CORO2A and NRAS

Number of citations of the paper that reports this interaction (PubMedID 24412244)
0

Data Source:
BioGRID (two hybrid)

		CORO2A	NRAS
Description		coronin 2A	NRAS proto-oncogene, GTPase
Image		No pdb structure
GO Annotations	Cellular Component	Brush Border Transcription Repressor Complex	Golgi Membrane Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Membrane Extracellular Exosome Tertiary Granule Membrane
	Molecular Function	Actin Binding Protein Binding Actin Filament Binding	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Protein-containing Complex Binding
	Biological Process	Intracellular Signal Transduction	MAPK Cascade Positive Regulation Of Endothelial Cell Proliferation Signal Transduction Ras Protein Signal Transduction
Pathways			SOS-mediated signalling Activation of RAS in B cells Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants SHC1 events in ERBB2 signaling SHC1 events in ERBB4 signaling Signaling by SCF-KIT Signalling to RAS p38MAPK events p38MAPK events GRB2 events in EGFR signaling SHC1 events in EGFR signaling Downstream signal transduction GRB2 events in ERBB2 signaling GRB2 events in ERBB2 signaling Tie2 Signaling EGFR Transactivation by Gastrin DAP12 signaling SHC-related events triggered by IGF1R FCERI mediated MAPK activation NCAM signaling for neurite out-growth Ras activation upon Ca2+ influx through NMDA receptor VEGFR2 mediated cell proliferation CD209 (DC-SIGN) signaling Constitutive Signaling by EGFRvIII SHC-mediated cascade:FGFR1 FRS-mediated FGFR1 signaling SHC-mediated cascade:FGFR2 FRS-mediated FGFR2 signaling SHC-mediated cascade:FGFR3 FRS-mediated FGFR3 signaling FRS-mediated FGFR4 signaling SHC-mediated cascade:FGFR4 Signaling by FGFR2 in disease Signaling by FGFR4 in disease Signaling by FGFR1 in disease Signaling by FGFR3 in disease Regulation of RAS by GAPs RAF activation RAF/MAP kinase cascade MAP2K and MAPK activation Negative regulation of MAPK pathway Neutrophil degranulation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions RAS signaling downstream of NF1 loss-of-function variants Paradoxical activation of RAF signaling by kinase inactive BRAF Insulin receptor signalling cascade PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases MET activates RAS signaling Activated NTRK2 signals through RAS Erythropoietin activates RAS Activated NTRK2 signals through FRS2 and FRS3 Activated NTRK3 signals through RAS FLT3 Signaling Constitutive Signaling by Overexpressed ERBB2 Estrogen-stimulated signaling through PRKCZ RAS processing Signaling downstream of RAS mutants Signaling by RAF1 mutants Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants Signaling by PDGFRA extracellular domain mutants Signaling by FLT3 fusion proteins Signaling by FLT3 ITD and TKD mutants Signaling by RAS GAP mutants Signaling by RAS GTPase mutants
Drugs
Diseases			Adrenal carcinoma Acute myeloid leukemia (AML) Oral cancer Multiple myeloma Malignant melanoma Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS) Hepatocellular carcinoma Thyroid cancer Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases: CD95 (Fas) defect, ALPS type 1a; CD95L (Fas ligand) defect, ALPS type 1b; Caspase 10 defect, ALPS type 2a; Caspase 8 defext, ALPS type 2b; Activaing N-Ras defect, N-Ras ALPS
GWAS		Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962)	Adult body size ( 32376654) Autism ( 24189344)
Interacting Genes		12 interacting genes: AURKA BUB1 DCC DLC1 HDAC3 NRAS RB1 RSPH1 SMAD2 TBL1X TBL1XR1 UBE2I	48 interacting genes: ACVR1 AKT1 ALDOB AOPEP ARAF ARHGAP4 BCL2 CCDC180 CORO2A CYLC2 DNAJB1 EEF1A1 FANCC FBP2 FRAT2 HEMGN HRAS ITCH LEF1 LZTR1 MAPK3 MAPKAP1 MTOR NEDD4 PIK3CA PIK3CG PLCE1 PPP2CB RACGAP1 RAF1 RAP1GDS1 RASGRP2 RASSF5 RGL2 RGL3 RPS20 SFRP4 SHOC2 SMAD1 SMAD4 SMURF2 SRI STX17 TDRD7 TRMO WDR76 XPA ZDHHC9
Entrez ID		7464	4893
HPRD ID		03695	01273
Ensembl ID		ENSG00000106789	ENSG00000213281
Uniprot IDs		A8K9S3 Q92828	P01111 Q5U091
PDB IDs			2N9C 3CON 5UHV 6E6H 6MPP 6ULI 6ULK 6ULN 6ULR 6UON 6WGH 6ZIO 6ZIR 6ZIZ 7F68 7OW3 7OW4 7OW5 7OW6 7PB2 8TBI 8VM2
Enriched GO Terms of Interacting Partners?		Mitotic Spindle Histone Deacetylase Complex Transcription Corepressor Activity Transcription Repressor Complex Meiotic Spindle Regulation Of Mitotic Nuclear Division Regulation Of Nuclear Division Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of DNA-templated Transcription Disordered Domain Specific Binding Negative Regulation Of RNA Biosynthetic Process Cell Division Chromatin Organization Aortic Valve Morphogenesis Negative Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Binding Regulation Of Mitotic Cell Cycle Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Signal Transduction Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Centromeric Histone H2A Kinase Activity Negative Regulation Of Biosynthetic Process Positive Regulation Of Mitotic Nuclear Division Regulation Of Epithelial Cell Apoptotic Process Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process SUMO Conjugating Enzyme Activity Positive Regulation Of Ferroptosis Heart Valve Morphogenesis Membrane Assembly Positive Regulation Of Cell Cycle Process Regulation Of Mitotic Sister Chromatid Separation Cytosol Chromatin Remodeling Negative Regulation Of Macromolecule Metabolic Process Regulation Of Chromosome Separation Negative Regulation Of Cell Differentiation P450-containing Electron Transport Chain Homomeric SMAD Protein Complex Ubiquitin Protein Ligase Binding Axis Specification Proteolysis Involved In Protein Catabolic Process Protein De-2-hydroxyisobutyrylase Activity Hindbrain Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II Ras Protein Signal Transduction Positive Regulation Of Cell Cycle	Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Intracellular Signaling Cassette Insulin Receptor Signaling Pathway Signal Transduction Regulation Of Signal Transduction Cytosol Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Signal Transduction Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cytoplasm Regulation Of Small GTPase Mediated Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Population Proliferation Cell Surface Receptor Signaling Pathway Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction ERBB Signaling Pathway Ras Protein Signal Transduction Positive Regulation Of Cell Migration BMP Signaling Pathway MAPK Cascade Positive Regulation Of Cell Motility Anoikis Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Locomotion Regulation Of Cellular Component Organization Channel Inhibitor Activity Programmed Cell Death Cellular Response To Insulin Stimulus Regulation Of Protein Catabolic Process Regulation Of Autophagy Cell Death Small GTPase-mediated Signal Transduction Regulation Of Ras Protein Signal Transduction Cellular Response To Peptide Hormone Stimulus Gland Development Negative Regulation Of Autophagy Protein Serine/threonine Kinase Activity Regulation Of Cell Growth Lymphocyte Proliferation Schwann Cell Development
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