GP6 and FCER1G

Number of citations of the paper that reports this interaction (PMID 10825177)
37

Data Source:
HPRD (in vitro, in vivo)

		GP6	FCER1G
Gene Name		glycoprotein VI (platelet)	Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Extracellular Vesicular Exosome Tetraspanin-enriched Microdomain	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Fc-epsilon Receptor I Complex
	Molecular Function	Receptor Activity Transmembrane Signaling Receptor Activity Protein Binding Collagen Binding	Protein Binding IgE Receptor Activity IgE Binding IgG Binding
	Biological Process	Enzyme Linked Receptor Protein Signaling Pathway Blood Coagulation Platelet Activation Leukocyte Migration	Positive Regulation Of Type IIa Hypersensitivity Positive Regulation Of Type III Hypersensitivity Positive Regulation Of Type I Hypersensitivity Neutrophil Activation Involved In Immune Response Fc Receptor Mediated Stimulatory Signaling Pathway Serotonin Secretion By Platelet Phagocytosis, Engulfment Integrin-mediated Signaling Pathway Blood Coagulation Regulation Of Platelet Activation Immunoglobulin Mediated Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Platelet Activation Neutrophil Chemotaxis Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Mast Cell Cytokine Production Negative Regulation Of Mast Cell Apoptotic Process Fc-epsilon Receptor Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Defense Response To Bacterium Positive Regulation Of Mast Cell Degranulation Innate Immune Response Mast Cell Activation Positive Regulation Of Phagocytosis Leukocyte Migration Protein Localization To Plasma Membrane
Pathways		Platelet Adhesion to exposed collagen GPVI-mediated activation cascade Platelet activation, signaling and aggregation Cell surface interactions at the vascular wall	Platelet Adhesion to exposed collagen FCERI mediated NF-kB activation GPVI-mediated activation cascade Fc epsilon receptor (FCERI) signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization Platelet activation, signaling and aggregation Role of LAT2/NTAL/LAB on calcium mobilization Cell surface interactions at the vascular wall Innate Immune System
Drugs			Benzylpenicilloyl Polylysine
Diseases
GWAS		Platelet aggregation ( 20526338)
Protein-Protein Interactions		7 interactors: CRP FCER1G FCGR2A FCGR3A FYN LYN YES1	8 interactors: FCER1A FCGR3A GP6 KIR2DL4 LYN NCR1 PLCG2 SYK
Entrez ID		51206	2207
HPRD ID		10406	00916
Ensembl ID		ENSG00000088053	ENSG00000158869
Uniprot IDs		Q9HCN6	P30273
PDB IDs		2GI7
Enriched GO Terms of Interacting Partners?		Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of Immune Response Endocytosis Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Immune Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Immune System Process Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Immune Response Regulation Of Immune System Process Defense Response Vesicle-mediated Transport Innate Immune Response Immune System Process Peptidyl-tyrosine Autophosphorylation Wound Healing Leukocyte Migration Response To Wounding Positive Regulation Of Cell Activation T Cell Costimulation Response To Stress Ephrin Receptor Signaling Pathway Blood Coagulation Hemostasis Cellular Response To Platelet-derived Growth Factor Stimulus Response To Platelet-derived Growth Factor Regulation Of Cell Activation Regulation Of Body Fluid Levels Chemotaxis Platelet Activation Transport Protein Autophosphorylation Positive Regulation Of T Cell Activation Regulation Of Mast Cell Degranulation Positive Regulation Of Neuron Projection Development Production Of Molecular Mediator Involved In Inflammatory Response Positive Regulation Of Homotypic Cell-cell Adhesion Fc-epsilon Receptor Signaling Pathway Regulation Of Platelet Activation Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell-cell Adhesion Mast Cell Activation Regulation Of Mast Cell Activation Leukocyte Mediated Immunity Cell Migration Response To External Stimulus	Regulation Of Immune Response Fc Receptor Signaling Pathway Regulation Of Immune System Process Defense Response Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Mast Cell Degranulation Positive Regulation Of Interleukin-3 Biosynthetic Process Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Mast Cell Activation B Cell Receptor Signaling Pathway Regulation Of Regulated Secretory Pathway Response To Stress Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process Platelet Activation Immune System Process Regulation Of Granulocyte Macrophage Colony-stimulating Factor Biosynthetic Process Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Immune Response Serotonin Secretion Phagocytosis Cell Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Ammonium Transport Serotonin Transport Innate Immune Response Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Immune System Process Signal Transduction Blood Coagulation Hemostasis Positive Regulation Of Mast Cell Degranulation Positive Regulation Of Mast Cell Activation Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Signaling Leukocyte Activation Regulation Of Platelet Aggregation Cell Communication Regulation Of Exocytosis Leukocyte Activation Involved In Immune Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Regulated Secretory Pathway Regulation Of Body Fluid Levels Immune Response Leukotriene Biosynthetic Process Wound Healing Monoamine Transport
Tagcloud ?		acetyl antiviral arrested assayed baculovirus classical csfv designated excluded fever flavivirus galactopyranosyl glucopyranosyl glycoproteins glycosylation insect investigating nitro pyridyl rns round sk6 steps sulfoxide swine tetra thio tri unrelated
Tagcloud (Difference) ?		acetyl antiviral arrested assayed baculovirus classical csfv designated excluded fever flavivirus galactopyranosyl glucopyranosyl glycoproteins glycosylation insect investigating nitro pyridyl rns round sk6 steps sulfoxide swine tetra thio tri unrelated
Tagcloud (Intersection) ?