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PSMA1 and ACTN2
Number of citations of the paper that reports this interaction (PubMedID
32296183
)
50
Data Source:
BioGRID
(two hybrid)
PSMA1
ACTN2
Description
proteasome 20S subunit alpha 1
actinin alpha 2
Image
GO Annotations
Cellular Component
Proteasome Complex
Nucleus
Nucleoplasm
Cytoplasm
Centrosome
Cytosol
Proteasome Core Complex
Proteasome Core Complex, Alpha-subunit Complex
Extracellular Exosome
Extracellular Region
Cytoplasm
Cytosol
Cytoskeleton
Actin Filament
Plasma Membrane
Focal Adhesion
Actin Cytoskeleton
Sarcomere
Z Disc
Cell Junction
Filopodium
Cortical Actin Cytoskeleton
Platelet Alpha Granule Lumen
Pseudopodium
Cell Projection
Dendritic Spine
Synapse
Extracellular Exosome
Postsynaptic Density Membrane
Postsynaptic Actin Cytoskeleton
Glutamatergic Synapse
Postsynaptic Density, Intracellular Component
Molecular Function
Lipopolysaccharide Binding
Protein Binding
Transcription Coactivator Activity
Actin Binding
Integrin Binding
Calcium Ion Binding
Protein Binding
Phosphatidylinositol-4,5-bisphosphate Binding
Cytoskeletal Protein Binding
Structural Constituent Of Muscle
Protein Domain Specific Binding
LIM Domain Binding
Titin Binding
Identical Protein Binding
Transmembrane Transporter Binding
Metal Ion Binding
Actin Filament Binding
FATZ Binding
Titin Z Domain Binding
Structural Constituent Of Postsynaptic Actin Cytoskeleton
Channel Activator Activity
Biological Process
Immune System Process
Negative Regulation Of Inflammatory Response To Antigenic Stimulus
Ubiquitin-dependent Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Cell Adhesion
Microspike Assembly
Actin Cytoskeleton Organization
Regulation Of Membrane Potential
Regulation Of Apoptotic Process
Negative Regulation Of Potassium Ion Transport
Positive Regulation Of Potassium Ion Transport
Sarcomere Organization
Positive Regulation Of DNA-templated Transcription
Focal Adhesion Assembly
Anatomical Structure Formation Involved In Morphogenesis
Actin Filament Uncapping
Muscle Cell Development
Cardiac Muscle Cell Development
Protein Localization To Plasma Membrane
Phospholipase C-activating Angiotensin-activated Signaling Pathway
Postsynaptic Actin Cytoskeleton Organization
Negative Regulation Of Protein Localization To Cell Surface
Positive Regulation Of Endocytic Recycling
Positive Regulation Of Cation Channel Activity
Pathways
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
ER-Phagosome pathway
ER-Phagosome pathway
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of activated PAK-2p34 by proteasome mediated degradation
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
Assembly of the pre-replicative complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G2/M Checkpoints
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
KEAP1-NFE2L2 pathway
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
Degradation of CDH1
Somitogenesis
Antigen processing: Ubiquitination & Proteasome degradation
Proteasome assembly
Proteasome assembly
Antigen processing: Ub, ATP-independent proteasomal degradation
GSK3B-mediated proteasomal degradation of PD-L1(CD274)
SPOP-mediated proteasomal degradation of PD-L1(CD274)
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
Degradation of CRY and PER proteins
Degradation of CRY and PER proteins
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Platelet degranulation
Nephrin family interactions
Striated Muscle Contraction
Unblocking of NMDA receptors, glutamate binding and activation
Unblocking of NMDA receptors, glutamate binding and activation
Ras activation upon Ca2+ influx through NMDA receptor
RAF/MAP kinase cascade
Assembly and cell surface presentation of NMDA receptors
Negative regulation of NMDA receptor-mediated neuronal transmission
Long-term potentiation
Drugs
(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE
Diseases
GWAS
Alzheimer's disease (cognitive decline) (
23535033
)
Bipolar disorder (
31043756
)
Diastolic blood pressure (
27841878
)
Femur bone mineral density x serum urate levels interaction (
34046847
)
HDL cholesterol levels (
32203549
)
High chromosomal aberration frequency (total) (
31586183
)
Hip circumference adjusted for BMI (
34021172
)
Hip index (
34021172
)
Skin and soft tissue infections (
33662382
)
Systolic blood pressure (
27841878
)
Triglyceride levels (
32154731
32203549
)
Vitamin D levels (
25208829
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Metabolite levels (
23823483
)
Periodontitis (CDC/AAP) (
24024966
)
Interacting Genes
173 interacting genes:
ABCD3
ABI2
ABI3
ACTN1
ACTN2
AGR2
APIP
APP
BANF2
BLZF1
C22orf39
CABP5
CALCOCO2
CBS
CCDC102B
CCDC136
CCDC85B
CCNH
CDA
CDKN2D
CDR2
CEBPA
CEP70
CEP72
CFAP206
CHMP1A
CINP
CIP2A
COG4
COG6
COIL
CRX
CSTPP1
DCTD
DCTPP1
DDIT4L
DEF6
DLEU1
DRC12
DYDC1
DYNLT1
EHMT2
EIF4A3
EMSY
ERBB2
FNDC11
GNPTAB
GOLGA2
GOLGA6A
GPHN
GSDMD
GUCD1
HEXIM2
HOMER3
HOMEZ
HOOK2
HOXC11
HSD17B14
HSF2BP
IFT20
IKZF1
IKZF3
INO80E
IPO13
KAZN
KCTD1
KCTD13
KCTD17
KCTD6
KCTD7
KCTD9
KHDRBS3
KRT13
KRT15
KRT19
KRT31
KRT34
KRT37
KRT38
KRT40
KRTAP1-1
KRTAP1-3
KRTAP4-1
KRTAP5-9
KRTAP6-3
LDB1
LDOC1
LINC00632
LMO2
LONRF1
LZTFL1
LZTS1
LZTS2
MAD1L1
MAPK1
MAPRE1
MAPRE3
MCM6
MDH2
MID2
MIEF1
MKNK2
MKRN3
MLH1
MRFAP1L1
MSANTD4
MT-CO2
MTUS2
NAB2
NBPF19
NECAB2
NME7
NMI
NOP53
NOTCH2NLA
PCBD1
PCYT2
PICK1
PLK1
PM20D2
PNMA1
PNMA2
PNMA5
POLR1C
PPCDC
PRDM14
PRIMPOL
PRKN
PRPH
PSMA2
PSMA3
PSMA4
PSMA7
PSMB10
PSMB2
PSMB5
RAD54B
RBCK1
REL
RFC2
RGS19
ROPN1
SAT1
SFMBT1
SH3BP4
SH3GLB1
SLF2
SNCA
SPDEF
SSX2IP
TCF12
TCF4
TDO2
TEKT4
TNFAIP1
TNR
TRAF1
TRAF5
TRIM10
TRIM23
TRIM27
TRIM42
TRIM54
TSC22D4
UBD
UBXN11
VCP
VIM
VMAC
WTAP
YPEL5
ZFAND1
ZMYND19
110 interacting genes:
ACTN3
ADAM12
ADORA2A
AKTIP
ANG
ANGPTL7
ARX
ASH2L
ATP5MC1
ATXN2
ATXN7
BAD
BRMS1L
CACNA1C
CAMK2A
CAMK2D
CAMK2G
CAPN1
CCDC187
CD27
CIMAP1B
CLEC4D
CNNM3
COIL
CRABP2
CRADD
DISC1
DLG1
DLG4
DUX1
DYNLT2B
EPS8L1
ERBIN
FAM50B
FBXL22
FXR1
GATA3
GOLGA7
GRIN1
GRIN2B
GSTT1
H4C9
HSPB1
HTR1B
ITGB3BP
KAT2B
KATNAL2
KCNA4
KCNA5
KCNN2
LDB3
LRP12
LRRC7
MAST2
MED14
MICALL2
MOS
MRPL10
MYBPC2
MYOT
MYOZ1
MYOZ2
MYOZ3
MYPN
NCAPH2
NCOA2
NCOR1
NKAPD1
NOS3
NR1I2
NRIP1
NTAQ1
PALLD
PDLIM1
PDLIM3
PKD2
PPP1CB
PPP1R9B
PSMA1
QARS1
RACK1
RAVER1
RPL35
RPP14
RTP5
SAXO1
SELE
SHANK3
SMARCA2
SNAI1
SNAPIN
SNW1
SP100
SPA17
SRP9
SSX2IP
ST7
SYNPO2
SYNPO2L
TNN
TOLLIP
TSC1
TSC2
TTN
TULP3
USP2
UTRN
ZC2HC1C
ZNF446
ZNRD2
Entrez ID
5682
88
HPRD ID
04170
00019
Ensembl ID
ENSG00000129084
ENSG00000077522
Uniprot IDs
B4E0X6
P25786
P35609
PDB IDs
4R3O
4R67
5A0Q
5GJQ
5GJR
5L4G
5LE5
5LEX
5LEY
5LEZ
5LF0
5LF1
5LF3
5LF4
5LF6
5LF7
5LN3
5M32
5T0C
5T0G
5T0H
5T0I
5T0J
5VFO
5VFP
5VFQ
5VFR
5VFS
5VFT
5VFU
6AVO
6E5B
6KWY
6MSB
6MSD
6MSE
6MSG
6MSH
6MSJ
6MSK
6R70
6REY
6RGQ
6WJD
6WJN
6XMJ
7AWE
7B12
7LXV
7NAN
7NAO
7NAP
7NAQ
7NHT
7PG9
7QXN
7QXP
7QXU
7QXW
7QXX
7QY7
7QYA
7QYB
7V5G
7V5M
7W37
7W38
7W39
7W3A
7W3B
7W3C
7W3F
7W3G
7W3H
7W3I
7W3J
7W3K
7W3M
8BZL
8CVR
8CVS
8CVT
8CXB
8JRI
8JRT
8JTI
8K0G
8QYJ
8QYL
8QYM
8QYN
8QYO
8QYS
8QZ9
8TM3
8TM4
8TM5
8TM6
8UD9
8USB
8USC
8YIX
8YIY
8YIZ
9E8G
9E8H
9E8I
9E8J
9E8K
9E8L
9E8N
9E8O
9E8Q
9HMN
1H8B
1HCI
1QUU
4D1E
5A36
5A37
5A38
5A4B
6SWT
6TS3
7A8T
7A8U
7B55
7B56
7B57
Enriched GO Terms of Interacting Partners
?
Identical Protein Binding
Protein Binding
Cytoskeleton
Intermediate Filament
Proteasome Core Complex
Keratin Filament
Intermediate Filament Organization
Structural Constituent Of Skin Epidermis
Cytoplasm
Supramolecular Fiber Organization
Intermediate Filament Cytoskeleton Organization
Intermediate Filament-based Process
Organelle Organization
Proteasome Complex
Cytosol
Protein Homooligomerization
Proteasome Core Complex, Alpha-subunit Complex
Protein Complex Oligomerization
Cytoskeleton Organization
Protein Domain Specific Binding
Aggresome Assembly
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Protein Serine/threonine Kinase Binding
Regulation Of Microtubule-based Process
Inclusion Body Assembly
Cytosine Metabolic Process
Structural Molecule Activity
Positive Regulation Of Protein K63-linked Deubiquitination
Cullin Family Protein Binding
Nucleus
Proteasome Core Complex, Beta-subunit Complex
Microtubule-based Process
Positive Regulation Of Organelle Organization
Ficolin-1-rich Granule Lumen
Regulation Of Microtubule Cytoskeleton Organization
Type III Intermediate Filament
Cellular Response To Arsenite Ion
Lung Goblet Cell Differentiation
Mitotic Spindle Astral Microtubule End
Protein Localization To Microtubule
Centrosome
Proteasomal Protein Catabolic Process
Cellular Component Assembly
Glial Cell Development
Mitotic Spindle Pole
Proteolysis Involved In Protein Catabolic Process
Pseudopodium
Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Z Disc
Muscle Alpha-actinin Binding
Actin Binding
Alpha-actinin Binding
Postsynaptic Density
Regulation Of Neuronal Synaptic Plasticity
Sarcomere Organization
Protein Binding
Actin Cytoskeleton
Actin Filament-based Process
Telethonin Binding
Organelle Organization
Cytoplasm
Neuron Projection
Actin Cytoskeleton Organization
Calmodulin Binding
Actomyosin Structure Organization
Cytoskeleton Organization
Actinin Binding
Calcium- And Calmodulin-dependent Protein Kinase Complex
FATZ Binding
Regulation Of Monoatomic Ion Transport
Positive Regulation Of Synaptic Transmission
Regulation Of Membrane Potential
Dendritic Spine
Cytoskeletal Protein Binding
Regulation Of Synaptic Plasticity
Regulation Of Transport
Intracellular Signal Transduction
Regulation Of Synaptic Transmission, Glutamatergic
Structural Constituent Of Muscle
Cell Adhesion
Nuclear Receptor Binding
Regulation Of Signaling
Regulation Of Cell Communication
Regulation Of Metal Ion Transport
Regulation Of Signal Transduction
Stress Fiber
Regulation Of Multicellular Organismal Process
Adherens Junction
Ionotropic Glutamate Receptor Signaling Pathway
Positive Regulation Of Synaptic Transmission, Glutamatergic
Positive Regulation Of Excitatory Postsynaptic Potential
Kinase Binding
Locomotor Rhythm
Cell Projection Organization
Protein-containing Complex Localization
Negative Regulation Of Calcineurin-NFAT Signaling Cascade
Regulation Of Calcium Ion Transport
Calcium-mediated Signaling
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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