UBE2D3 and UHRF1

Number of citations of the paper that reports this interaction (PubMedID 36734974)
74

Data Source:
BioGRID (pull down)

		UBE2D3	UHRF1
Description		ubiquitin conjugating enzyme E2 D3	ubiquitin like with PHD and ring finger domains 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Endosome Cytosol Plasma Membrane Endosome Membrane Membrane Extracellular Exosome	Chromatin Euchromatin Heterochromatin Nucleus Nucleoplasm Replication Fork Spindle Nuclear Matrix
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity	Cis-regulatory Region Sequence-specific DNA Binding Nucleic Acid Binding DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Methyl-CpG Binding Transferase Activity Histone Binding Identical Protein Binding Hemi-methylated DNA-binding Metal Ion Binding Ubiquitin Protein Ligase Activity Histone H3K9me2/3 Reader Activity DNA Damage Sensor Activity Histone H3 Ubiquitin Ligase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination DNA Repair Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Apoptotic Process DNA Damage Response Protein Ubiquitination Negative Regulation Of BMP Signaling Pathway Protein Modification Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein K6-linked Ubiquitination Positive Regulation Of Protein Targeting To Mitochondrion	Negative Regulation Of Transcription By RNA Polymerase II Double-strand Break Repair Via Homologous Recombination DNA Repair Chromatin Organization Ubiquitin-dependent Protein Catabolic Process Response To Stress DNA Damage Response Protein Ubiquitination Heterochromatin Formation Homologous Recombination Epigenetic Regulation Of Gene Expression Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Metabolic Process Protein Autoubiquitination Mitotic Spindle Assembly
Pathways		Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha TICAM1, RIP1-mediated IKK complex recruitment Signaling by BMP Downregulation of SMAD2/3:SMAD4 transcriptional activity PINK1-PRKN Mediated Mitophagy Regulation of TNFR1 signaling E3 ubiquitin ligases ubiquitinate target proteins Neddylation Peroxisomal protein import Negative regulators of DDX58/IFIH1 signaling IKK complex recruitment mediated by RIP1 Inactivation of CSF3 (G-CSF) signaling Antigen processing: Ubiquitination & Proteasome degradation ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	DNA methylation Chromatin modifications during the maternal to zygotic transition (MZT)
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Asthma and attention deficit hyperactivity disorder ( 31619474) Diastolic blood pressure ( 30224653) Shoulder impingement or rotator cuff tear ( 33482370)	Age at first sexual intercourse ( 34211149) Appendicular lean mass ( 33097823) Birth weight ( 31043758) Hip circumference adjusted for BMI ( 34021172) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Mental health study participation (completed survey) ( 31263887) Systolic blood pressure ( 30578418) Type 2 diabetes ( 30297969) Urate levels ( 31578528)
Interacting Genes		223 interacting genes: AMBRA1 AMFR ANAPC11 AREL1 ARIH1 ARIH2 ARK2C ATXN3 BARD1 BFAR BIRC2 BIRC3 BIRC7 BIRC8 BMI1 BRCA1 CADPS2 CBL CBLC CHFR CNOT4 CRBN CSNK2A1 CUL2 CUL4B DBN1 DCAF1 DCUN1D1 DTX1 DTX2 DTX3 DTX3L DZIP3 EPS15 F12 FBXL12 FBXL2 FBXO2 FBXO25 FBXO4 FBXO7 FBXW10 FBXW11 FBXW8 FOCAD FZR1 H2AC4 HDAC6 HECTD1 HECTD3 HECW1 HECW2 HERC1 HERC2 HSP90AB1 HSPA1A IKBKG ITCH KAT2B KDM1B KLHL3 LRSAM1 MAEA MAP3K1 MAPT MARCHF3 MARCHF5 MARCHF7 MARCHF8 MDM2 MDM4 MEX3B MEX3C MGRN1 MIB1 MID1 MID2 MKRN1 MKRN3 MSL1 MSL2 MUL1 MYCBP2 MYLIP NBR1 NEDD4 NEDD4L NFKB1 NFKBIA NHLRC1 NOSIP OTUB1 PCGF1 PCGF2 PCGF3 PCGF5 PCGF6 PCNA PDCD5 PELI1 PJA1 PJA2 POLL POLM PPP4C PRPF19 RABGEF1 RBCK1 RBX1 RCHY1 RELA RFFL RFWD3 RIGI RING1 RLIM RMND5B RNF103 RNF111 RNF113A RNF114 RNF115 RNF122 RNF125 RNF126 RNF13 RNF130 RNF14 RNF150 RNF166 RNF167 RNF168 RNF181 RNF185 RNF19B RNF2 RNF213 RNF216 RNF220 RNF26 RNF31 RNF34 RNF38 RNF4 RNF41 RNF43 RNF5 RNF8 RNFT1 RPLP1 RSPRY1 SAT1 SH3RF1 SIAH1 SIAH2 SMURF1 SMURF2 STAM2 STAU1 STK25 STUB1 SYVN1 TMEM129 TOPORS TRAF6 TRAIP TRIM10 TRIM13 TRIM17 TRIM2 TRIM21 TRIM23 TRIM25 TRIM26 TRIM27 TRIM28 TRIM3 TRIM31 TRIM32 TRIM33 TRIM35 TRIM37 TRIM38 TRIM39 TRIM43 TRIM45 TRIM5 TRIM50 TRIM54 TRIM55 TRIM58 TRIM62 TRIM63 TRIM68 TRIM69 TRIM7 TRIM8 TUBA1A UBA1 UBA6 UBASH3B UBC UBE2O UBE3A UBE3C UBE4A UBE4B UBOX5 UBR5 UFM1 UHRF1 USP7 UVSSA VHL WSB1 WWP1 WWP2 XIAP XPNPEP1 ZNF598 ZNRF1 ZNRF2 ZNRF4	36 interacting genes: AKT1 ATR DNMT3A ERCC1 ERG FANCD2 FZR1 H2AC4 H2BC3 H3-3A H3-4 H3C1 H3C13 H3C14 H3C15 H4C14 KAT5 KIF11 LASP1 LIG1 MBD4 MUS81 NR3C1 PCLAF PCNA PLK1 PRKACA SAP30 TP53 UBC UBE2D1 UBE2D2 UBE2D3 UBE2N UHRF2 USP7
Entrez ID		7323	29128
HPRD ID		04269	06992
Ensembl ID		ENSG00000109332	ENSG00000276043
Uniprot IDs		D6RAH7 P61077	A0A087WVR3 Q96T88
PDB IDs		1X23 2FUH 3L1Z 3RPG 3UGB 4BVU 4R8P 4S3O 5EGG 5IFR 6CP0 6T7F 7JZV 7LYB 8AMS 8GRQ 8SMW 8SMX 8SMY 8SMZ 8SN0 8SN1 8SN2 8SN3 8SN4 8SN5 8SN6 8SN7 8SN8 8SN9 8SNA 8U14 8UPF 8UQ8 8UQ9 8UQA 8UQB 8UQC 8UQD 8UQE 8X7I 8X7J 8X7K 9IPU	2FAZ 2L3R 2LGG 2LGK 2LGL 2PB7 3ASK 3ASL 3BI7 3CLZ 3DB3 3DB4 3DWH 3FL2 3SHB 3SOU 3SOW 3SOX 3T6R 3ZVY 3ZVZ 4GY5 4QQD 5C6D 5IAY 5XPI 5YY9 5YYA 6B9M 6IIW 6VCS 6VED 6VYJ 6W92 7FB7 8JIG 8WMS 8XV4 8XV6 8XV7 8XV8
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Modification Process Protein Polyubiquitination Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Transferase Activity Protein Metabolic Process Macromolecule Catabolic Process Zinc Ion Binding Proteolysis Macromolecule Metabolic Process Catabolic Process Metal Ion Binding Proteasomal Protein Catabolic Process Protein Catabolic Process Protein Autoubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Protein K63-linked Ubiquitination Ubiquitin Ligase Complex Cytoplasm Response To Stress Cellular Response To Stress Protein Monoubiquitination Regulation Of Signal Transduction Ubiquitin-ubiquitin Ligase Activity Regulation Of Signaling Regulation Of Post-translational Protein Modification Regulation Of Cell Communication Ubiquitin Protein Ligase Binding Positive Regulation Of Catabolic Process Ubiquitin Binding Cytosol Regulation Of Protein Ubiquitination Positive Regulation Of Protein Metabolic Process Suppression Of Viral Release By Host Innate Immune Response Positive Regulation Of Post-translational Protein Modification Regulation Of Intracellular Signal Transduction Negative Regulation Of Signal Transduction DNA Damage Response Positive Regulation Of Protein Ubiquitination Regulation Of Protein Catabolic Process Immune System Process Negative Regulation Of Signaling	Nucleoplasm Nucleus DNA Repair Nucleosome Chromosome Structural Constituent Of Chromatin Chromatin Organization Chromatin Remodeling DNA Metabolic Process DNA Damage Response DNA Binding Nucleosome Assembly Nucleosome Organization Cellular Response To Stress Chromosome Organization Protein Heterodimerization Activity Chromosome, Telomeric Region Protein-DNA Complex Assembly Macromolecule Metabolic Process Telomere Organization Negative Regulation Of Macromolecule Metabolic Process Double-strand Break Repair Negative Regulation Of Nucleobase-containing Compound Metabolic Process Signal Transduction In Response To DNA Damage DNA Damage Checkpoint Signaling Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Nucleic Acid Metabolic Process Regulation Of Anaphase-promoting Complex-dependent Catabolic Process TORC1 Signaling Response To Radiation Negative Regulation Of TORC1 Signaling Protein-containing Complex Mitotic DNA Damage Checkpoint Signaling Protein Ubiquitination Negative Regulation Of Transcription By RNA Polymerase II Mitotic DNA Integrity Checkpoint Signaling Chromatin Binding Response To Ionizing Radiation Regulation Of DNA Metabolic Process Regulation Of Chromosome Organization Ubiquitin Conjugating Enzyme Activity Response To UV TOR Signaling Cellular Response To Nutrient Levels Regulation Of Cell Cycle Protein Modification By Small Protein Conjugation Regulation Of Cellular Response To Stress Negative Regulation Of TOR Signaling
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