Response IgG Receptor Activity Regulation Of Immune System Process Antibody-dependent Cellular Cytotoxicity Hypersensitivity Acute Inflammatory Response To Antigenic Stimulus Regulation Of Immune Response Interleukin-34-mediated Signaling Pathway Lung Morphogenesis Fc-gamma Receptor Signaling Pathway Endocytosis Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Positive Regulation Of Tumor Necrosis Factor Production Inflammatory Response To Antigenic Stimulus Regulation Of Stress-activated MAPK Cascade Caveolin-mediated Endocytosis Regulation Of Golgi Inheritance Positive Regulation Of Macrophage Proliferation Regulation Of Stress-activated Protein Kinase Signaling Cascade Immunoglobulin Mediated Immune Response Positive Regulation Of Immune System Process Regulation Of Leukocyte Proliferation Regulation Of Acute Inflammatory Response B Cell Mediated Immunity Cardiac Neural Crest Cell Development Involved In Heart Development Trachea Formation Positive Regulation Of Endocytosis Fc Receptor Signaling Pathway Regulation Of Vesicle-mediated Transport Regulation Of Defense Response Outer Ear Morphogenesis ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Positive Regulation Of Leukocyte Proliferation Regulation Of Tumor Necrosis Factor Production Bergmann Glial Cell Differentiation Glial Cell Development Import Into Cell Negative Regulation Of Acute Inflammatory Response Regulation Of Lymphocyte Mediated Immunity Immune Effector Process Positive Regulation Of Phagocytosis Leukocyte Mediated Cytotoxicity Regulation Of Cell Activation Response To External Biotic Stimulus Regulation Of MAPK Cascade Regulation Of Natural Killer Cell Proliferation Immune Response-regulating Signaling Pathway Regulation Of Inflammatory Response
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