CEP164

Description		centrosomal protein 164
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GO Annotations	Cellular Component	Extracellular Space Nucleus Nucleoplasm Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Ciliary Transition Fiber
	Molecular Function	Protein Binding
	Biological Process	DNA Repair DNA Damage Response Cell Projection Organization Cell Division Cilium Assembly
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Diastolic blood pressure ( 30578418) Diffusing capacity of carbon monoxide ( 30694715) Hematocrit ( 32888494) Hemoglobin levels ( 32327693) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Metabolite levels ( 23823483) Pulse pressure ( 27841878 28135244 30578418)
Novel Interacting Genes		1 novel interacting genes: ATP5MG
Interacting Genes		6 interacting genes: ATR ATRIP CLP1 MAPK14 UBC XPA
Entrez ID		22897
HPRD ID		10854
Ensembl ID		ENSG00000110274
Uniprot IDs		Q9UPV0
PDB IDs		7NWJ 7O06 7O0S 7O3B
Enriched GO Terms of Interacting Partners?		ATR-ATRIP Complex Cellular Response To UV Cellular Response To Light Stimulus DNA Damage Checkpoint Signaling Response To UV Signal Transduction In Response To DNA Damage Cellular Response To Radiation Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Cycle Phase Transition DNA Damage Response Negative Regulation Of Cell Cycle Process Response To Light Stimulus Negative Regulation Of Cell Cycle Cellular Response To Ionizing Radiation Nucleic Acid Metabolic Process Nucleotide-excision Repair, DNA Damage Recognition Response To Radiation Regulation Of Cell Cycle Phase Transition Establishment Of Protein-containing Complex Localization To Telomere Nucleoplasm Establishment Of RNA Localization To Telomere Positive Regulation Of Telomerase Catalytic Core Complex Assembly Nucleotide-excision Repair Involved In Interstrand Cross-link Repair ATP-dependent Polyribonucleotide 5'-hydroxyl-kinase Activity Polynucleotide 5'-hydroxyl-kinase Activity ATP-dependent Polynucleotide 5'-hydroxyl-kinase Activity DNA Repair Histone H2AXS139 Kinase Activity Regulation Of Synaptic Membrane Adhesion Nucleotide-excision Repair Factor 1 Complex Global Gene Silencing By MRNA Cleavage Kinase Activity Response To Ionizing Radiation Regulation Of Double-strand Break Repair TRNA-intron Endonuclease Complex ATP-dependent Polydeoxyribonucleotide 5'-hydroxyl-kinase Activity Cellular Response To Stress DNA Metabolic Process Regulation Of Cell Cycle Process NFAT Protein Binding MRNA Cleavage Factor Complex Response To Mechanical Stimulus MutSalpha Complex Binding Macromolecule Metabolic Process MutLalpha Complex Binding Mitogen-activated Protein Kinase P38 Binding Stress-induced Premature Senescence Cerebellar Cortex Development Intracellular Signal Transduction NLRP1 Inflammasome Complex Assembly
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