PSMA1 and KCTD17

Number of citations: 0 (PubMedID 16189514)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		PSMA1	KCTD17
Name		proteasome 20S subunit alpha 1	potassium channel tetramerization domain containing 17
Structure
GO Annotations	Cellular Component	Proteasome Complex Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Proteasome Core Complex Proteasome Core Complex, Alpha-subunit Complex Extracellular Exosome	Cytoplasm Endoplasmic Reticulum Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	Lipopolysaccharide Binding Protein Binding	Protein Binding Identical Protein Binding Cullin Family Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Immune System Process Negative Regulation Of Inflammatory Response To Antigenic Stimulus Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process	Cell Projection Organization Endoplasmic Reticulum Calcium Ion Homeostasis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cilium Assembly Protein Homooligomerization
Pathways		Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases Assembly of the pre-replicative complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling KEAP1-NFE2L2 pathway GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Degradation of CDH1 Somitogenesis Antigen processing: Ubiquitination & Proteasome degradation Proteasome assembly Proteasome assembly Antigen processing: Ub, ATP-independent proteasomal degradation GSK3B-mediated proteasomal degradation of PD-L1(CD274) SPOP-mediated proteasomal degradation of PD-L1(CD274) AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) Degradation of CRY and PER proteins Degradation of CRY and PER proteins Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	None
Drugs		(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE	None
GWAS		Alzheimer's disease (cognitive decline) ( 23535033 ) Bipolar disorder ( 31043756 ) Diastolic blood pressure ( 27841878 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) HDL cholesterol levels ( 32203549 ) High chromosomal aberration frequency (total) ( 31586183 ) Hip circumference adjusted for BMI ( 34021172 ) Hip index ( 34021172 ) Skin and soft tissue infections ( 33662382 ) Systolic blood pressure ( 27841878 ) Triglyceride levels ( 32154731 32203549 ) Vitamin D levels ( 25208829 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )	Hemoglobin levels ( 33491795 ) Iron status biomarkers (ferritin levels) ( 28334935 ) Liver iron content ( 34128465 ) Mean corpuscular hemoglobin concentration ( 28453575 ) Mean corpuscular volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Platelet distribution width ( 32888494 ) Red blood cell traits ( 23222517 )
Interacting Genes		173 interacting genes: ABCD3 ABI2 ABI3 ACTN1 ACTN2 AGR2 APIP APP BANF2 BLZF1 C22orf39 CABP5 CALCOCO2 CBS CCDC102B CCDC136 CCDC85B CCNH CDA CDKN2D CDR2 CEBPA CEP70 CEP72 CFAP206 CHMP1A CINP CIP2A COG4 COG6 COIL CRX CSTPP1 DCTD DCTPP1 DDIT4L DEF6 DLEU1 DRC12 DYDC1 DYNLT1 EHMT2 EIF4A3 EMSY ERBB2 FNDC11 GNPTAB GOLGA2 GOLGA6A GPHN GSDMD GUCD1 HEXIM2 HOMER3 HOMEZ HOOK2 HOXC11 HSD17B14 HSF2BP IFT20 IKZF1 IKZF3 INO80E IPO13 KAZN KCTD1 KCTD13 KCTD17 KCTD6 KCTD7 KCTD9 KHDRBS3 KRT13 KRT15 KRT19 KRT31 KRT34 KRT37 KRT38 KRT40 KRTAP1-1 KRTAP1-3 KRTAP4-1 KRTAP5-9 KRTAP6-3 LDB1 LDOC1 LINC00632 LMO2 LONRF1 LZTFL1 LZTS1 LZTS2 MAD1L1 MAPK1 MAPRE1 MAPRE3 MCM6 MDH2 MID2 MIEF1 MKNK2 MKRN3 MLH1 MRFAP1L1 MSANTD4 MT-CO2 MTUS2 NAB2 NBPF19 NECAB2 NME7 NMI NOP53 NOTCH2NLA PCBD1 PCYT2 PICK1 PLK1 PM20D2 PNMA1 PNMA2 PNMA5 POLR1C PPCDC PRDM14 PRIMPOL PRKN PRPH PSMA2 PSMA3 PSMA4 PSMA7 PSMB10 PSMB2 PSMB5 RAD54B RBCK1 REL RFC2 RGS19 ROPN1 SAT1 SFMBT1 SH3BP4 SH3GLB1 SLF2 SNCA SPDEF SSX2IP TCF12 TCF4 TDO2 TEKT4 TNFAIP1 TNR TRAF1 TRAF5 TRIM10 TRIM23 TRIM27 TRIM42 TRIM54 TSC22D4 UBD UBXN11 VCP VIM VMAC WTAP YPEL5 ZFAND1 ZMYND19	23 interacting genes: AQP1 CRK DMC1 FARS2 LAT LNX1 LRRC18 MGAT5B NCK2 NIF3L1 NUDT18 OR51E1 PLCG2 PSMA1 RBX1 RIN3 RWDD4 STK16 SUV39H2 TCHP TINF2 TUBGCP4 UBE2D1
Entrez ID		5682	79734
HPRD ID		04170	07764
Ensembl ID		ENSG00000129084	ENSG00000100379
Uniprot IDs		B4E0X6 P25786	A0A087WX35 Q8N5Z5
PDB IDs		4R3O 4R67 5A0Q 5GJQ 5GJR 5L4G 5LE5 5LEX 5LEY 5LEZ 5LF0 5LF1 5LF3 5LF4 5LF6 5LF7 5LN3 5M32 5T0C 5T0G 5T0H 5T0I 5T0J 5VFO 5VFP 5VFQ 5VFR 5VFS 5VFT 5VFU 6AVO 6E5B 6KWY 6MSB 6MSD 6MSE 6MSG 6MSH 6MSJ 6MSK 6R70 6REY 6RGQ 6WJD 6WJN 6XMJ 7AWE 7B12 7LXV 7NAN 7NAO 7NAP 7NAQ 7NHT 7PG9 7QXN 7QXP 7QXU 7QXW 7QXX 7QY7 7QYA 7QYB 7V5G 7V5M 7W37 7W38 7W39 7W3A 7W3B 7W3C 7W3F 7W3G 7W3H 7W3I 7W3J 7W3K 7W3M 8BZL 8CVR 8CVS 8CVT 8CXB 8JRI 8JRT 8JTI 8K0G 8QYJ 8QYL 8QYM 8QYN 8QYO 8QYS 8QZ9 8TM3 8TM4 8TM5 8TM6 8UD9 8USB 8USC 8YIX 8YIY 8YIZ 9E8G 9E8H 9E8I 9E8J 9E8K 9E8L 9E8N 9E8O 9E8Q 9HMN	5A6R
GO Terms Enriched among Interactors		Identical Protein Binding Protein Binding Cytoskeleton Intermediate Filament Proteasome Core Complex Keratin Filament Intermediate Filament Organization Structural Constituent Of Skin Epidermis Cytoplasm Supramolecular Fiber Organization Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Organelle Organization Proteasome Complex Cytosol Protein Homooligomerization Proteasome Core Complex, Alpha-subunit Complex Protein Complex Oligomerization Cytoskeleton Organization Protein Domain Specific Binding Aggresome Assembly Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Serine/threonine Kinase Binding Regulation Of Microtubule-based Process Inclusion Body Assembly Cytosine Metabolic Process Structural Molecule Activity Positive Regulation Of Protein K63-linked Deubiquitination Cullin Family Protein Binding Nucleus Proteasome Core Complex, Beta-subunit Complex Microtubule-based Process Positive Regulation Of Organelle Organization Ficolin-1-rich Granule Lumen Regulation Of Microtubule Cytoskeleton Organization Type III Intermediate Filament Cellular Response To Arsenite Ion Lung Goblet Cell Differentiation Mitotic Spindle Astral Microtubule End Protein Localization To Microtubule Centrosome Proteasomal Protein Catabolic Process Cellular Component Assembly Glial Cell Development Mitotic Spindle Pole Proteolysis Involved In Protein Catabolic Process Pseudopodium Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway	Signaling Receptor Complex Adaptor Activity Phosphotyrosine Residue Binding