CORO2A and TBL1XR1

Number of citations of the paper that reports this interaction (PMID 12628926)
122

Data Source:
HPRD (in vitro)

		CORO2A	TBL1XR1
Gene Name		coronin, actin binding protein, 2A	transducin (beta)-like 1 X-linked receptor 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Actin Cytoskeleton Transcriptional Repressor Complex	Histone Deacetylase Complex Nucleus Nucleoplasm Spindle Microtubule Transcriptional Repressor Complex
	Molecular Function	Actin Filament Binding	Transcription Corepressor Activity Protein Binding Beta-catenin Binding Histone Binding Transcription Regulatory Region DNA Binding Protein N-terminus Binding
	Biological Process	Actin Cytoskeleton Organization Intracellular Signal Transduction	Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Organization Transcription, DNA-templated Notch Signaling Pathway Histone Deacetylation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Canonical Wnt Signaling Pathway
Pathways			Signaling by NOTCH1 HD Domain Mutants in Cancer PPARA activates gene expression Organelle biogenesis and maintenance Metabolism of lipids and lipoproteins Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer RORA activates circadian gene expression Regulation of cholesterol biosynthesis by SREBP (SREBF) Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Generic Transcription Pathway Signaling by NOTCH1 Transcriptional regulation of white adipocyte differentiation Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Orphan transporters FBXW7 Mutants and NOTCH1 in Cancer Fatty acid, triacylglycerol, and ketone body metabolism Chromatin organization HDACs deacetylate histones Signaling by NOTCH REV-ERBA represses gene expression Mitochondrial biogenesis NOTCH1 Intracellular Domain Regulates Transcription Chromatin modifying enzymes Signaling by NOTCH1 PEST Domain Mutants in Cancer YAP1- and WWTR1 (TAZ)-stimulated gene expression Activation of gene expression by SREBF (SREBP) Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Transcriptional activation of mitochondrial biogenesis Constitutive Signaling by NOTCH1 PEST Domain Mutants BMAL1:CLOCK,NPAS2 activates circadian gene expression
Drugs
Diseases
GWAS			Corneal structure ( 23291589) Esophageal cancer ( 21642993)
Protein-Protein Interactions		5 interactors: HDAC3 SUMO2 TBL1X TBL1XR1 UBE2I	9 interactors: ARL2 CORO2A GPS2 HDAC3 HIST1H4F HIST2H2BE HIST2H4A NCOR1 TBL1X
Entrez ID		7464	79718
HPRD ID		03695	15476
Ensembl ID		ENSG00000106789	ENSG00000177565
Uniprot IDs		A8K9S3 Q92828	Q9BZK7
PDB IDs
Enriched GO Terms of Interacting Partners?		Histone Deacetylation Protein Deacetylation Notch Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter Protein Sumoylation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Histone Modification Negative Regulation Of Gene Expression Cellular Protein Modification Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Chromatin Modification Canonical Wnt Signaling Pathway Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of SUMO Transferase Activity Cellular Protein Metabolic Process Chromatin Organization Negative Regulation Of Cellular Metabolic Process Cellular Macromolecule Catabolic Process Cellular Lipid Metabolic Process Positive Regulation Of Cellular Metabolic Process Protein Metabolic Process Post-translational Protein Modification Positive Regulation Of Transcription From RNA Polymerase II Promoter Chromosome Organization Peptidyl-lysine Modification Wnt Signaling Pathway Organelle Organization Lipid Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Proteolysis Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of Metabolic Process Cellular Response To Fluid Shear Stress Catabolic Process Positive Regulation Of TOR Signaling Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription	Chromatin Organization Chromosome Organization Organelle Organization Negative Regulation Of JNK Cascade Negative Regulation Of Stress-activated MAPK Cascade Protein Complex Assembly Histone H4-K20 Demethylation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Modification Negative Regulation Of Megakaryocyte Differentiation Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Cell Cycle Negative Regulation Of Hematopoietic Progenitor Cell Differentiation DNA Replication-dependent Nucleosome Assembly Histone Modification DNA Methylation On Cytosine Nucleosome Assembly Chromatin Assembly Notch Signaling Pathway Chromatin Silencing At RDNA Cellular Component Assembly Nucleosome Organization Chromatin Assembly Or Disassembly Negative Regulation Of MAPK Cascade Regulation Of Megakaryocyte Differentiation Regulation Of JNK Cascade Protein-DNA Complex Assembly Negative Regulation Of Cellular Metabolic Process DNA Packaging Regulation Of Stress-activated MAPK Cascade CENP-A Containing Nucleosome Assembly Cellular Macromolecular Complex Assembly Regulation Of Hematopoietic Progenitor Cell Differentiation Histone Exchange Chromatin Silencing DNA Replication-independent Nucleosome Assembly Histone Lysine Demethylation Histone Demethylation Protein Demethylation Negative Regulation Of Transcription From RNA Polymerase II Promoter DNA Conformation Change Centromere Complex Assembly DNA Methylation Histone Deacetylation Demethylation Protein Deacetylation ATP-dependent Chromatin Remodeling
Tagcloud ?		6v3 akr1c2 amongst appearing bard1 beadchip bisulfite cdf15 cobra cyrillic5 diagnostics dnajc12 hook1 humanwd illumina interrogated normalcy ntrk4 pppqr1b s100p sentrix sfrp1 tff1 timp4 top2a tp53ink1 tusc5 tuscapital unmethylated	7ralpha aberrations abl1 bcp btg1 cofactors complemented concerted cooperating crlf2 deletions deregulated determinants drive e2a ebf1 hematological ikzf1 ink4a insufficient lineage lymphoblastic master overview pax5 prb runx1 specification translocations
Tagcloud (Difference) ?		6v3 akr1c2 amongst appearing bard1 beadchip bisulfite cdf15 cobra cyrillic5 diagnostics dnajc12 hook1 humanwd illumina interrogated normalcy ntrk4 pppqr1b s100p sentrix sfrp1 tff1 timp4 top2a tp53ink1 tusc5 tuscapital unmethylated	7ralpha aberrations abl1 bcp btg1 cofactors complemented concerted cooperating crlf2 deletions deregulated determinants drive e2a ebf1 hematological ikzf1 ink4a insufficient lineage lymphoblastic master overview pax5 prb runx1 specification translocations
Tagcloud (Intersection) ?