TRIM25 and PITX2

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (pull down, two hybrid)

		TRIM25	PITX2
Description		tripartite motif containing 25	paired like homeodomain 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoplasmic Stress Granule Nuclear Body	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm
	Molecular Function	Transcription Coactivator Activity RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Ligase Activity RIG-I Binding Cadherin Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Chromatin DNA Binding Identical Protein Binding Protein Homodimerization Activity Ribonucleoprotein Complex Binding Sequence-specific DNA Binding Phosphoprotein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Immune System Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Response To Oxidative Stress MRNA Transcription Protein Ubiquitination Viral Release From Host Cell Regulation Of Protein Localization Response To Vitamin D Cellular Response To Oxidative Stress ERAD Pathway RIG-I Signaling Pathway Positive Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Response To Estrogen Suppression Of Viral Release By Host Innate Immune Response Positive Regulation Of DNA-templated Transcription Regulation Of Viral Entry Into Host Cell Host-mediated Suppression Of Symbiont Invasion Defense Response To Virus Protein K48-linked Ubiquitination Antiviral Innate Immune Response Cellular Response To Leukemia Inhibitory Factor	Negative Regulation Of Transcription By RNA Polymerase II Branching Involved In Blood Vessel Morphogenesis Vasculogenesis In Utero Embryonic Development Neuron Migration Extraocular Skeletal Muscle Development Outflow Tract Morphogenesis Atrioventricular Valve Development Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Pulmonary Myocardium Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Determination Of Left/right Symmetry Heart Development Skeletal Muscle Tissue Development Positive Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Animal Organ Morphogenesis Wnt Signaling Pathway Subthalamic Nucleus Development Hypothalamus Cell Migration Pituitary Gland Development Lung Development Regulation Of Cell Migration Embryonic Camera-type Eye Development Embryonic Hindlimb Morphogenesis Hair Cell Differentiation Vascular Associated Smooth Muscle Cell Differentiation Deltoid Tuberosity Development Regulation Of Cell Population Proliferation Odontogenesis Camera-type Eye Development Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Spleen Development Embryonic Digestive Tract Morphogenesis System Development Cardiac Muscle Tissue Development Cardiac Muscle Cell Differentiation Atrial Cardiac Muscle Tissue Morphogenesis Ventricular Cardiac Muscle Cell Development Digestive System Development Somatotropin Secreting Cell Differentiation Prolactin Secreting Cell Differentiation Ventricular Septum Morphogenesis Left Lung Morphogenesis Pulmonary Vein Morphogenesis Superior Vena Cava Morphogenesis Embryonic Heart Tube Left/right Pattern Formation Endodermal Digestive Tract Morphogenesis Iris Morphogenesis Cell Proliferation Involved In Outflow Tract Morphogenesis Left/right Axis Specification
Pathways		ISG15 antiviral mechanism DDX58/IFIH1-mediated induction of interferon-alpha/beta Termination of translesion DNA synthesis Ovarian tumor domain proteases Interferon gamma signaling TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses Evasion by RSV of host interferon responses RSV-host interactions PKR-mediated signaling Modulation of host responses by IFN-stimulated genes	TFAP2 (AP-2) family regulates transcription of other transcription factors
Drugs
Diseases			Axenfeld-Rieger syndrome (ARS)
GWAS		Height ( 18391951) Lean body mass ( 28552196)	Appendectomy ( 30392061) Atrial fibrillation ( 19597492 33990960 30061737 29892015 29290336 28416822 28416818 20173747 22544366) Atrial fibrillation/atrial flutter ( 17603472) Cardioembolic stroke (CCS and TOAST classification) ( 32047268) Cardioembolic stroke (CCS or TOAST classification) ( 32047268) Cardioembolic stroke (CCSc classification) ( 32047268) Cardioembolic stroke (CCSp classification) ( 32047268) Cardioembolic stroke (TOAST classification) ( 32047268) Cognitive decline rate in late mild cognitive impairment ( 26252872) Early onset atrial fibrillation ( 28460022) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits (multivariate) ( 32602732) Glaucoma (primary open-angle) ( 33627673) Heart failure ( 31919418) Incident atrial fibrillation ( 28416818) Intraocular pressure ( 29235454) Ischemic stroke ( 24262325 26708676) Ischemic stroke (cardioembolic) ( 26708676 27068588) Lung cancer ( 28604730) Prevalent atrial fibrillation ( 28416818) Sick sinus syndrome ( 33580673) Smoking status (heavy vs never) ( 26423011) Stroke (ischemic) ( 23041239)
Interacting Genes		77 interacting genes: AMFR APC CASP7 CEBPA CHKA CRK DDX3X DICER1 EIF4G3 ERCC2 ERG ESR1 G3BP1 G3BP2 GABARAP GABARAPL1 GABARAPL2 GATA1 GRIK2 LINC00955 MAP1LC3A MAP1LC3B MAP1LC3C MAP3K13 MEIS2 MIR1-1 MIR155 MIR16-2 MIR19B2 MIR205 MIR206 MIR21 MIR221 MIR25 MIR29A MIR29B1 MIR34A MIR363 MIR7-1 MIR92A1 MIR92A2 MIR98 MIRLET7A1 MIRLET7A3 MTA1 OTUB2 PAX2 PIK3R1 PITX2 PLAAT4 PTEN RBCK1 RIPK3 RNF31 SFN SLC26A4-AS1 STK11 STK38 SUMO2 TFG TRAF6 TRIM8 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2J2 UBE2L3 UBE2L6 UBE2N UBE2V1 USP15 USP39 YWHAQ ZBTB7A ZNF24	36 interacting genes: ATN1 CTNNB1 CYSRT1 DAZAP2 DYNLT1 HDAC1 HERC5 HEY1 HOXA1 KAT5 KRT34 KRTAP15-1 KRTAP19-5 KRTAP19-7 KRTAP3-3 KRTAP6-1 KRTAP7-1 LEF1 OIP5 PDLIM1 PFDN5 POU2AF1 PROP1 PSMB4 RBPMS SPMIP9 TINAGL1 TLE5 TRAF1 TRIB3 TRIM25 UFSP1 VGLL3 WWOX ZNF34 ZNHIT3
Entrez ID		7706	5308
HPRD ID		02711	03328
Ensembl ID		ENSG00000121060	ENSG00000164093
Uniprot IDs		Q14258	Q99697
PDB IDs		4CFG 4LTB 5EYA 5FER 5NT1 5NT2 6FLM 6FLN	2L7F 2L7M 2LKX
Enriched GO Terms of Interacting Partners?		Post-transcriptional Gene Silencing RISC Complex MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Post-transcriptional Regulation Of Gene Expression Ubiquitin Conjugating Enzyme Activity Negative Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Cellular Response To Nitrogen Starvation MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Ubiquitin Protein Ligase Binding Regulation Of Protein Metabolic Process Phosphatidylethanolamine Binding Protein Polyubiquitination Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction MRNA 3'-UTR Binding Cellular Response To Stress Negative Regulation Of Gene Expression Post-translational Protein Modification Response To Stress Regulation Of Primary Metabolic Process Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Protein Modification Process Positive Regulation Of Metabolic Process Regulation Of Signaling Regulation Of Cell Communication Negative Regulation Of Translation Positive Regulation Of Protein Polyubiquitination Ubiquitin-protein Transferase Activity Negative Regulation Of Cell Population Proliferation Positive Regulation Of Protein Ubiquitination Regulation Of RNA Metabolic Process Positive Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Cell Motility Negative Regulation Of Protein Metabolic Process Protein Modification By Small Protein Conjugation Negative Regulation Of Locomotion	Transcription Coactivator Activity Intermediate Filament Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Transcription Regulator Complex Fungiform Papilla Formation Positive Regulation Of RNA Metabolic Process Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Hair Follicle Placode Formation Regulation Of Wnt Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Transcription Corepressor Activity Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Odontoblast Differentiation Positive Regulation Of Neuroepithelial Cell Differentiation Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Transcription Corepressor Binding RNA Polymerase II Transcription Regulator Complex Regulation Of Odontoblast Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Beta-catenin-TCF Complex Maintenance Of Cell Polarity Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Binding Epithelial To Mesenchymal Transition Positive Regulation Of Biosynthetic Process Regulation Of Neurogenesis Positive Regulation Of Transcription By RNA Polymerase II Cytoplasmic Stress Granule Negative Regulation Of Nucleobase-containing Compound Metabolic Process Odontogenesis Positive Regulation Of Macromolecule Metabolic Process Protein Binding Mesenchymal Cell Differentiation Host-mediated Perturbation Of Symbiont Process
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