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UBE2D3 and ITCH
Number of citations of the paper that reports this interaction (PubMedID
30017913
)
69
Data Source:
BioGRID
(pull down)
UBE2D3
ITCH
Description
ubiquitin conjugating enzyme E2 D3
itchy E3 ubiquitin protein ligase
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Endosome
Cytosol
Plasma Membrane
Endosome Membrane
Membrane
Extracellular Exosome
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Endosome
Early Endosome
Cytosol
Plasma Membrane
Cell Cortex
Endosome Membrane
Membrane
Cytoplasmic Vesicle
Early Endosome Membrane
Protein-containing Complex
Extracellular Exosome
Cell Periphery
Molecular Function
Nucleotide Binding
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Transferase Activity
Ubiquitin Protein Ligase Activity
Ubiquitin Conjugating Enzyme Activity
Ubiquitin-protein Transferase Activity
Protein Binding
Transferase Activity
Ligase Activity
Ubiquitin-like Protein Transferase Activity
Ubiquitin-ubiquitin Ligase Activity
Ribonucleoprotein Complex Binding
Ubiquitin-like Protein Ligase Binding
CXCR Chemokine Receptor Binding
Ubiquitin Protein Ligase Activity
Arrestin Family Protein Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Protein Polyubiquitination
DNA Repair
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
Apoptotic Process
DNA Damage Response
Protein Ubiquitination
Negative Regulation Of BMP Signaling Pathway
Protein Modification Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Protein Autoubiquitination
Protein K48-linked Ubiquitination
Protein K11-linked Ubiquitination
Protein K6-linked Ubiquitination
Positive Regulation Of Protein Targeting To Mitochondrion
Protein Polyubiquitination
Regulation Of Cell Growth
Immune System Process
Positive Regulation Of T Cell Anergy
Negative Regulation Of Immune System Process
Positive Regulation Of Immune System Process
Cytoplasmic Pattern Recognition Receptor Signaling Pathway
T Cell Anergy
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
Apoptotic Process
Inflammatory Response
Response To Oxidative Stress
Positive Regulation Of Catabolic Process
Regulation Of Gene Expression
Positive Regulation Of Macromolecule Metabolic Process
Protein Ubiquitination
Protein Catabolic Process
Receptor Internalization
Negative Regulation Of Type I Interferon Production
Protein K29-linked Ubiquitination
CD4-positive, Alpha-beta T Cell Proliferation
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
CXCL12-activated CXCR4 Signaling Pathway
Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway
Negative Regulation Of Apoptotic Process
Negative Regulation Of Canonical NF-kappaB Signal Transduction
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Innate Immune Response
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of JNK Cascade
Symbiont Entry Into Host Cell
Negative Regulation Of Defense Response To Virus
Negative Regulation Of Multicellular Organismal Process
Defense Response To Virus
Protein Autoubiquitination
Regulation Of Necroptotic Process
Protein K63-linked Ubiquitination
Protein K48-linked Ubiquitination
Regulation Of Protein Deubiquitination
Protein Branched Polyubiquitination
Regulation Of Hematopoietic Stem Cell Differentiation
Negative Regulation Of Intracellular Signal Transduction
Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation
Positive Regulation Of Receptor Catabolic Process
Pathways
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
TICAM1, RIP1-mediated IKK complex recruitment
Signaling by BMP
Downregulation of SMAD2/3:SMAD4 transcriptional activity
PINK1-PRKN Mediated Mitophagy
Regulation of TNFR1 signaling
E3 ubiquitin ligases ubiquitinate target proteins
Neddylation
Peroxisomal protein import
Negative regulators of DDX58/IFIH1 signaling
IKK complex recruitment mediated by RIP1
Inactivation of CSF3 (G-CSF) signaling
Antigen processing: Ubiquitination & Proteasome degradation
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Downregulation of ERBB4 signaling
NOD1/2 Signaling Pathway
Activated NOTCH1 Transmits Signal to the Nucleus
Activated NOTCH1 Transmits Signal to the Nucleus
Degradation of GLI1 by the proteasome
Hedgehog 'on' state
Regulation of necroptotic cell death
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Negative regulators of DDX58/IFIH1 signaling
SARS-CoV-1 activates/modulates innate immune responses
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Alanine aminotransferase levels (
33547301
)
Asthma and attention deficit hyperactivity disorder (
31619474
)
Diastolic blood pressure (
30224653
)
Shoulder impingement or rotator cuff tear (
33482370
)
Appendicular lean mass (
33097823
)
Bipolar disorder (
31043756
)
Colorectal cancer or advanced adenoma (
30510241
)
Estimated glomerular filtration rate (
31015462
31152163
)
Fish- and plant-related diet (
32066663
)
Heel bone mineral density (
28869591
)
Hip circumference adjusted for BMI (
34021172
)
Oily fish consumption (
32066663
)
Pork consumption (
32066663
)
Vitiligo (
27723757
)
Interacting Genes
223 interacting genes:
AMBRA1
AMFR
ANAPC11
AREL1
ARIH1
ARIH2
ARK2C
ATXN3
BARD1
BFAR
BIRC2
BIRC3
BIRC7
BIRC8
BMI1
BRCA1
CADPS2
CBL
CBLC
CHFR
CNOT4
CRBN
CSNK2A1
CUL2
CUL4B
DBN1
DCAF1
DCUN1D1
DTX1
DTX2
DTX3
DTX3L
DZIP3
EPS15
F12
FBXL12
FBXL2
FBXO2
FBXO25
FBXO4
FBXO7
FBXW10
FBXW11
FBXW8
FOCAD
FZR1
H2AC4
HDAC6
HECTD1
HECTD3
HECW1
HECW2
HERC1
HERC2
HSP90AB1
HSPA1A
IKBKG
ITCH
KAT2B
KDM1B
KLHL3
LRSAM1
MAEA
MAP3K1
MAPT
MARCHF3
MARCHF5
MARCHF7
MARCHF8
MDM2
MDM4
MEX3B
MEX3C
MGRN1
MIB1
MID1
MID2
MKRN1
MKRN3
MSL1
MSL2
MUL1
MYCBP2
MYLIP
NBR1
NEDD4
NEDD4L
NFKB1
NFKBIA
NHLRC1
NOSIP
OTUB1
PCGF1
PCGF2
PCGF3
PCGF5
PCGF6
PCNA
PDCD5
PELI1
PJA1
PJA2
POLL
POLM
PPP4C
PRPF19
RABGEF1
RBCK1
RBX1
RCHY1
RELA
RFFL
RFWD3
RIGI
RING1
RLIM
RMND5B
RNF103
RNF111
RNF113A
RNF114
RNF115
RNF122
RNF125
RNF126
RNF13
RNF130
RNF14
RNF150
RNF166
RNF167
RNF168
RNF181
RNF185
RNF19B
RNF2
RNF213
RNF216
RNF220
RNF26
RNF31
RNF34
RNF38
RNF4
RNF41
RNF43
RNF5
RNF8
RNFT1
RPLP1
RSPRY1
SAT1
SH3RF1
SIAH1
SIAH2
SMURF1
SMURF2
STAM2
STAU1
STK25
STUB1
SYVN1
TMEM129
TOPORS
TRAF6
TRAIP
TRIM10
TRIM13
TRIM17
TRIM2
TRIM21
TRIM23
TRIM25
TRIM26
TRIM27
TRIM28
TRIM3
TRIM31
TRIM32
TRIM33
TRIM35
TRIM37
TRIM38
TRIM39
TRIM43
TRIM45
TRIM5
TRIM50
TRIM54
TRIM55
TRIM58
TRIM62
TRIM63
TRIM68
TRIM69
TRIM7
TRIM8
TUBA1A
UBA1
UBA6
UBASH3B
UBC
UBE2O
UBE3A
UBE3C
UBE4A
UBE4B
UBOX5
UBR5
UFM1
UHRF1
USP7
UVSSA
VHL
WSB1
WWP1
WWP2
XIAP
XPNPEP1
ZNF598
ZNRF1
ZNRF2
ZNRF4
132 interacting genes:
AGO2
AKT1
ARHGEF7
ARID1A
ARRB2
ARRDC3
ATN1
BECN1
BIN1
BRAF
CBL
CBLC
CDC34
CPSF6
CPSF7
CSNK2A1
CXCR4
CYLD
DAZAP1
DSCR9
DTX1
DTX3L
ERBB4
ESS2
EWSR1
FYN
GJA1
GLIS3
GNAI2
H1-2
HNRNPUL1
JUN
JUNB
KIAA1210
KPNB1
KSR1
LAPTM5
LITAF
LRRK1
MAP2
MAP2K1
MAP2K4
MAP3K2
MAPK8
MLANA
MLKL
MYCT1
N4BP1
NDFIP1
NDFIP2
NEDD9
NFE2
NOTCH1
NRAS
NUDT21
NUMB
PABPC1
PACSIN1
PIP4P2
POLR2A
POLR2B
POLR2C
POLR2E
POU5F1
PRKACA
PRRG4
RAF1
RBM14
REPS2
RHBDD1
RIPK1
RNF11
RORA
RPAP2
RPAP3
SCNN1A
SCNN1B
SF1
SGK3
SH3GL1
SH3GL2
SIK1
SMAD2
SMAD3
SMARCC1
SMARCC2
SMARCE1
SMN1
SNX9
SPART
SPEN
STAM2
STRIP2
SUFU
TAB1
TAF15
TGFB1I1
TMEM51
TP73
TRERF1
TRPC4
TRPV1
TRPV4
TTYH3
UBAP2
UBAP2L
UBC
UBE2C
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2G1
UBE2J2
UBE2K
UBE2L3
UBE2L6
UBE2M
UBE2O
UBE2Q1
UBE2Q2
UBE2R2
URI1
UVRAG
WASL
WBP2
YWHAQ
YY1
ZC3H14
Entrez ID
7323
83737
HPRD ID
04269
07565
Ensembl ID
ENSG00000109332
ENSG00000078747
Uniprot IDs
D6RAH7
P61077
Q96J02
PDB IDs
1X23
2FUH
3L1Z
3RPG
3UGB
4BVU
4R8P
4S3O
5EGG
5IFR
6CP0
6T7F
7JZV
7LYB
8AMS
8GRQ
8SMW
8SMX
8SMY
8SMZ
8SN0
8SN1
8SN2
8SN3
8SN4
8SN5
8SN6
8SN7
8SN8
8SN9
8SNA
8U14
8UPF
8UQ8
8UQ9
8UQA
8UQB
8UQC
8UQD
8UQE
8X7I
8X7J
8X7K
9IPU
2DMV
2KYK
2NQ3
2P4R
2YSF
3TUG
4ROF
5C7M
5CQ2
5DWS
5DZD
5SXP
Enriched GO Terms of Interacting Partners
?
Ubiquitin Protein Ligase Activity
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Post-translational Protein Modification
Ubiquitin-protein Transferase Activity
Protein Modification Process
Protein Polyubiquitination
Modification-dependent Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Proteolysis Involved In Protein Catabolic Process
Transferase Activity
Protein Metabolic Process
Macromolecule Catabolic Process
Zinc Ion Binding
Proteolysis
Macromolecule Metabolic Process
Catabolic Process
Metal Ion Binding
Proteasomal Protein Catabolic Process
Protein Catabolic Process
Protein Autoubiquitination
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Protein K48-linked Ubiquitination
Protein K63-linked Ubiquitination
Ubiquitin Ligase Complex
Cytoplasm
Response To Stress
Cellular Response To Stress
Protein Monoubiquitination
Regulation Of Signal Transduction
Ubiquitin-ubiquitin Ligase Activity
Regulation Of Signaling
Regulation Of Post-translational Protein Modification
Regulation Of Cell Communication
Ubiquitin Protein Ligase Binding
Positive Regulation Of Catabolic Process
Ubiquitin Binding
Cytosol
Regulation Of Protein Ubiquitination
Positive Regulation Of Protein Metabolic Process
Suppression Of Viral Release By Host
Innate Immune Response
Positive Regulation Of Post-translational Protein Modification
Regulation Of Intracellular Signal Transduction
Negative Regulation Of Signal Transduction
DNA Damage Response
Positive Regulation Of Protein Ubiquitination
Regulation Of Protein Catabolic Process
Immune System Process
Negative Regulation Of Signaling
Ubiquitin Conjugating Enzyme Activity
Ubiquitin-protein Transferase Activity
Protein Polyubiquitination
Protein K48-linked Ubiquitination
Protein Ubiquitination
Post-translational Protein Modification
Protein Modification By Small Protein Conjugation
Modification-dependent Protein Catabolic Process
Ubiquitin Protein Ligase Binding
Nucleus
Cytosol
Ubiquitin-dependent Protein Catabolic Process
Macromolecule Catabolic Process
Proteolysis Involved In Protein Catabolic Process
ATP Binding
Transferase Activity
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Metabolic Process
Nucleoplasm
Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Metabolic Process
Protein Modification Process
Positive Regulation Of Macromolecule Metabolic Process
Nucleotide Binding
WW Domain Binding
Regulation Of Primary Metabolic Process
Protein Binding
Intracellular Signal Transduction
Regulation Of RNA Metabolic Process
Positive Regulation Of Signal Transduction
Regulation Of Protein Modification Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Intracellular Signaling Cassette
Cytoplasm
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Biosynthetic Process
Regulation Of Cell Differentiation
Macromolecule Metabolic Process
Positive Regulation Of RNA Metabolic Process
Protein K11-linked Ubiquitination
Regulation Of Protein Metabolic Process
Positive Regulation Of Protein Modification Process
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Regulation Of Protein Ubiquitination
Negative Regulation Of Metabolic Process
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Tagcloud (Intersection)
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