PSMA1 and COX2

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		PSMA1	COX2
Gene Name		proteasome (prosome, macropain) subunit, alpha type, 1	cytochrome c oxidase subunit II
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Proteasome Complex Nucleus Nucleoplasm Centrosome Cytosol Proteasome Core Complex Polysome Proteasome Core Complex, Alpha-subunit Complex Extracellular Vesicular Exosome
	Molecular Function	RNA Binding Threonine-type Endopeptidase Activity Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination Mitotic Cell Cycle Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Regulation Of Cellular Amino Acid Metabolic Process Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Gene Expression Viral Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Nitrogen Compound Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Small Molecule Metabolic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		Hedgehog 'off' state misspliced GSK3beta mutants stabilize beta-catenin Hh ligand biogenesis disease T41 mutants of beta-catenin aren't phosphorylated Downstream signaling events of B Cell Receptor (BCR) Degradation of beta-catenin by the destruction complex Stabilization of p53 S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling Removal of licensing factors from origins Switching of origins to a post-replicative state Mitotic G1-G1/S phases Regulation of mRNA stability by proteins that bind AU-rich elements misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling DNA Replication Pre-Initiation S45 mutants of beta-catenin aren't phosphorylated APC/C:Cdc20 mediated degradation of mitotic proteins Regulation of APC/C activators between G1/S and early anaphase SCF(Skp2)-mediated degradation of p27/p21 deletions in the AMER1 gene destabilize the destruction complex Autodegradation of the E3 ubiquitin ligase COP1 AMER1 mutants destabilize the destruction complex Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint PCP/CE pathway Adaptive Immune System CDK-mediated phosphorylation and removal of Cdc6 Hedgehog ligand biogenesis APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Separation of Sister Chromatids HIV Infection Ubiquitin-dependent degradation of Cyclin D APC truncation mutants have impaired AXIN binding Assembly of the pre-replicative complex Autodegradation of Cdh1 by Cdh1:APC/C p53-Dependent G1 DNA Damage Response S37 mutants of beta-catenin aren't phosphorylated XAV939 inhibits tankyrase, stabilizing AXIN p53-Independent DNA Damage Response p53-Independent G1/S DNA damage checkpoint G1/S DNA Damage Checkpoints Vpu mediated degradation of CD4 Synthesis of DNA M/G1 Transition Ubiquitin-dependent degradation of Cyclin D1 TCF dependent signaling in response to WNT SCF-beta-TrCP mediated degradation of Emi1 degradation of AXIN Signaling by Hedgehog Regulation of mitotic cell cycle Degradation of GLI1 by the proteasome degradation of DVL Cell Cycle Checkpoints Signaling by WNT in cancer GLI3 is processed to GLI3R by the proteasome Regulation of Apoptosis Degradation of GLI2 by the proteasome Signaling by the B Cell Receptor (BCR) Vif-mediated degradation of APOBEC3G Ubiquitin Mediated Degradation of Phosphorylated Cdc25A p53-Dependent G1/S DNA damage checkpoint truncated APC mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP Signaling by Wnt Cyclin E associated events during G1/S transition APC/C:Cdc20 mediated degradation of Securin AUF1 (hnRNP D0) destabilizes mRNA CDK-mediated phosphorylation and removal of Cdc6 RNF mutants show enhanced WNT signaling and proliferation G1/S Transition truncations of AMER1 destabilize the destruction complex Processing-defective Hh variants abrogate ligand secretion Host Interactions of HIV factors phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex Regulation of activated PAK-2p34 by proteasome mediated degradation AXIN missense mutants destabilize the destruction complex S Phase APC/C-mediated degradation of cell cycle proteins Cyclin A:Cdk2-associated events at S phase entry SCF(Skp2)-mediated degradation of p27/p21 Mitotic Metaphase and Anaphase Regulation of ornithine decarboxylase (ODC) Antigen processing: Ubiquitination & Proteasome degradation Orc1 removal from chromatin Mitotic Anaphase M Phase APC truncation mutants are not K63 polyubiquitinated Metabolism of amino acids and derivatives Hedgehog 'on' state Programmed Cell Death Class I MHC mediated antigen processing & presentation Regulation of DNA replication Cell Cycle, Mitotic beta-catenin independent WNT signaling Orc1 removal from chromatin Activation of NF-kappaB in B cells Asymmetric localization of PCP proteins deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Cross-presentation of soluble exogenous antigens (endosomes) Antigen processing-Cross presentation CDT1 association with the CDC6:ORC:origin complex ER-Phagosome pathway	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. Respiratory electron transport The citric acid (TCA) cycle and respiratory electron transport Orphan transporters
Drugs
Diseases
GWAS		Alzheimer's disease (cognitive decline) ( 23535033)
Protein-Protein Interactions		87 interactors: ABCD3 ABI3 ACTN1 APIP APP BLZF1 C11orf49 CALCOCO2 CBS CCDC102B CCDC85B CCNH CDA CEP70 CEP72 COIL COX2 DLEU1 EHMT2 GLTSCR2 GNPTAB GOLGA2 HOMER3 HSD17B14 IFT20 IKZF1 IKZF3 INO80E KCTD1 KCTD17 KCTD9 KRT15 KRT31 KRT38 KRT40 KRTAP5-9 LDB1 LDOC1 LZTS2 MAD1L1 MAPRE1 MAPRE3 MCM6 MID2 MKRN3 MLH1 MRFAP1L1 MTUS2 NECAB2 NMI NOTCH2NL PARK2 PLK1 PNMA1 PNMA2 PNMA5 POMP PRDM14 PSMA2 PSMA3 PSMA4 PSMA7 PSMB10 PSMB2 PSMB5 PSMB9 RAD54B REL ROPN1 SFMBT1 SH3BP4 SH3GLB1 SSX2IP TCF12 TCF4 TDO2 TNFAIP1 TNR TRAF1 TRIM10 TRIM23 TRIM27 TRIM42 TSC22D4 UBXN11 VCP VIM	8 interactors: CCNG1 ECT2 EGFR HRSP12 LIG4 PSMA1 RAD21 YWHAE
Entrez ID		5682	4513
HPRD ID		04170	02470
Ensembl ID		ENSG00000129084
Uniprot IDs		B4E0X6 P25786	P00403 Q7GXZ8
PDB IDs			3VRJ
Enriched GO Terms of Interacting Partners?		Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Mitotic Cell Cycle Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cell Cycle Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Cellular Protein Catabolic Process Positive Regulation Of Ligase Activity Cell Cycle Process Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Regulation Of Ubiquitin-protein Transferase Activity DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Positive Regulation Of Protein Ubiquitination Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Negative Regulation Of Mitotic Cell Cycle Phase Transition Mitotic Cell Cycle Process Protein Ubiquitination Negative Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Canonical Wnt Signaling Pathway Protein Modification By Small Protein Conjugation Mitotic Cell Cycle Checkpoint Regulation Of Mitotic Cell Cycle Phase Transition Mitotic G1 DNA Damage Checkpoint G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Catabolic Process Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Cell Cycle Arrest Regulation Of Cell Cycle Phase Transition Positive Regulation Of Proteolysis Protein Polyubiquitination DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Wnt Signaling Pathway Signal Transduction In Response To DNA Damage Mitotic DNA Damage Checkpoint Regulation Of Protein Ubiquitination Regulation Of Cell Cycle Arrest Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Mitotic DNA Integrity Checkpoint Negative Regulation Of Protein Ubiquitination	Cell Cycle Cell Cycle Process Mitotic Cell Cycle Process Regulation Of Apoptotic Process Mitotic Cell Cycle Cellular Response To Stress Regulation Of Cell Death Apoptotic Process Cell Division Programmed Cell Death Regulation Of Cellular Protein Metabolic Process Cell Death Death Response To Stress Regulation Of Protein Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Mitotic Cell Cycle Neurotrophin Signaling Pathway Positive Regulation Of Intracellular Transport Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Cellular Response To DNA Damage Stimulus Negative Regulation Of Apoptotic Process Response To Metal Ion Negative Regulation Of Programmed Cell Death Regulation Of Cell Cycle Central Nervous System Development Negative Regulation Of Cell Death Positive Regulation Of Fibroblast Proliferation Regulation Of Mitotic Cell Cycle Response To Abiotic Stimulus Regulation Of Intracellular Transport Alkanesulfonate Metabolic Process DNA Ligation Involved In DNA Recombination Negative Regulation Of Cell Cycle Response To Radiation Nervous System Development Response To Inorganic Substance Regulation Of Catalytic Activity Mitotic DNA Damage Checkpoint Positive Regulation Of Protein Import Into Nucleus Regulation Of Fibroblast Proliferation Positive Regulation Of Signal Transduction Mitotic DNA Integrity Checkpoint Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Nucleocytoplasmic Transport Viral Process Response To Calcium Ion
Tagcloud ?		20s alpha5 alpha6 alpha7 alphal apparatus cations dephosphorylation electrophoretic endonuclease endoribonuclease hydrolysates possession postranslational proteasomal proteasome proteasomes proteolysis psma3 psma5 psma6 ptm ribonucleoprotein rnase scarcely spectrometric tryptic utr varies	cadherin cancers cd44 center character characteristics chi2 clinic colon colorectal differentiated feature features gender histological hmlh1 hmsh2 ki meanwhile mucinous protection rates rectal right shanghai sided signet subsides vs
Tagcloud (Difference) ?		20s alpha5 alpha6 alpha7 alphal apparatus cations dephosphorylation electrophoretic endonuclease endoribonuclease hydrolysates possession postranslational proteasomal proteasome proteasomes proteolysis psma3 psma5 psma6 ptm ribonucleoprotein rnase scarcely spectrometric tryptic utr varies	cadherin cancers cd44 center character characteristics chi2 clinic colon colorectal differentiated feature features gender histological hmlh1 hmsh2 ki meanwhile mucinous protection rates rectal right shanghai sided signet subsides vs
Tagcloud (Intersection) ?