RNF186

Name	ring finger protein 186
Structure	No pdb structure
Interactors	8 interactors: EPHB2 EPHB3 HIVEP1 PBX3 SCAND1 SESN2 UBE2D2 UBE2H
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Ubiquitination Protein K29-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Protein K63-linked Ubiquitination Protein Localization To Mitochondrion Apoptotic Process In Response To Mitochondrial Fragmentation Regulation Of Autophagosome Assembly
GWAS	Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Inflammatory bowel disease ( 28067908 ) Ulcerative colitis ( 19122664 20228799 23511034 28067908 )
Entrez ID	54546
HPRD ID	07885
Ensembl ID	ENSG00000178828
Uniprot IDs	Q9NXI6
PDB IDs	Not available
GO Terms Enriched among Interactors ?	Axon Guidance Receptor Activity Urogenital System Development Corpus Callosum Development Dendritic Spine Development Retinal Ganglion Cell Axon Guidance Transmembrane-ephrin Receptor Activity Axonal Fasciculation Neuron Projection Fasciculation Dendritic Spine Morphogenesis Ephrin Receptor Activity Central Nervous System Projection Neuron Axonogenesis Dendritic Spine Organization Central Nervous System Neuron Axonogenesis Ubiquitin Conjugating Enzyme Activity Neuron Projection Organization Postsynapse Organization Neuron Recognition Ephrin Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Polyubiquitination Protein Modification Process Positive Regulation Of Synapse Assembly Posterior Compartment Specification Anterior Compartment Pattern Formation Roof Of Mouth Development Neuron Projection Retraction Negative Regulation Of Glutamate Receptor Signaling Pathway Sulfiredoxin Activity Positive Regulation Of Cell Junction Assembly Protein K48-linked Ubiquitination Vesicle-mediated Intercellular Transport Cell Recognition Negative Regulation Of Translation In Response To Endoplasmic Reticulum Stress Protein Tyrosine Kinase Activity Regulation Of Axonogenesis Compartment Pattern Specification ATP Binding Optic Nerve Morphogenesis Hindbrain Tangential Cell Migration Axonogenesis Dorsal Spinal Cord Development Protein Ubiquitination Positive Regulation Of Lipophagy Regulation Of Synapse Assembly Enzyme-linked Receptor Protein Signaling Pathway Oxidoreductase Activity, Acting On Peroxide As Acceptor Protein Modification By Small Protein Conjugation Postsynaptic Membrane Assembly L-leucine Binding Atg1/ULK1 Kinase Complex