UBE2D3 and RBX1

Number of citations of the paper that reports this interaction (PubMedID 37243816)
79

Data Source:
BioGRID (pull down)

		UBE2D3	RBX1
Description		ubiquitin conjugating enzyme E2 D3	ring-box 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Endosome Cytosol Plasma Membrane Endosome Membrane Membrane Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Cytosol SCF Ubiquitin Ligase Complex VCB Complex Cullin-RING Ubiquitin Ligase Complex Cul2-RING Ubiquitin Ligase Complex Cul3-RING Ubiquitin Ligase Complex Cul4A-RING E3 Ubiquitin Ligase Complex Cul4B-RING E3 Ubiquitin Ligase Complex Cul5-RING Ubiquitin Ligase Complex Cul7-RING Ubiquitin Ligase Complex Cul4-RING E3 Ubiquitin Ligase Complex Site Of DNA Damage
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity NEDD8 Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin-ubiquitin Ligase Activity Protein-containing Complex Binding Metal Ion Binding Molecular Adaptor Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Ubiquitin Protein Ligase Activity NEDD8 Ligase Activity Cullin Family Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination DNA Repair Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Apoptotic Process DNA Damage Response Protein Ubiquitination Negative Regulation Of BMP Signaling Pathway Protein Modification Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein K6-linked Ubiquitination Positive Regulation Of Protein Targeting To Mitochondrion	Autophagosome Assembly G1/S Transition Of Mitotic Cell Cycle MAPK Cascade Protein Polyubiquitination Mitophagy Epithelial To Mesenchymal Transition DNA Repair Transcription-coupled Nucleotide-excision Repair Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Apoptotic Process DNA Damage Response Response To Oxidative Stress Lysosome Organization Spermatogenesis Regulation Of Mitotic Cell Cycle Insulin Receptor Signaling Pathway Negative Regulation Of Autophagy Positive Regulation Of Autophagy Protein Ubiquitination Cytokine-mediated Signaling Pathway Protein Catabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Nutrient Levels Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Cellular Response To Insulin Stimulus Cellular Response To Amino Acid Starvation Cellular Response To Oxidative Stress Cellular Response To UV MiRNA-mediated Gene Silencing By MRNA Destabilization P38MAPK Cascade TORC1 Signaling T Cell Activation Signal Transduction In Response To DNA Damage Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Protein Neddylation Positive Regulation Of Translation Positive Regulation Of Protein Catabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Insulin Receptor Signaling Pathway Type I Interferon-mediated Signaling Pathway Cellular Response To Chemical Stress Renal Sodium Ion Absorption Protein K48-linked Ubiquitination Cellular Response To Amino Acid Stimulus Negative Regulation Of Canonical Wnt Signaling Pathway Base-excision Repair, AP Site Formation Via Deaminated Base Removal Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway RNA Polymerase II Transcription Initiation Surveillance Regulation Of Cellular Response To Insulin Stimulus Negative Regulation Of Mitophagy Negative Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Autoubiquitination Negative Regulation Of Response To Oxidative Stress Positive Regulation Of Epithelial Cell Apoptotic Process Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways		Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha TICAM1, RIP1-mediated IKK complex recruitment Signaling by BMP Downregulation of SMAD2/3:SMAD4 transcriptional activity PINK1-PRKN Mediated Mitophagy Regulation of TNFR1 signaling E3 ubiquitin ligases ubiquitinate target proteins Neddylation Peroxisomal protein import Negative regulators of DDX58/IFIH1 signaling IKK complex recruitment mediated by RIP1 Inactivation of CSF3 (G-CSF) signaling Antigen processing: Ubiquitination & Proteasome degradation ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	Recognition of DNA damage by PCNA-containing replication complex Prolactin receptor signaling Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Vif-mediated degradation of APOBEC3G Degradation of beta-catenin by the destruction complex NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Degradation of DVL Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Orc1 removal from chromatin Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A FBXL7 down-regulates AURKA during mitotic entry and in early mitosis Regulation of RUNX2 expression and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling Potential therapeutics for SARS Regulation of BACH1 activity Nuclear events stimulated by ALK signaling in cancer KEAP1-NFE2L2 pathway GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Antigen processing: Ubiquitination & Proteasome degradation Evasion by RSV of host interferon responses GSK3B-mediated proteasomal degradation of PD-L1(CD274) SPOP-mediated proteasomal degradation of PD-L1(CD274) Degradation of CRY and PER proteins Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Asthma and attention deficit hyperactivity disorder ( 31619474) Diastolic blood pressure ( 30224653) Shoulder impingement or rotator cuff tear ( 33482370)	Alcohol use disorder (consumption score) ( 30940813) Allergic rhinitis ( 25085501) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Crohn's disease ( 22936669) LDL cholesterol levels ( 32203549) Neuroticism ( 29255261) Refractive error ( 32231278)
Interacting Genes		223 interacting genes: AMBRA1 AMFR ANAPC11 AREL1 ARIH1 ARIH2 ARK2C ATXN3 BARD1 BFAR BIRC2 BIRC3 BIRC7 BIRC8 BMI1 BRCA1 CADPS2 CBL CBLC CHFR CNOT4 CRBN CSNK2A1 CUL2 CUL4B DBN1 DCAF1 DCUN1D1 DTX1 DTX2 DTX3 DTX3L DZIP3 EPS15 F12 FBXL12 FBXL2 FBXO2 FBXO25 FBXO4 FBXO7 FBXW10 FBXW11 FBXW8 FOCAD FZR1 H2AC4 HDAC6 HECTD1 HECTD3 HECW1 HECW2 HERC1 HERC2 HSP90AB1 HSPA1A IKBKG ITCH KAT2B KDM1B KLHL3 LRSAM1 MAEA MAP3K1 MAPT MARCHF3 MARCHF5 MARCHF7 MARCHF8 MDM2 MDM4 MEX3B MEX3C MGRN1 MIB1 MID1 MID2 MKRN1 MKRN3 MSL1 MSL2 MUL1 MYCBP2 MYLIP NBR1 NEDD4 NEDD4L NFKB1 NFKBIA NHLRC1 NOSIP OTUB1 PCGF1 PCGF2 PCGF3 PCGF5 PCGF6 PCNA PDCD5 PELI1 PJA1 PJA2 POLL POLM PPP4C PRPF19 RABGEF1 RBCK1 RBX1 RCHY1 RELA RFFL RFWD3 RIGI RING1 RLIM RMND5B RNF103 RNF111 RNF113A RNF114 RNF115 RNF122 RNF125 RNF126 RNF13 RNF130 RNF14 RNF150 RNF166 RNF167 RNF168 RNF181 RNF185 RNF19B RNF2 RNF213 RNF216 RNF220 RNF26 RNF31 RNF34 RNF38 RNF4 RNF41 RNF43 RNF5 RNF8 RNFT1 RPLP1 RSPRY1 SAT1 SH3RF1 SIAH1 SIAH2 SMURF1 SMURF2 STAM2 STAU1 STK25 STUB1 SYVN1 TMEM129 TOPORS TRAF6 TRAIP TRIM10 TRIM13 TRIM17 TRIM2 TRIM21 TRIM23 TRIM25 TRIM26 TRIM27 TRIM28 TRIM3 TRIM31 TRIM32 TRIM33 TRIM35 TRIM37 TRIM38 TRIM39 TRIM43 TRIM45 TRIM5 TRIM50 TRIM54 TRIM55 TRIM58 TRIM62 TRIM63 TRIM68 TRIM69 TRIM7 TRIM8 TUBA1A UBA1 UBA6 UBASH3B UBC UBE2O UBE3A UBE3C UBE4A UBE4B UBOX5 UBR5 UFM1 UHRF1 USP7 UVSSA VHL WSB1 WWP1 WWP2 XIAP XPNPEP1 ZNF598 ZNRF1 ZNRF2 ZNRF4	78 interacting genes: APP ARIH1 ARIH2 CAND1 CAND2 CCND1 CCNK CDC34 CFLAR COPS4 COPS6 CSNK1E CUL1 CUL3 CUL4A CUL4B CUL5 CUL7 ELOB ELOC ERBIN ERCC8 FBH1 FBXL2 FBXO45 FBXW8 FRZB GHR GLMN GPS1 HAX1 KCTD17 KEAP1 KLHDC2 KLHL22 KLHL3 KPNB1 KRTAP12-2 MAGEC2 MAP3K20 MAP3K7 MAPK8IP2 MKNK2 MYB NEURL2 OS9 PBX4 PML PRAME RHOBTB3 RNF126 RPS6KB1 SERTAD1 SKP1 SMAD3 SNAI1 TAB1 TRIM27 TRIM74 UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2F UBE2G1 UBE2G2 UBE2H UBE2L3 UBE2L6 UBE2M UBE2N UBE2R2 VHL VRK2
Entrez ID		7323	9978
HPRD ID		04269	06794
Ensembl ID		ENSG00000109332	ENSG00000100387
Uniprot IDs		D6RAH7 P61077	P62877
PDB IDs		1X23 2FUH 3L1Z 3RPG 3UGB 4BVU 4R8P 4S3O 5EGG 5IFR 6CP0 6T7F 7JZV 7LYB 8AMS 8GRQ 8SMW 8SMX 8SMY 8SMZ 8SN0 8SN1 8SN2 8SN3 8SN4 8SN5 8SN6 8SN7 8SN8 8SN9 8SNA 8U14 8UPF 8UQ8 8UQ9 8UQA 8UQB 8UQC 8UQD 8UQE 8X7I 8X7J 8X7K 9IPU	1LDJ 1LDK 1U6G 2HYE 2LGV 3DPL 3DQV 3RTR 4F52 4P5O 5N4W 6R6H 6R7F 6R7H 6R7I 6R7N 6TTU 7B5L 7B5M 7B5N 7B5S 7OKQ 7PLO 7Z8B 7Z8R 7Z8T 7Z8V 7ZBW 7ZBZ 8B3G 8B3I 8CDJ 8CDK 8GQ6 8H33 8H34 8H35 8H36 8H37 8H38 8H3A 8H3F 8H3Q 8H3R 8IJ1 8JAQ 8JAS 8JAV 8JE1 8K9I 8KHP 8OR0 8OR2 8OR3 8OR4 8PQL 8Q7E 8Q7H 8Q7R 8QU8 8R5H 8RHZ 8RWZ 8RX0 8UBU 8WDK 8WQA 8WQB 8WQC 8WQE 8WQF 8WQG 8WQH 9JKB 9KBD
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Modification Process Protein Polyubiquitination Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Transferase Activity Protein Metabolic Process Macromolecule Catabolic Process Zinc Ion Binding Proteolysis Macromolecule Metabolic Process Catabolic Process Metal Ion Binding Proteasomal Protein Catabolic Process Protein Catabolic Process Protein Autoubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Protein K63-linked Ubiquitination Ubiquitin Ligase Complex Cytoplasm Response To Stress Cellular Response To Stress Protein Monoubiquitination Regulation Of Signal Transduction Ubiquitin-ubiquitin Ligase Activity Regulation Of Signaling Regulation Of Post-translational Protein Modification Regulation Of Cell Communication Ubiquitin Protein Ligase Binding Positive Regulation Of Catabolic Process Ubiquitin Binding Cytosol Regulation Of Protein Ubiquitination Positive Regulation Of Protein Metabolic Process Suppression Of Viral Release By Host Innate Immune Response Positive Regulation Of Post-translational Protein Modification Regulation Of Intracellular Signal Transduction Negative Regulation Of Signal Transduction DNA Damage Response Positive Regulation Of Protein Ubiquitination Regulation Of Protein Catabolic Process Immune System Process Negative Regulation Of Signaling	Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Ubiquitination Protein Modification Process Proteolysis Involved In Protein Catabolic Process Macromolecule Catabolic Process Protein Metabolic Process Proteasomal Protein Catabolic Process Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Polyubiquitination Protein K48-linked Ubiquitination Protein Catabolic Process Ubiquitin Conjugating Enzyme Activity Catabolic Process Ubiquitin-protein Transferase Activity Macromolecule Metabolic Process Cullin-RING Ubiquitin Ligase Complex Protein Monoubiquitination Cytosol Ubiquitin-like Ligase-substrate Adaptor Activity Ubiquitin Protein Ligase Binding Ubiquitin Ligase Complex Scaffold Activity Nucleus Protein K11-linked Ubiquitination Regulation Of Protein Metabolic Process Cul2-RING Ubiquitin Ligase Complex G1/S Transition Of Mitotic Cell Cycle Cellular Response To Stress Ubiquitin-like Protein Transferase Activity Cell Cycle G1/S Phase Transition Cell Cycle Phase Transition Transferase Activity SCF Ubiquitin Ligase Complex Nucleoplasm Cytoplasm Response To Stress Protein K63-linked Ubiquitination Mitotic Cell Cycle Phase Transition Ubiquitin Ligase Complex Cul4A-RING E3 Ubiquitin Ligase Complex ATP Binding Cul3-RING Ubiquitin Ligase Complex Protein Binding Regulation Of Intracellular Signal Transduction SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of TORC1 Signaling
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