UBE2D3 and HSP90AB1

Number of citations: 36 (PubMedID 32401531)
Data Source: BioGRID (enzymatic study)

		UBE2D3	HSP90AB1
Name		ubiquitin conjugating enzyme E2 D3	heat shock protein 90 alpha family class B member 1
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Endosome Cytosol Plasma Membrane Endosome Membrane Membrane Extracellular Exosome	Extracellular Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane COP9 Signalosome Cell Surface Membrane Protein-containing Complex Aryl Hydrocarbon Receptor Complex Secretory Granule Lumen Melanosome Neuronal Cell Body Dendritic Growth Cone Axonal Growth Cone Perinuclear Region Of Cytoplasm Extracellular Exosome Protein Folding Chaperone Complex Dynein Axonemal Particle Ficolin-1-rich Granule Lumen HSP90-CDC37 Chaperone Complex
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity	Nucleotide Binding RNA Binding Double-stranded RNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity Protein Kinase Regulator Activity Kinase Binding Protein Kinase Binding MHC Class II Protein Complex Binding Nitric-oxide Synthase Regulator Activity TPR Domain Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Peptide Binding Identical Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding ATP-dependent Protein Binding Protein Folding Chaperone Cadherin Binding Protein Dimerization Activity Tau Protein Binding Unfolded Protein Binding DNA Polymerase Binding Protein Phosphatase Activator Activity Disordered Domain Specific Binding ATP-dependent Protein Folding Chaperone Receptor Ligand Inhibitor Activity Histone Methyltransferase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination DNA Repair Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Apoptotic Process DNA Damage Response Protein Ubiquitination Negative Regulation Of BMP Signaling Pathway Protein Modification Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein K6-linked Ubiquitination Positive Regulation Of Protein Targeting To Mitochondrion	Placenta Development Protein Folding Response To Unfolded Protein Telomere Maintenance Via Telomerase Virion Attachment To Host Cell Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Localization Cellular Response To Heat Negative Regulation Of Apoptotic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Cell Differentiation Protein Stabilization Chaperone-mediated Protein Complex Assembly Regulation Of Cell Cycle Cellular Response To Interleukin-4 Supramolecular Fiber Organization Negative Regulation Of Proteasomal Protein Catabolic Process Telomerase Holoenzyme Complex Assembly Positive Regulation Of Protein Localization To Cell Surface
Pathways		Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha TICAM1, RIP1-mediated IKK complex recruitment Signaling by BMP Downregulation of SMAD2/3:SMAD4 transcriptional activity PINK1-PRKN Mediated Mitophagy Regulation of TNFR1 signaling E3 ubiquitin ligases ubiquitinate target proteins Neddylation Peroxisomal protein import Negative regulators of DDX58/IFIH1 signaling IKK complex recruitment mediated by RIP1 Inactivation of CSF3 (G-CSF) signaling Antigen processing: Ubiquitination & Proteasome degradation ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	DDX58/IFIH1-mediated induction of interferon-alpha/beta Regulation of actin dynamics for phagocytic cup formation HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand HSF1 activation Attenuation phase HSF1-dependent transactivation Sema3A PAK dependent Axon repulsion Uptake and function of diphtheria toxin Neutrophil degranulation The NLRP3 inflammasome The role of GTSE1 in G2/M progression after G2 checkpoint Aryl hydrocarbon receptor signalling ESR-mediated signaling RHOBTB2 GTPase cycle Estrogen-dependent gene expression Chaperone Mediated Autophagy Purinergic signaling in leishmaniasis infection Potential therapeutics for SARS SARS-CoV-2 activates/modulates innate and adaptive immune responses Assembly and release of respiratory syncytial virus (RSV) virions Respiratory syncytial virus genome replication
Drugs		None	Geldanamycin 9-Butyl-8-(3,4,5-Trimethoxybenzyl)-9h-Purin-6-Amine Radicicol Tanespimycin SNX-5422 CCT-018159 8-(6-BROMO-BENZO[1,3]DIOXOL-5-YLSULFANYL)-9-(3-ISOPROPYLAMINO-PROPYL)-ADENINE 4-{4-[4-(3-AMINOPROPOXY)PHENYL]-1H-PYRAZOL-5-YL}-6-CHLOROBENZENE-1,3-DIOL (5E)-14-CHLORO-15,17-DIHYDROXY-4,7,8,9,10,11-HEXAHYDRO-2-BENZOXACYCLOPENTADECINE-1,12(3H,13H)-DIONE (5Z)-12-CHLORO-13,15-DIHYDROXY-4,7,8,9-TETRAHYDRO-2-BENZOXACYCLOTRIDECINE-1,10(3H,11H)-DIONE (5E)-12-CHLORO-13,15-DIHYDROXY-4,7,8,9-TETRAHYDRO-2-BENZOXACYCLOTRIDECINE-1,10(3H,11H)-DIONE (5Z)-13-CHLORO-14,16-DIHYDROXY-3,4,7,8,9,10-HEXAHYDRO-1H-2-BENZOXACYCLOTETRADECINE-1,11(12H)-DIONE METHYL 3-CHLORO-2-{3-[(2,5-DIHYDROXY-4-METHOXYPHENYL)AMINO]-3-OXOPROPYL}-4,6-DIHYDROXYBENZOATE 2-(3-AMINO-2,5,6-TRIMETHOXYPHENYL)ETHYL 5-CHLORO-2,4-DIHYDROXYBENZOATE Polaprezinc
GWAS		Alanine aminotransferase levels ( 33547301 ) Asthma and attention deficit hyperactivity disorder ( 31619474 ) Diastolic blood pressure ( 30224653 ) Shoulder impingement or rotator cuff tear ( 33482370 )	Mean corpuscular volume ( 32888494 ) Mean reticulocyte volume ( 32888494 ) Red blood cell count ( 32888494 ) Reticulocyte count ( 32888494 ) Waist-to-hip ratio adjusted for BMI ( 26426971 ) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )
Interacting Genes		223 interacting genes: AMBRA1 AMFR ANAPC11 AREL1 ARIH1 ARIH2 ARK2C ATXN3 BARD1 BFAR BIRC2 BIRC3 BIRC7 BIRC8 BMI1 BRCA1 CADPS2 CBL CBLC CHFR CNOT4 CRBN CSNK2A1 CUL2 CUL4B DBN1 DCAF1 DCUN1D1 DTX1 DTX2 DTX3 DTX3L DZIP3 EPS15 F12 FBXL12 FBXL2 FBXO2 FBXO25 FBXO4 FBXO7 FBXW10 FBXW11 FBXW8 FOCAD FZR1 H2AC4 HDAC6 HECTD1 HECTD3 HECW1 HECW2 HERC1 HERC2 HSP90AB1 HSPA1A IKBKG ITCH KAT2B KDM1B KLHL3 LRSAM1 MAEA MAP3K1 MAPT MARCHF3 MARCHF5 MARCHF7 MARCHF8 MDM2 MDM4 MEX3B MEX3C MGRN1 MIB1 MID1 MID2 MKRN1 MKRN3 MSL1 MSL2 MUL1 MYCBP2 MYLIP NBR1 NEDD4 NEDD4L NFKB1 NFKBIA NHLRC1 NOSIP OTUB1 PCGF1 PCGF2 PCGF3 PCGF5 PCGF6 PCNA PDCD5 PELI1 PJA1 PJA2 POLL POLM PPP4C PRPF19 RABGEF1 RBCK1 RBX1 RCHY1 RELA RFFL RFWD3 RIGI RING1 RLIM RMND5B RNF103 RNF111 RNF113A RNF114 RNF115 RNF122 RNF125 RNF126 RNF13 RNF130 RNF14 RNF150 RNF166 RNF167 RNF168 RNF181 RNF185 RNF19B RNF2 RNF213 RNF216 RNF220 RNF26 RNF31 RNF34 RNF38 RNF4 RNF41 RNF43 RNF5 RNF8 RNFT1 RPLP1 RSPRY1 SAT1 SH3RF1 SIAH1 SIAH2 SMURF1 SMURF2 STAM2 STAU1 STK25 STUB1 SYVN1 TMEM129 TOPORS TRAF6 TRAIP TRIM10 TRIM13 TRIM17 TRIM2 TRIM21 TRIM23 TRIM25 TRIM26 TRIM27 TRIM28 TRIM3 TRIM31 TRIM32 TRIM33 TRIM35 TRIM37 TRIM38 TRIM39 TRIM43 TRIM45 TRIM5 TRIM50 TRIM54 TRIM55 TRIM58 TRIM62 TRIM63 TRIM68 TRIM69 TRIM7 TRIM8 TUBA1A UBA1 UBA6 UBASH3B UBC UBE2O UBE3A UBE3C UBE4A UBE4B UBOX5 UBR5 UFM1 UHRF1 USP7 UVSSA VHL WSB1 WWP1 WWP2 XIAP XPNPEP1 ZNF598 ZNRF1 ZNRF2 ZNRF4	68 interacting genes: ACD AKT1 ANXA1 ARHGAP1 BTG3 CCT2 CDC37L1 CDK4 CDKN2A CHORDC1 CHUK CLIC4 CSNK2A1 CYP17A1 DDX24 EGFR ENO1 ERBB2 ESR1 ESRRB FCHSD2 GSK3A GSK3B HSPB1 IKBKB IKBKE IKBKG ITGB1BP2 KEAP1 MAP3K14 MAP3K3 MAPK6 MKNK1 MYCBP2 NR2C2 NR3C1 NR4A1 OGT PGR POT1 PPID PTP4A2 RAF1 RHOBTB2 SERPINB5 SGTA SHKBP1 SIRPA SLC34A1 STARD13 STAT1 STAT3 SUMO2 TAF1D TBK1 TERF1 TINF2 TNNT1 TP53 TSSK6 UBE2D3 UBE3A UNC45A USP50 WASL WEE2-AS1 XIAP YWHAB
Entrez ID		7323	3326
HPRD ID		04269	06763
Ensembl ID		ENSG00000109332	ENSG00000096384
Uniprot IDs		D6RAH7 P61077	B4DGL0 P08238 Q6PK50
PDB IDs		1X23 2FUH 3L1Z 3RPG 3UGB 4BVU 4R8P 4S3O 5EGG 5IFR 6CP0 6T7F 7JZV 7LYB 8AMS 8GRQ 8SMW 8SMX 8SMY 8SMZ 8SN0 8SN1 8SN2 8SN3 8SN4 8SN5 8SN6 8SN7 8SN8 8SN9 8SNA 8U14 8UPF 8UQ8 8UQ9 8UQA 8UQB 8UQC 8UQD 8UQE 8X7I 8X7J 8X7K 9IPU	1QZ2 1UYM 2L6J 3FWV 3NMQ 3PRY 3UQ3 5FWK 5FWL 5FWM 5FWP 5UC4 5UCH 5UCI 5UCJ 6N8W 6N8Y 7ULJ 7Z37 7Z38 7ZR0 7ZR5 7ZR6 7ZUB 8EOA 8EOB 8GAE 8GFT 8QMO
GO Terms Enriched among Interactors		Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Modification Process Protein Polyubiquitination Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Transferase Activity Protein Metabolic Process Macromolecule Catabolic Process Zinc Ion Binding Proteolysis Macromolecule Metabolic Process Catabolic Process Metal Ion Binding Proteasomal Protein Catabolic Process Protein Catabolic Process Protein Autoubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Protein K63-linked Ubiquitination Ubiquitin Ligase Complex Cytoplasm Response To Stress Cellular Response To Stress Protein Monoubiquitination Regulation Of Signal Transduction Ubiquitin-ubiquitin Ligase Activity Regulation Of Signaling Regulation Of Post-translational Protein Modification Regulation Of Cell Communication Ubiquitin Protein Ligase Binding Positive Regulation Of Catabolic Process Ubiquitin Binding Cytosol Regulation Of Protein Ubiquitination Positive Regulation Of Protein Metabolic Process Suppression Of Viral Release By Host Innate Immune Response Positive Regulation Of Post-translational Protein Modification Regulation Of Intracellular Signal Transduction Negative Regulation Of Signal Transduction DNA Damage Response Positive Regulation Of Protein Ubiquitination Regulation Of Protein Catabolic Process Immune System Process Negative Regulation Of Signaling	Positive Regulation Of Macromolecule Metabolic Process Intracellular Signal Transduction Positive Regulation Of Metabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein Kinase Activity Intracellular Signaling Cassette Cytosol Positive Regulation Of Macromolecule Biosynthetic Process Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Metabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Intracellular Receptor Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Regulation Of Intracellular Signal Transduction Identical Protein Binding Kinase Activity Nuclear Receptor Activity Negative Regulation Of Macromolecule Metabolic Process Shelterin Complex Protein Serine Kinase Activity Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Proteolysis Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Signal Transduction Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Telomere Maintenance Via Telomerase Nuclear Telomere Cap Complex Positive Regulation Of RNA Metabolic Process Positive Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process IkappaB Kinase Activity Nucleus Estrogen Response Element Binding Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Catabolic Process Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Protein Metabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling