GP6 and CRP

Number of citations of the paper that reports this interaction (PMID 11027634)
6

Data Source:
HPRD (in vitro)

		GP6	CRP
Gene Name		glycoprotein VI (platelet)	C-reactive protein, pentraxin-related
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Extracellular Vesicular Exosome Tetraspanin-enriched Microdomain	Extracellular Region Extracellular Space Filopodium Growth Cone Extracellular Vesicular Exosome
	Molecular Function	Receptor Activity Transmembrane Signaling Receptor Activity Protein Binding Collagen Binding	Complement Component C1q Binding Calcium Ion Binding Protein Binding Cholesterol Binding Low-density Lipoprotein Particle Binding Choline Binding Protein Homodimerization Activity Virion Binding Low-density Lipoprotein Particle Receptor Binding
	Biological Process	Enzyme Linked Receptor Protein Signaling Pathway Blood Coagulation Platelet Activation Leukocyte Migration	Response To Hypoxia Acute-phase Response Inflammatory Response Complement Activation, Classical Pathway Aging Opsonization Response To Lead Ion Positive Regulation Of Gene Expression Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Lipid Storage Positive Regulation Of Superoxide Anion Generation Wound Healing Response To Ethanol Negative Regulation Of Vasodilation Defense Response To Gram-positive Bacterium Protein Polymerization Cellular Response To Calcium Ion Positive Regulation Of Dendrite Development Regulation Of Interleukin-8 Secretion
Pathways		Platelet Adhesion to exposed collagen GPVI-mediated activation cascade Platelet activation, signaling and aggregation Cell surface interactions at the vascular wall	Classical antibody-mediated complement activation Creation of C4 and C2 activators Complement cascade Initial triggering of complement Innate Immune System
Drugs			Phosphocholine
Diseases
GWAS		Platelet aggregation ( 20526338)	C-reactive protein ( 22492993 19567438 21647738 18439548 18439552 21196492 21300955 22939635) Inflammatory biomarkers ( 22291609) Lung cancer ( 18385676) Metabolic traits ( 19060910) Protein quantitative trait loci ( 18464913) Select biomarker traits ( 17903293)
Protein-Protein Interactions		7 interactors: CRP FCER1G FCGR2A FCGR3A FYN LYN YES1	20 interactors: APCS C1QA CFH DGCR14 FCGR1A FCGR2A FCGR2B FN1 GLUD1 GMPPA GP6 HIST1H1A HIST1H2AL HIST2H2AC LAMC3 LEP MAPK1 MAPK3 RPL13A SNRNP70
Entrez ID		51206	1401
HPRD ID		10406	00422
Ensembl ID		ENSG00000088053	ENSG00000132693
Uniprot IDs		Q9HCN6	P02741
PDB IDs		2GI7	1B09 1CRV 1GNH 1LJ7 3L2Y 3PVN 3PVO
Enriched GO Terms of Interacting Partners?		Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of Immune Response Endocytosis Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Immune System Process Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Immune Response Regulation Of Immune System Process Defense Response Vesicle-mediated Transport Innate Immune Response Immune System Process Peptidyl-tyrosine Autophosphorylation Wound Healing Leukocyte Migration Response To Wounding Positive Regulation Of Cell Activation T Cell Costimulation Response To Stress Ephrin Receptor Signaling Pathway Blood Coagulation Hemostasis Cellular Response To Platelet-derived Growth Factor Stimulus Response To Platelet-derived Growth Factor Regulation Of Cell Activation Regulation Of Body Fluid Levels Chemotaxis Platelet Activation Transport Protein Autophosphorylation Positive Regulation Of T Cell Activation Regulation Of Mast Cell Degranulation Positive Regulation Of Neuron Projection Development Production Of Molecular Mediator Involved In Inflammatory Response Positive Regulation Of Homotypic Cell-cell Adhesion Fc-epsilon Receptor Signaling Pathway Regulation Of Platelet Activation Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell-cell Adhesion Mast Cell Activation Regulation Of Mast Cell Activation Leukocyte Mediated Immunity Cell Migration Response To External Stimulus	Immune System Process Innate Immune Response Immune Response Regulation Of Immune System Process Defense Response Regulation Of Golgi Inheritance Regulation Of Immune Response Positive Regulation Of Immune System Process Caveolin-mediated Endocytosis Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of Immune Response JAK-STAT Cascade Regulation Of Golgi Organization Platelet Activation Response To Stress Regulation Of Early Endosome To Late Endosome Transport Phagocytosis Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Cellular Response To Cytokine Stimulus JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Growth Hormone Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Response To Cytokine Response To Epidermal Growth Factor Regulation Of Cellular Response To Heat Blood Coagulation Hemostasis Lipopolysaccharide-mediated Signaling Pathway Acute-phase Response Immune Response-regulating Signaling Pathway Response To Growth Hormone Response To Exogenous DsRNA Leukocyte Migration Negative Regulation Of Formation Of Translation Preinitiation Complex Positive Regulation Of Luteinizing Hormone Secretion Negative Regulation Of Glutamine Transport Negative Regulation Of Apolipoprotein Binding Cellular Response To L-ascorbic Acid Toll-like Receptor 5 Signaling Pathway Viral Process Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Regulation Of Body Fluid Levels Toll-like Receptor 9 Signaling Pathway
Tagcloud ?		acetyl antiviral arrested assayed baculovirus classical csfv designated excluded fever flavivirus galactopyranosyl glucopyranosyl glycoproteins glycosylation insect investigating nitro pyridyl rns round sk6 steps sulfoxide swine tetra thio tri unrelated	antibiotic appropriate children chosen circulating cutoff detectable febrile fell fever greatly helpful il involving lasting necrosis none pediatric pg pneumonia probable rather remained sequential syndrome tnf tool uti viral
Tagcloud (Difference) ?		acetyl antiviral arrested assayed baculovirus classical csfv designated excluded flavivirus galactopyranosyl glucopyranosyl glycoproteins glycosylation insect investigating nitro pyridyl rns round sk6 steps sulfoxide swine tetra thio tri unrelated	antibiotic appropriate children chosen circulating cutoff detectable febrile fell greatly helpful il involving lasting necrosis none pediatric pg pneumonia probable rather remained sequential syndrome tnf tool uti viral
Tagcloud (Intersection) ?		fever