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UBE2D3 and MARCH5
Number of citations of the paper that reports this interaction (PMID
19741096
)
11
Data Source:
BioGRID
(pull down)
UBE2D3
MARCH5
Gene Name
ubiquitin-conjugating enzyme E2D 3
membrane-associated ring finger (C3HC4) 5
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleoplasm
Cytosol
Plasma Membrane
Endosome Membrane
Extracellular Vesicular Exosome
Mitochondrial Outer Membrane
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Membrane
Integral Component Of Membrane
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Ligase Activity
Ubiquitin Conjugating Enzyme Activity
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Ligase Activity
GTPase Binding
Biological Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Protein Polyubiquitination
Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
DNA Repair
Transcription, DNA-templated
Transcription Initiation From RNA Polymerase II Promoter
Cellular Protein Modification Process
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
Apoptotic Process
Transforming Growth Factor Beta Receptor Signaling Pathway
Gene Expression
Protein Ubiquitination
BMP Signaling Pathway
Negative Regulation Of Type I Interferon Production
Toll-like Receptor 3 Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Innate Immune Response
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Protein K48-linked Ubiquitination
Protein K11-linked Ubiquitination
Cellular Response To Hypoxia
Protein Polyubiquitination
Protein Autoubiquitination
Protein Localization To Mitochondrion
Regulation Of Mitochondrial Fission
Positive Regulation Of Mitochondrial Fission
Negative Regulation Of Cell Aging
Pathways
Loss of Function of TGFBR2 in Cancer
Cellular response to hypoxia
Antigen processing: Ubiquitination & Proteasome degradation
Regulation of Hypoxia-inducible Factor (HIF) by oxygen
Negative regulators of RIG-I/MDA5 signaling
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
SMAD2/3 MH2 Domain Mutants in Cancer
TGFBR1 LBD Mutants in Cancer
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Signaling by BMP
Activated TLR4 signalling
Generic Transcription Pathway
Class I MHC mediated antigen processing & presentation
Innate Immune System
TGFBR2 MSI Frameshift Mutants in Cancer
SMAD2/3 Phosphorylation Motif Mutants in Cancer
Loss of Function of SMAD2/3 in Cancer
TRIF-mediated TLR3/TLR4 signaling
IKK complex recruitment mediated by RIP1
TGFBR2 Kinase Domain Mutants in Cancer
Loss of Function of SMAD4 in Cancer
TGFBR1 KD Mutants in Cancer
MyD88-independent cascade
Loss of Function of TGFBR1 in Cancer
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
Toll-Like Receptors Cascades
Signaling by TGF-beta Receptor Complex in Cancer
Signaling by TGF-beta Receptor Complex
Toll Like Receptor 4 (TLR4) Cascade
Toll Like Receptor 3 (TLR3) Cascade
SMAD4 MH2 Domain Mutants in Cancer
Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions
180 interactors:
AMBRA1
AMFR
ARIH1
ARIH2
BARD1
BFAR
BIRC2
BIRC3
BIRC7
BIRC8
BMI1
BRCA1
BTRC
CADPS2
CBL
CBLC
CHFR
CNOT4
CREB3L1
CREB3L2
CUL3
DBN1
DDX58
DTX1
DTX2
DTX3
DTX3L
DZIP3
EPS15
F12
FBXL2
FBXO2
FBXO25
FBXO32
FBXW11
FBXW8
FOCAD
FZR1
HDAC6
HERC1
HERC2
HUWE1
IKBKG
ITCH
KAT2B
KIAA1107
LRSAM1
MAP3K1
MARCH3
MARCH5
MARCH7
MARCH8
MDM2
MDM4
MEX3B
MGRN1
MIB1
MID1
MKRN1
MKRN3
MSL1
MSL2
MUL1
MYLIP
NEDD4
NEDD4L
NFKB1
NFKBIA
NHLRC1
OTUB1
PARK2
PCNA
PDCD5
PJA1
PJA2
POLL
POLM
PRPF19
RABGEF1
RBCK1
RBX1
RELA
RFFL
RFWD3
RING1
RLIM
RMND5B
RNF10
RNF103
RNF11
RNF111
RNF114
RNF115
RNF122
RNF125
RNF126
RNF13
RNF130
RNF14
RNF150
RNF165
RNF166
RNF167
RNF168
RNF181
RNF185
RNF2
RNF220
RNF25
RNF26
RNF31
RNF38
RNF4
RNF41
RNF43
RNF5
RNF8
RPLP1
RSPRY1
SAT1
SH3RF1
SHARPIN
SIAH1
SIAH2
SKP1
SMURF1
SMURF2
STAM2
STAU1
STK25
STUB1
SYVN1
TOPORS
TRAF6
TRAIP
TRIM10
TRIM17
TRIM2
TRIM23
TRIM25
TRIM26
TRIM27
TRIM28
TRIM31
TRIM32
TRIM33
TRIM35
TRIM37
TRIM38
TRIM39
TRIM43
TRIM45
TRIM5
TRIM50
TRIM54
TRIM55
TRIM58
TRIM63
TRIM68
TRIM7
TRIM8
TUBA1A
UBA1
UBA6
UBASH3B
UBC
UBE3A
UBE4A
UBE4B
UBOX5
UBR5
UFM1
UHRF2
WSB1
WWP2
XIAP
XPNPEP1
ZNRF1
ZNRF2
ZNRF4
17 interactors:
AKTIP
FATE1
FIS1
MAP1B
MFN2
SOD1
TANK
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2E3
UBE2I
UBE2N
UBE2T
UBE2W
UTRN
Entrez ID
7323
54708
HPRD ID
04269
07909
Ensembl ID
ENSG00000109332
ENSG00000198060
Uniprot IDs
D6RAH7
P61077
B4DGV8
Q9NX47
PDB IDs
1X23
2FUH
3L1Z
3RPG
3UGB
Enriched GO Terms of Interacting Partners
?
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Cellular Protein Modification Process
Protein Polyubiquitination
Cellular Protein Metabolic Process
Protein Metabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Protein Catabolic Process
Cellular Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Cellular Macromolecule Catabolic Process
Protein Autoubiquitination
Cellular Metabolic Process
Proteolysis
Catabolic Process
Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Protein K63-linked Ubiquitination
Protein Monoubiquitination
Metabolic Process
Protein K48-linked Ubiquitination
Regulation Of Signal Transduction
Regulation Of Protein Ubiquitination
Regulation Of Signaling
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Cellular Response To Stress
Cellular Response To Stimulus
Negative Regulation Of Cellular Metabolic Process
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Cellular Process
Positive Regulation Of NF-kappaB Transcription Factor Activity
Regulation Of Protein Metabolic Process
Regulation Of Viral Release From Host Cell
Negative Regulation Of Viral Release From Host Cell
Positive Regulation Of Protein Ubiquitination
Response To Stress
Negative Regulation Of Signal Transduction
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Apoptotic Process
Negative Regulation Of Signaling
Response To Stimulus
Histone Ubiquitination
Regulation Of Cellular Protein Metabolic Process
Programmed Cell Death
Cell Death
Death
Regulation Of Intracellular Signal Transduction
Protein Polyubiquitination
Protein K48-linked Ubiquitination
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Protein K11-linked Ubiquitination
Toll-like Receptor 4 Signaling Pathway
Toll-like Receptor Signaling Pathway
Protein Monoubiquitination
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Activation Of Innate Immune Response
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Protein Catabolic Process
TRIF-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Positive Regulation Of Innate Immune Response
Regulation Of Innate Immune Response
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Catabolic Process
Proteasomal Protein Catabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Cellular Macromolecule Catabolic Process
Protein K63-linked Ubiquitination
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Regulation Of DNA-templated Transcription In Response To Stress
Cellular Protein Modification Process
Immune Response-regulating Signaling Pathway
Positive Regulation Of Ubiquitin-protein Transferase Activity
Positive Regulation Of Ligase Activity
Positive Regulation Of Transferase Activity
Regulation Of Ubiquitin-protein Transferase Activity
Cellular Response To Stress
Proteolysis
Cellular Response To Hypoxia
Cellular Response To Decreased Oxygen Levels
Positive Regulation Of Immune Response
Cellular Response To Oxygen Levels
Positive Regulation Of Cellular Protein Metabolic Process
Mitochondrial Fusion
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Protein Ubiquitination
Cellular Protein Metabolic Process
Response To Stress
Regulation Of Immune System Process
Innate Immune Response
Regulation Of Immune Response
Tagcloud
?
2h5
accompanies
anova
dynactin
gadd45a
gtf2h5
invites
keuls
macaques
malfunctioning
nbn1
ndd
ndds
newman
ovx
perimenopausal
presenilin1
proteosome
psen1
rad23a
raphe
scna
serotonin
speculation
subserving
symptomology
ube3a
ubea5
ubiquinase
Tagcloud (Difference)
?
2h5
accompanies
anova
dynactin
gadd45a
gtf2h5
invites
keuls
macaques
malfunctioning
nbn1
ndd
ndds
newman
ovx
perimenopausal
presenilin1
proteosome
psen1
rad23a
raphe
scna
serotonin
speculation
subserving
symptomology
ube3a
ubea5
ubiquinase
Tagcloud (Intersection)
?