CORO2A and TBL1X

Number of citations of the paper that reports this interaction (PMID 12628926)
122

Data Source:
HPRD (in vitro)

		CORO2A	TBL1X
Gene Name		coronin, actin binding protein, 2A	transducin (beta)-like 1X-linked
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Actin Cytoskeleton Transcriptional Repressor Complex	Histone Deacetylase Complex Nucleus Nucleoplasm Spindle Microtubule Transcriptional Repressor Complex
	Molecular Function	Actin Filament Binding	Transcription Corepressor Activity Protein Binding Beta-catenin Binding Protein C-terminus Binding Transcription Factor Binding Protein Domain Specific Binding Histone Binding Transcription Regulatory Region DNA Binding
	Biological Process	Actin Cytoskeleton Organization Intracellular Signal Transduction	Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Organization Transcription, DNA-templated Proteolysis Notch Signaling Pathway Sensory Perception Of Sound Histone Deacetylation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Canonical Wnt Signaling Pathway
Pathways			Signaling by NOTCH1 HD Domain Mutants in Cancer PPARA activates gene expression Organelle biogenesis and maintenance Metabolism of lipids and lipoproteins Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer RORA activates circadian gene expression Regulation of cholesterol biosynthesis by SREBP (SREBF) Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Generic Transcription Pathway Signaling by NOTCH1 Transcriptional regulation of white adipocyte differentiation Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Orphan transporters FBXW7 Mutants and NOTCH1 in Cancer Fatty acid, triacylglycerol, and ketone body metabolism Chromatin organization HDACs deacetylate histones Signaling by NOTCH REV-ERBA represses gene expression Mitochondrial biogenesis NOTCH1 Intracellular Domain Regulates Transcription Chromatin modifying enzymes Signaling by NOTCH1 PEST Domain Mutants in Cancer YAP1- and WWTR1 (TAZ)-stimulated gene expression Activation of gene expression by SREBF (SREBP) Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Transcriptional activation of mitochondrial biogenesis Constitutive Signaling by NOTCH1 PEST Domain Mutants BMAL1:CLOCK,NPAS2 activates circadian gene expression
Drugs
Diseases
GWAS			Prostate cancer ( 23535732)
Protein-Protein Interactions		5 interactors: HDAC3 SUMO2 TBL1X TBL1XR1 UBE2I	25 interactors: CDC34 CORO2A CTNNB1 DLX3 DNAJB4 GPS2 HDAC3 HIST1H4A HIST2H2AA3 HIST2H2BE HIST2H3C HIST2H4A HP HR KHDRBS1 NCOR1 NCOR2 SKP1 TAB2 TBL1XR1 TERF1 THRA THRB TINF2 UBE2D1
Entrez ID		7464	6907
HPRD ID		03695	02183
Ensembl ID		ENSG00000106789	ENSG00000101849
Uniprot IDs		A8K9S3 Q92828	O60907
PDB IDs			2XTC 2XTD 2XTE
Enriched GO Terms of Interacting Partners?		Histone Deacetylation Protein Deacetylation Notch Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter Protein Sumoylation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Histone Modification Negative Regulation Of Gene Expression Cellular Protein Modification Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Chromatin Modification Canonical Wnt Signaling Pathway Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of SUMO Transferase Activity Cellular Protein Metabolic Process Chromatin Organization Negative Regulation Of Cellular Metabolic Process Cellular Macromolecule Catabolic Process Cellular Lipid Metabolic Process Positive Regulation Of Cellular Metabolic Process Protein Metabolic Process Post-translational Protein Modification Positive Regulation Of Transcription From RNA Polymerase II Promoter Chromosome Organization Peptidyl-lysine Modification Wnt Signaling Pathway Organelle Organization Lipid Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Proteolysis Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of Metabolic Process Cellular Response To Fluid Shear Stress Catabolic Process Positive Regulation Of TOR Signaling Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription	Negative Regulation Of Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Chromatin Organization Chromosome Organization Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Type I Pneumocyte Differentiation Nucleobase-containing Compound Metabolic Process Lung Cell Differentiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Notch Signaling Pathway DNA Methylation On Cytosine Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Chromatin Silencing At RDNA Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Telomere Maintenance Gene Expression Regulation Of Chromosome Organization Chromatin Modification Nitrogen Compound Metabolic Process Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Female Courtship Behavior DNA-templated Transcription, Initiation Organelle Organization Negative Regulation Of JNK Cascade Histone H4-K20 Demethylation Cell Cycle Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Stress-activated MAPK Cascade Chromatin Silencing Transcription, DNA-templated Mitotic Cell Cycle RNA Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Megakaryocyte Differentiation Negative Regulation Of Telomere Maintenance Via Telomerase Cellular Macromolecule Biosynthetic Process Lung Epithelial Cell Differentiation
Tagcloud ?		6v3 akr1c2 amongst appearing bard1 beadchip bisulfite cdf15 cobra cyrillic5 diagnostics dnajc12 hook1 humanwd illumina interrogated normalcy ntrk4 pppqr1b s100p sentrix sfrp1 tff1 timp4 top2a tp53ink1 tusc5 tuscapital unmethylated	c1qdc1 cds1 crebbp ctnnd1 cul1 customized dner eef2 eif2ak2 fzd2 fzd9 g93a gastrocnemius id2 inppl1 keep loxl2 neuromuscular pi3 pik3c2a pik4ca piki3r1 precede presymptomatic prkx rac3 ripk4 snf1lk sod1
Tagcloud (Difference) ?		6v3 akr1c2 amongst appearing bard1 beadchip bisulfite cdf15 cobra cyrillic5 diagnostics dnajc12 hook1 humanwd illumina interrogated normalcy ntrk4 pppqr1b s100p sentrix sfrp1 tff1 timp4 top2a tp53ink1 tusc5 tuscapital unmethylated	c1qdc1 cds1 crebbp ctnnd1 cul1 customized dner eef2 eif2ak2 fzd2 fzd9 g93a gastrocnemius id2 inppl1 keep loxl2 neuromuscular pi3 pik3c2a pik4ca piki3r1 precede presymptomatic prkx rac3 ripk4 snf1lk sod1
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