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TRIM25 and PTEN
Number of citations of the paper that reports this interaction (PubMedID
34416231
)
39
Data Source:
BioGRID
(enzymatic study)
TRIM25
PTEN
Description
tripartite motif containing 25
phosphatase and tensin homolog
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Cytoplasmic Stress Granule
Nuclear Body
Extracellular Region
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
Cytoplasmic Side Of Plasma Membrane
Postsynaptic Density
Apical Plasma Membrane
PML Body
Myelin Sheath Adaxonal Region
Cell Projection
Neuron Projection
Dendritic Spine
Schmidt-Lanterman Incisure
Synapse
Molecular Function
Transcription Coactivator Activity
RNA Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Transferase Activity
Ligase Activity
RIG-I Binding
Cadherin Binding
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Phosphatidylinositol-3-phosphate Phosphatase Activity
Phosphoprotein Phosphatase Activity
Protein Serine/threonine Phosphatase Activity
Protein Tyrosine Phosphatase Activity
Protein Binding
Beta-catenin Binding
Lipid Binding
Anaphase-promoting Complex Binding
Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity
Hydrolase Activity
Phosphatase Activity
Enzyme Binding
PDZ Domain Binding
Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity
Identical Protein Binding
Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity
Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity
Phosphatidylinositol Phosphate Phosphatase Activity
Molecular Function Inhibitor Activity
Ubiquitin-specific Protease Binding
Ubiquitin Ligase Activator Activity
Biological Process
Immune System Process
Cytoplasmic Pattern Recognition Receptor Signaling Pathway
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
Response To Oxidative Stress
MRNA Transcription
Protein Ubiquitination
Viral Release From Host Cell
Regulation Of Protein Localization
Response To Vitamin D
Cellular Response To Oxidative Stress
ERAD Pathway
RIG-I Signaling Pathway
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Response To Estrogen
Suppression Of Viral Release By Host
Innate Immune Response
Positive Regulation Of DNA-templated Transcription
Regulation Of Viral Entry Into Host Cell
Host-mediated Suppression Of Symbiont Invasion
Defense Response To Virus
Protein K48-linked Ubiquitination
Antiviral Innate Immune Response
Cellular Response To Leukemia Inhibitory Factor
Osteoblast Differentiation
Protein Dephosphorylation
Lipid Metabolic Process
Phosphatidylinositol Biosynthetic Process
Apoptotic Process
Spindle Assembly Involved In Female Meiosis
Neuron-neuron Synaptic Transmission
Nervous System Development
Synapse Assembly
Central Nervous System Development
Heart Development
Learning Or Memory
Locomotory Behavior
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Regulation Of Signal Transduction
Positive Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Cell Communication
Negative Regulation Of Epithelial To Mesenchymal Transition
Regulation Of Neuron Projection Development
Negative Regulation Of Neuron Projection Development
Cell Migration
Dentate Gyrus Development
Central Nervous System Neuron Axonogenesis
Negative Regulation Of Signaling
Negative Regulation Of Cell Migration
Adult Behavior
Regulation Of Protein Stability
Central Nervous System Myelin Maintenance
Negative Regulation Of Peptidyl-serine Phosphorylation
Multicellular Organismal Response To Stress
Social Behavior
Maternal Behavior
Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Locomotor Rhythm
Regulation Of Cell Differentiation
Negative Regulation Of Osteoblast Differentiation
Negative Regulation Of Cell Size
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Organ Growth
Phosphatidylinositol Dephosphorylation
Forebrain Morphogenesis
Cell Motility
Negative Regulation Of Axonogenesis
Protein Stabilization
Negative Regulation Of Developmental Process
Negative Regulation Of Cellular Component Organization
Negative Regulation Of Multicellular Organismal Process
Negative Regulation Of Keratinocyte Migration
Regulation Of Cell Cycle
Negative Regulation Of Focal Adhesion Assembly
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Rhythmic Synaptic Transmission
Synapse Maturation
Prepulse Inhibition
Dendritic Spine Morphogenesis
Regulation Of Biological Quality
Cellular Response To Electrical Stimulus
Negative Regulation Of Excitatory Postsynaptic Potential
Presynaptic Membrane Assembly
Postsynaptic Density Assembly
Positive Regulation Of Intracellular Signal Transduction
Negative Regulation Of Cell Cycle G1/S Phase Transition
Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells
Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Positive Regulation Of Excitatory Postsynaptic Potential
Negative Regulation Of Cellular Senescence
Negative Regulation Of Synaptic Vesicle Clustering
Pathways
ISG15 antiviral mechanism
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Termination of translesion DNA synthesis
Ovarian tumor domain proteases
Interferon gamma signaling
TRAF3-dependent IRF activation pathway
TRAF6 mediated IRF7 activation
TRAF6 mediated NF-kB activation
TRAF6 mediated NF-kB activation
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
Negative regulators of DDX58/IFIH1 signaling
Negative regulators of DDX58/IFIH1 signaling
SARS-CoV-1 activates/modulates innate immune responses
SARS-CoV-2 activates/modulates innate and adaptive immune responses
Evasion by RSV of host interferon responses
RSV-host interactions
PKR-mediated signaling
Modulation of host responses by IFN-stimulated genes
Synthesis of PIPs at the plasma membrane
Synthesis of IP3 and IP4 in the cytosol
Negative regulation of the PI3K/AKT network
Downstream TCR signaling
TP53 Regulates Metabolic Genes
PTEN Loss of Function in Cancer
Ub-specific processing proteases
Ovarian tumor domain proteases
Regulation of PTEN mRNA translation
Regulation of PTEN localization
Regulation of PTEN stability and activity
Transcriptional Regulation by MECP2
Drugs
Phosphatidylethanolamine
Diseases
Vulvar cancer
Breast cancer
Malignant melanoma
Prostate cancer
Hepatocellular carcinoma
Small cell lung cancer
Endometrial Cancer
Glioma
GWAS
Height (
18391951
)
Lean body mass (
28552196
)
Alanine aminotransferase levels (
33547301
)
Ambidextrousness (
32989287
)
Birth weight (
31043758
)
Eosinophil count (
27863252
32888494
)
Eosinophil percentage of granulocytes (
27863252
)
Eosinophil percentage of white cells (
32888494
27863252
)
Fasting insulin (
34059833
)
Height (
31562340
)
Liver enzyme levels (alanine transaminase) (
33972514
)
Lymphocyte percentage of white cells (
32888494
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Mercury levels (
26025379
)
Multiple sclerosis (
31604244
)
Neutrophil count (
32888494
)
Neutrophil percentage of granulocytes (
27863252
)
Neutrophil percentage of white cells (
32888494
)
Periodontitis (Mean PAL) (
24024966
)
Platelet count (
32888494
)
Plateletcrit (
32888494
)
Psoriasis (
28537254
)
Pulse pressure (
27841878
)
Red blood cell count (
32888494
)
Sum eosinophil basophil counts (
27863252
)
Systolic blood pressure and diastolic blood pressure (bivariate analysis) (
33539483
)
Thyroid stimulating hormone levels (
32769997
30367059
)
Type 2 diabetes (
32499647
24509480
)
Type 2 diabetes (adjusted for BMI) (
30297969
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
White blood cell count (
32888494
)
White blood cell count (basophil) (
29403010
)
Interacting Genes
77 interacting genes:
AMFR
APC
CASP7
CEBPA
CHKA
CRK
DDX3X
DICER1
EIF4G3
ERCC2
ERG
ESR1
G3BP1
G3BP2
GABARAP
GABARAPL1
GABARAPL2
GATA1
GRIK2
LINC00955
MAP1LC3A
MAP1LC3B
MAP1LC3C
MAP3K13
MEIS2
MIR1-1
MIR155
MIR16-2
MIR19B2
MIR205
MIR206
MIR21
MIR221
MIR25
MIR29A
MIR29B1
MIR34A
MIR363
MIR7-1
MIR92A1
MIR92A2
MIR98
MIRLET7A1
MIRLET7A3
MTA1
OTUB2
PAX2
PIK3R1
PITX2
PLAAT4
PTEN
RBCK1
RIPK3
RNF31
SFN
SLC26A4-AS1
STK11
STK38
SUMO2
TFG
TRAF6
TRIM8
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2J2
UBE2L3
UBE2L6
UBE2N
UBE2V1
USP15
USP39
YWHAQ
ZBTB7A
ZNF24
376 interacting genes:
AATK
ABCF2
ACTL6A
ADAR
AFP
AKAP12
AKT1
ALYREF
AMOT
ANAPC10
ANAPC7
ANG
ANP32B
ANP32E
ANXA2
AR
ARF4
ARMCX3
ASCC3
ATM
ATP5F1A
ATP5F1C
BCAR1
BEX1
BGLT3
BUB3
CACTIN-AS1
CAD
CALM1
CAMK2G
CAV1
CBL
CCDC180
CCDC47
CCND2
CCT2
CCT3
CCT4
CCT6A
CCT8
CDC27
CEP170
CEP97
CFL1
CHD4
CHGB
CMAS
COPA
COPB1
COPS6
CREB1
CSNK1A1
CSNK2A1
CSNK2A2
CUL4B
CXCL1
CXXC1
DAP3
DAXX
DBN1
DCAF11
DCAF13
DDB1
DDOST
DDX1
DDX21
DDX24
DDX47
DDX50
DHX15
DHX9
DLC1
DLG1
DNAJA1
DNAJA2
DNAJA3
DNAJB6
DNAJC10
DPM1
DRG1
DSP
EEF2
EIF4E
EIF6
EML1
EPHA2
EPRS1
ERBB3
ESR1
EXOSC1
EXOSC2
EXOSC4
EXOSC5
EXOSC7
FARSA
FARSB
FASN
FBL
FBXW11
FLNA
FOXK1
FUBP3
GEMIN4
GNAI1
GNAI2
GNB4
GNL3
GPC4
GSTM2
GTF3C2
GTF3C3
GTF3C5
H2AC4
H2AX
HADHA
HBA1
HNRNPA1
HNRNPA3
HNRNPAB
HNRNPUL1
HSD17B1
HSD17B10
HSP90B1
HSPA4
HSPA4L
HSPA8
HSPBP1
HSPD1
HSPH1
IL24
ILF2
ILF3
INS
IPO5
IPO7
IRS4
ITPRID2
JUP
KBTBD4
KDM1A
KPNB1
LATS1
LGALS1
LIMA1
LINC00839
LINC01198
LINC02023
LMNB1
LRPPRC
LTV1
MAGED2
MAGI2
MAGI3
MAP2K3
MAST1
MAST2
MAST3
MATR3
MCM2
MCM3
MCM5
MCRS1
MDC1
MDN1
METTL26
MEX3C
MKI67
MME
MPRIP
MRPS22
MRPS23
MRPS27
MRPS28
MRPS7
MRPS9
MSH6
MTHFD2
MVP
MYBBP1A
MYC
MYH10
MYL12A
MYO1B
MYO1C
MYO1D
MYOF
NACA
NCBP1
NCF1
NDFIP1
NEDD4
NGB
NHERF1
NHERF2
NOP56
NOP58
NPM3
NUMB
OSGIN1
PBK
PBRM1
PCNA
PDGFRB
PELO
PELP1
PHB1
PHB2
PICK1
PIK3R1
PKM
PLEC
PLK1
POLDIP2
POLR1A
POLR2A
POLR2B
POLR2H
POP1
PPL
PPP1CA
PPP2CA
PRDX1
PRDX3
PRKDC
PRPF19
PRPF8
PSMD3
PSMD4
PSMD7
PTDSS1
PTK7
PURA
PXN
QPCTL
RAD21
RANBP2
RANGAP1
RBBP5
RBM4
RCC2
RCN1
RFC3
RFC4
RFC5
RING1
RNF31
RPL10
RPL10A
RPL12
RPL13
RPL13A
RPL14
RPL17
RPL18A
RPL21
RPL22
RPL22L1
RPL23
RPL23A
RPL27
RPL27A
RPL28
RPL30
RPL31
RPL32
RPL34
RPL36
RPL38
RPL7
RPLP0
RPLP2
RPN2
RPP30
RPP38
RPP40
RPS11
RPS13
RPS15
RPS15A
RPS17
RPS2
RPS20
RPS23
RPS25
RPS26
RPS27
RPS27A
RPS3
RPS4X
RPS5
RPS6
RPS9
RSL1D1
RYBP
S100A8
S100A9
SDC1
SDC4
SDCBP
SEC61A1
SET
SETX
SHARPIN
SHROOM3
SIN3A
SIRT4
SKP1
SLC25A1
SLC25A13
SLC25A3
SLC25A5
SMARCA4
SMARCA5
SMC2
SMC4
SMCHD1
SMURF1
SNAI1
SNRNP200
SNRPA1
SNRPB2
SNRPD1
SNTB2
SNX27
SPOP
SPTAN1
SPTBN1
SRP14
SSB
SSR4
SSRP1
STAG2
STK11
STRAP
SUDS3
SUGP2
TCF25
TCP1
TECR
TERF2IP
THOC2
THOC3
THOC6
TMEFF1
TNKS
TNKS2
TNPO3
TP53
TP53BP1
TRIM25
TRIM28
TRMO
TUBA1B
TUBB
TUBB4B
TUFM
TWIST1
TXN
U2AF1
UBE2I
UBE2L3
UPF1
USP7
USP9X
UTP14A
UTRN
WWP1
WWP2
XRCC5
XRCC6
YAF2
YAP1
YES1
YTHDC2
YTHDF2
ZNF326
Entrez ID
7706
5728
HPRD ID
02711
03431
Ensembl ID
ENSG00000121060
ENSG00000171862
Uniprot IDs
Q14258
F6KD01
P60484
PDB IDs
4CFG
4LTB
5EYA
5FER
5NT1
5NT2
6FLM
6FLN
1D5R
2KYL
4O1V
5BUG
5BZX
5BZZ
7JTX
7JUK
7JUL
7JVX
7PC7
8X3S
Enriched GO Terms of Interacting Partners
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Post-transcriptional Gene Silencing
RISC Complex
MiRNA-mediated Post-transcriptional Gene Silencing
Regulatory NcRNA-mediated Post-transcriptional Gene Silencing
Regulatory NcRNA-mediated Gene Silencing
MRNA Base-pairing Post-transcriptional Repressor Activity
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
Post-transcriptional Regulation Of Gene Expression
Ubiquitin Conjugating Enzyme Activity
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Gene Expression
Negative Regulation Of Macromolecule Biosynthetic Process
Regulation Of Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Cellular Response To Nitrogen Starvation
MiRNA-mediated Gene Silencing By Inhibition Of Translation
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Negative Regulation Of Signal Transduction
Ubiquitin Protein Ligase Binding
Regulation Of Protein Metabolic Process
Phosphatidylethanolamine Binding
Protein Polyubiquitination
Regulation Of Intracellular Signal Transduction
Regulation Of Signal Transduction
MRNA 3'-UTR Binding
Cellular Response To Stress
Negative Regulation Of Gene Expression
Post-translational Protein Modification
Response To Stress
Regulation Of Primary Metabolic Process
Negative Regulation Of Intracellular Signal Transduction
Positive Regulation Of Macromolecule Metabolic Process
Protein Modification Process
Positive Regulation Of Metabolic Process
Regulation Of Signaling
Regulation Of Cell Communication
Negative Regulation Of Translation
Positive Regulation Of Protein Polyubiquitination
Ubiquitin-protein Transferase Activity
Negative Regulation Of Cell Population Proliferation
Positive Regulation Of Protein Ubiquitination
Regulation Of RNA Metabolic Process
Positive Regulation Of DNA-binding Transcription Factor Activity
Negative Regulation Of Cell Motility
Negative Regulation Of Protein Metabolic Process
Protein Modification By Small Protein Conjugation
Negative Regulation Of Locomotion
RNA Binding
Ribonucleoprotein Complex
Cytosolic Ribosome
Cytoplasmic Translation
Structural Constituent Of Ribosome
Ribosome
Macromolecule Metabolic Process
Translation
Nucleolus
Nucleoplasm
Nucleic Acid Metabolic Process
Macromolecule Biosynthetic Process
Nucleobase-containing Compound Metabolic Process
Cytosol
Nucleus
Cytosolic Large Ribosomal Subunit
Cytoplasm
RNA Metabolic Process
Extracellular Exosome
Focal Adhesion
RRNA Metabolic Process
Protein Metabolic Process
Cytosolic Small Ribosomal Subunit
Ribonucleoprotein Complex Biogenesis
RNA Processing
Regulation Of DNA Metabolic Process
Protein Binding
Small Ribosomal Subunit
ATP Binding
Chromosome, Telomeric Region
ATP Hydrolysis Activity
Small-subunit Processome
Positive Regulation Of DNA Biosynthetic Process
RRNA Processing
Positive Regulation Of DNA Metabolic Process
Regulation Of Chromosome Organization
Ribosomal Small Subunit Biogenesis
MRNA Metabolic Process
Nucleotide Binding
DNA Metabolic Process
Protein Localization To Organelle
Nucleocytoplasmic Transport
Nuclear Transport
Regulation Of Telomere Maintenance
Positive Regulation Of Protein Localization To Nucleus
ATP-dependent Protein Folding Chaperone
Positive Regulation Of Chromosome Organization
Positive Regulation Of Telomere Maintenance Via Telomerase
Chromosome
Cadherin Binding
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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