TRIM25 and MTA1

Number of citations of the paper that reports this interaction (PubMedID 28861931)
0

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		TRIM25	MTA1
Description		tripartite motif containing 25	metastasis associated 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoplasmic Stress Granule Nuclear Body	Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Cytosol Cytoskeleton Microtubule NuRD Complex
	Molecular Function	Transcription Coactivator Activity RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ligase Activity RIG-I Binding Cadherin Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Chromatin Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Histone Deacetylase Binding Sequence-specific DNA Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Immune System Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Response To Oxidative Stress MRNA Transcription Protein Ubiquitination Viral Release From Host Cell Regulation Of Protein Localization Response To Vitamin D Cellular Response To Oxidative Stress ERAD Pathway RIG-I Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Response To Estrogen Suppression Of Viral Release By Host Innate Immune Response Positive Regulation Of DNA-templated Transcription Regulation Of Viral Entry Into Host Cell Host-mediated Suppression Of Symbiont Invasion Defense Response To Virus Protein K48-linked Ubiquitination Antiviral Innate Immune Response Cellular Response To Leukemia Inhibitory Factor	Negative Regulation Of Transcription By RNA Polymerase II Double-strand Break Repair Chromatin Remodeling Regulation Of DNA-templated Transcription Signal Transduction Response To Ionizing Radiation Circadian Regulation Of Gene Expression Regulation Of Cell Fate Specification Entrainment Of Circadian Clock By Photoperiod Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Locomotor Rhythm Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Rhythmic Process Positive Regulation Of Protein Autoubiquitination Regulation Of Stem Cell Differentiation
Pathways		ISG15 antiviral mechanism DDX58/IFIH1-mediated induction of interferon-alpha/beta Termination of translesion DNA synthesis Ovarian tumor domain proteases Interferon gamma signaling TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses Evasion by RSV of host interferon responses RSV-host interactions PKR-mediated signaling Modulation of host responses by IFN-stimulated genes	HDACs deacetylate histones SUMOylation of transcription factors ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Potential therapeutics for SARS Regulation of endogenous retroelements by KRAB-ZFP proteins Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)
Drugs
Diseases
GWAS		Height ( 18391951) Lean body mass ( 28552196)	Heel bone mineral density ( 30598549)
Interacting Genes		77 interacting genes: AMFR APC CASP7 CEBPA CHKA CRK DDX3X DICER1 EIF4G3 ERCC2 ERG ESR1 G3BP1 G3BP2 GABARAP GABARAPL1 GABARAPL2 GATA1 GRIK2 LINC00955 MAP1LC3A MAP1LC3B MAP1LC3C MAP3K13 MEIS2 MIR1-1 MIR155 MIR16-2 MIR19B2 MIR205 MIR206 MIR21 MIR221 MIR25 MIR29A MIR29B1 MIR34A MIR363 MIR7-1 MIR92A1 MIR92A2 MIR98 MIRLET7A1 MIRLET7A3 MTA1 OTUB2 PAX2 PIK3R1 PITX2 PLAAT4 PTEN RBCK1 RIPK3 RNF31 SFN SLC26A4-AS1 STK11 STK38 SUMO2 TFG TRAF6 TRIM8 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2J2 UBE2L3 UBE2L6 UBE2N UBE2V1 USP15 USP39 YWHAQ ZBTB7A ZNF24	46 interacting genes: BLOC1S1 CCNH CSNK1G2 CYSRT1 DDX18 DYNLL1 DYRK1A E2F1 ERCC6 ESR1 FHL3 GPR183 GRB2 H3-4 HDAC1 HDAC2 HIF1A ITGB3BP JUN KHDRBS2 KPNA4 KRT31 KRT40 KRTAP10-8 LMO4 LRRK2 LZTS2 MAGEA11 MNAT1 NACC2 NBPF19 NELFCD NOTCH2NLA PICK1 PLEKHG4 RBBP4 SAT1 SH3GL1 SH3GLB1 SNAI1 SUMO2 TEX11 TP53 TRIM25 UBE2I ZEB2
Entrez ID		7706	9112
HPRD ID		02711	04633
Ensembl ID		ENSG00000121060	ENSG00000182979
Uniprot IDs		Q14258	E7ESY4 Q13330 Q9BRL8
PDB IDs		4CFG 4LTB 5EYA 5FER 5NT1 5NT2 6FLM 6FLN	4BKX 4PBY 4PBZ 4PC0 5FXY 5ICN 6G16 6ZRC 6ZRD 7AO8 7AO9 7AOA
Enriched GO Terms of Interacting Partners?		Post-transcriptional Gene Silencing RISC Complex MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Post-transcriptional Regulation Of Gene Expression Ubiquitin Conjugating Enzyme Activity Negative Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Cellular Response To Nitrogen Starvation MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Ubiquitin Protein Ligase Binding Regulation Of Protein Metabolic Process Phosphatidylethanolamine Binding Protein Polyubiquitination Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction MRNA 3'-UTR Binding Cellular Response To Stress Negative Regulation Of Gene Expression Post-translational Protein Modification Response To Stress Regulation Of Primary Metabolic Process Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Protein Modification Process Positive Regulation Of Metabolic Process Regulation Of Signaling Regulation Of Cell Communication Negative Regulation Of Translation Positive Regulation Of Protein Polyubiquitination Ubiquitin-protein Transferase Activity Negative Regulation Of Cell Population Proliferation Positive Regulation Of Protein Ubiquitination Regulation Of RNA Metabolic Process Positive Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Cell Motility Negative Regulation Of Protein Metabolic Process Protein Modification By Small Protein Conjugation Negative Regulation Of Locomotion	Negative Regulation Of Nucleobase-containing Compound Metabolic Process Histone Deacetylase Binding Negative Regulation Of RNA Metabolic Process Regulation Of Cell Fate Specification Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Nucleoplasm Transcription Regulator Complex Regulation Of Fibroblast Proliferation Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Cell Communication Regulation Of Signaling Eyelid Development In Camera-type Eye Regulation Of Cell Fate Commitment Regulation Of Transcription By RNA Polymerase II Cellular Response To Stress Enzyme Binding NuRD Complex Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Biosynthetic Process Regulation Of Signal Transduction Negative Regulation Of Apoptotic Process Transcription Factor TFIIK Complex Negative Regulation Of Macromolecule Metabolic Process Developmental Process Regulation Of Apoptotic Process Regulation Of Cell Population Proliferation Protein Lysine Delactylase Activity Fungiform Papilla Formation Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Programmed Cell Death Regulation Of Programmed Cell Death Sin3-type Complex Negative Regulation Of Macromolecule Biosynthetic Process CAK-ERCC2 Complex Protein Decrotonylase Activity Histone Decrotonylase Activity Negative Regulation Of Stem Cell Population Maintenance Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Nuclear Body Response To Oxidative Stress
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