TRIM25 and USP39

Number of citations of the paper that reports this interaction (PMID 23105109)
4

Data Source:
BioGRID (two hybrid)

		TRIM25	USP39
Gene Name		tripartite motif containing 25	ubiquitin specific peptidase 39
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol	Spliceosomal Complex
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Zinc Ion Binding Acid-amino Acid Ligase Activity Poly(A) RNA Binding	Zinc Ion Binding Ubiquitinyl Hydrolase Activity
	Biological Process	Viral Process Protein Ubiquitination Cytokine-mediated Signaling Pathway Negative Regulation Of Type I Interferon Production Response To Vitamin D Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Estrogen Innate Immune Response Regulation Of Viral Entry Into Host Cell Negative Regulation Of Viral Entry Into Host Cell Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Regulation Of Viral Release From Host Cell Negative Regulation Of Viral Release From Host Cell	Spliceosomal Complex Assembly MRNA Processing Ubiquitin-dependent Protein Catabolic Process Cell Cycle RNA Splicing Cell Division
Pathways		Negative regulators of RIG-I/MDA5 signaling ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Antiviral mechanism by IFN-stimulated genes Interferon gamma signaling RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Innate Immune System
Drugs
Diseases
GWAS		Height ( 18391951)
Protein-Protein Interactions		27 interactors: AMFR DDX58 ERCC2 ESR1 GATA1 GRIK2 MEIS2 OTUB2 PITX2 RARRES3 RBCK1 RNF31 SFN STK38 TFG TRAF6 TRIM8 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2J2 UBE2L6 UBE2N USP15 USP39 ZNF24	11 interactors: ACVR1 APP SAE1 SP1 SRPK1 TRAF6 TRIM25 TRIM26 TRIM39 TRIM5 TRIM8
Entrez ID		7706	10713
HPRD ID		02711	07165
Ensembl ID		ENSG00000121060	ENSG00000168883
Uniprot IDs		Q14258	B3KMG1 B7Z7L9 Q53GS9
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Cellular Macromolecule Catabolic Process Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of I-kappaB Kinase/NF-kappaB Signaling Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Response To Organic Substance Activation Of Innate Immune Response Proteolysis Immune Response-regulating Signaling Pathway Toll-like Receptor 4 Signaling Pathway Cellular Protein Modification Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Innate Immune Response Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein K48-linked Ubiquitination Toll-like Receptor Signaling Pathway Immune System Process Catabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Innate Immune Response Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Protein Metabolic Process Signaling Positive Regulation Of Immune Response Positive Regulation Of Immune System Process Proteasomal Protein Catabolic Process Cell Communication Response To Stimulus Cellular Response To Stimulus Regulation Of Immune System Process TRIF-dependent Toll-like Receptor Signaling Pathway Signal Transduction Cellular Metabolic Process Negative Regulation Of Gene Expression MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Transcription, DNA-templated Innate Immune Response Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Response To Organic Substance	Negative Regulation Of Viral Release From Host Cell Regulation Of Viral Process Negative Regulation Of Viral Entry Into Host Cell Regulation Of Viral Entry Into Host Cell Negative Regulation Of Viral Process Regulation Of Viral Release From Host Cell Defense Response Innate Immune Response Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Interferon-gamma-mediated Signaling Pathway Immune Response Cellular Response To Interferon-gamma Immune System Process Cellular Protein Modification Process Response To Interferon-gamma Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cytokine-mediated Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Metabolic Process Negative Regulation Of Locomotion Cellular Response To Cytokine Stimulus Regulation Of Signal Transduction Cellular Response To Organic Substance Negative Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Signal Transduction Cellular Protein Metabolic Process Response To Cytokine Regulation Of Signaling Cell Surface Receptor Signaling Pathway Regulation Of RNA Metabolic Process Response To Stress Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Response To Organic Substance Regulation Of Lipopolysaccharide-mediated Signaling Pathway Atrial Septum Development Signal Transduction Regulation Of Activin Receptor Signaling Pathway Protein Metabolic Process Viral Process Signaling Cell Communication Protein K63-linked Ubiquitination Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process
Tagcloud ?		accelerates amf autocrine catalyzes cooperates cooperative dhfr e4 erad gauges gp78 illustrated insight isomerase ligase mechanistic motility pgi phosphoglucose polyubiquitylation round steady tripartite ub ubiquitin ubiquitylates ubiquitylation uncovers vital
Tagcloud (Difference) ?		accelerates amf autocrine catalyzes cooperates cooperative dhfr e4 erad gauges gp78 illustrated insight isomerase ligase mechanistic motility pgi phosphoglucose polyubiquitylation round steady tripartite ub ubiquitin ubiquitylates ubiquitylation uncovers vital
Tagcloud (Intersection) ?