XPC and ABCA1

Number of citations of the paper that reports this interaction (PMID 12505994)
18

Data Source:
BioGRID (two hybrid)

		XPC	ABCA1
Gene Name		xeroderma pigmentosum, complementation group C	ATP-binding cassette, sub-family A (ABC1), member 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Plasma Membrane Extracellular Vesicular Exosome XPC Complex	Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Endocytic Vesicle High-density Lipoprotein Particle Membrane Raft Phagocytic Vesicle Perinuclear Region Of Cytoplasm
	Molecular Function	Heteroduplex DNA Loop Binding Bubble DNA Binding Damaged DNA Binding Single-stranded DNA Binding Protein Binding	Receptor Binding Protein Binding ATP Binding Phospholipid Binding Phospholipid Transporter Activity Anion Transmembrane Transporter Activity Cholesterol Binding ATPase Activity Cholesterol Transporter Activity Syntaxin Binding Small GTPase Binding Apolipoprotein Binding Apolipoprotein A-I Binding Apolipoprotein A-I Receptor Activity ATPase Binding
	Biological Process	Nucleotide-excision Repair, DNA Damage Recognition Nucleotide-excision Repair, DNA Damage Removal DNA Repair Nucleotide-excision Repair Response To UV-B Intra-S DNA Damage Checkpoint Response To Drug Regulation Of Mitotic Cell Cycle Phase Transition	Peptide Secretion Protein Lipidation Phagocytosis, Engulfment Lysosome Organization G-protein Coupled Receptor Signaling Pathway Response To Nutrient Cholesterol Metabolic Process Negative Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Efflux Negative Regulation Of Cholesterol Storage Endosomal Transport Positive Regulation Of CAMP Biosynthetic Process Intracellular Cholesterol Transport Regulation Of Cdc42 Protein Signal Transduction Cholesterol Efflux Phospholipid Efflux High-density Lipoprotein Particle Assembly Response To Laminar Fluid Shear Stress Apolipoprotein A-I-mediated Signaling Pathway Lipoprotein Metabolic Process Response To Drug Cholesterol Homeostasis Reverse Cholesterol Transport Cellular Lipid Metabolic Process Small Molecule Metabolic Process Phospholipid Translocation Interleukin-1 Beta Secretion Phospholipid Homeostasis Response To Low-density Lipoprotein Particle Platelet Dense Granule Organization Cellular Response To Lipopolysaccharide Cellular Response To Retinoic Acid Cellular Response To Cholesterol
Pathways		Nucleotide Excision Repair Global Genomic NER (GG-NER) Formation of incision complex in GG-NER DNA Damage Recognition in GG-NER Dual incision reaction in GG-NER	Lipoprotein metabolism PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism HDL-mediated lipid transport Metabolism of lipids and lipoproteins Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Lipid digestion, mobilization, and transport
Drugs			Adenosine triphosphate Glyburide Probucol
Diseases
GWAS			Cholesterol, total ( 20686565) Coronary heart disease ( 21347282) HDL cholesterol ( 21909109 18193043 18193044 20864672 19060906 23505323 19060911 20686565) Lipid metabolism phenotypes ( 22286219) Metabolic syndrome ( 22399527) Metabolite levels ( 22916037) MRI atrophy measures ( 21116278) Myopia (pathological) ( 23049088)
Protein-Protein Interactions		16 interactors: ABCA1 CETN2 DDB2 ERCC3 GTF2H1 LSM3 MDM2 PSMD4 RAD23A RAD23B RPA1 SMAD1 SUMO2 TDG USP7 ZNF512B	42 interactors: AOX1 APOA1 ARHGEF11 ARHGEF12 ATXN10 CSNK2A1 CSNK2A2 DLG2 DLG3 DLG5 ERBB2IP FADD GOPC IKBKG LIMK1 LIN7A LIN7B LIN7C LMO7 LNX1 MPDZ MPP6 PDLIM3 PDLIM4 PDZK1 PLTP PRKACA PRPF8 RAPGEF6 RIMS2 SDHB SHANK1 SLC25A34 SNTA1 SNTB1 SNTB2 SPTLC1 TGM2 TIAM1 TRIM27 UGP2 XPC
Entrez ID		7508	19
HPRD ID		02046	02501
Ensembl ID		ENSG00000154767	ENSG00000165029
Uniprot IDs		Q01831	B2RUU2 B7XCW9 O95477
PDB IDs		2A4J 2GGM 2OBH
Enriched GO Terms of Interacting Partners?		Nucleotide-excision Repair Cellular Response To DNA Damage Stimulus Cellular Macromolecule Catabolic Process Nucleotide-excision Repair, DNA Damage Removal DNA Repair Cellular Response To Stress DNA Catabolic Process Catabolic Process Response To Stress DNA Metabolic Process Aromatic Compound Catabolic Process Transcription-coupled Nucleotide-excision Repair Regulation Of Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Cellular Nitrogen Compound Metabolic Process Viral Process Cellular Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Proteolysis Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression, Epigenetic Cellular Protein Metabolic Process Cellular Response To Stimulus Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Positive Regulation Of Viral Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Proteasomal Protein Catabolic Process Cellular Protein Catabolic Process Chromosome Organization Protein Catabolic Process Cellular Protein Modification Process Response To UV Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Protein Metabolic Process Termination Of RNA Polymerase I Transcription Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Viral Process Transcription Elongation From RNA Polymerase I Promoter Regulation Of Cellular Protein Metabolic Process Response To Stimulus Transcription Initiation From RNA Polymerase I Promoter Metabolic Process 7-methylguanosine MRNA Capping Transcription From RNA Polymerase I Promoter Regulation Of Cell Cycle Process	Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Asymmetric Protein Localization Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Cell Polarity Protein Localization To Basolateral Plasma Membrane Maintenance Of Epithelial Cell Apical/basal Polarity Maintenance Of Apical/basal Cell Polarity Chemotaxis Neuron Projection Development Maintenance Of Cell Polarity Cell Projection Organization Protein Localization To Membrane Neuron Development Axon Guidance Axon Development Cell Morphogenesis Involved In Neuron Differentiation Protein Localization To Synapse Protein Localization To Plasma Membrane Cellular Component Assembly Protein Localization Cellular Protein Localization Neuron Projection Morphogenesis Nervous System Development Neuron Differentiation Regulation Of Catalytic Activity Signaling Cellular Localization Cell Morphogenesis Involved In Differentiation Cell Communication Axonogenesis Cell Development Response To External Stimulus Anatomical Structure Development Locomotion Plasma Membrane Organization Neurotransmitter Secretion Protein Complex Assembly System Development Cell Projection Morphogenesis Membrane Organization Cell Part Morphogenesis Endomembrane System Organization Regulation Of Neurotransmitter Levels Cell-cell Signaling Receptor Localization To Synapse Movement Of Cell Or Subcellular Component Developmental Process Apoptotic Process Generation Of Neurons Neurotransmitter Transport
Tagcloud ?			administrated amplitudes aspartic bace1 bax erg excitotoxicity gcl injection inl inner intravitreal lxr lxralpha lxrbeta lxrs neuroprotective neurotoxicity nevertheless nmda orally preserved protects retinal speculate to90 to901317 upregulated wave
Tagcloud (Difference) ?			administrated amplitudes aspartic bace1 bax erg excitotoxicity gcl injection inl inner intravitreal lxr lxralpha lxrbeta lxrs neuroprotective neurotoxicity nevertheless nmda orally preserved protects retinal speculate to90 to901317 upregulated wave
Tagcloud (Intersection) ?