TRIM25 and STK38

Number of citations of the paper that reports this interaction (PMID 16884686)
17

Data Source:
BioGRID (pull down)

		TRIM25	STK38
Gene Name		tripartite motif containing 25	serine/threonine kinase 38
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol	Nucleus Cytoplasm MLL5-L Complex
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Zinc Ion Binding Acid-amino Acid Ligase Activity Poly(A) RNA Binding	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Mitogen-activated Protein Kinase Kinase Kinase Binding
	Biological Process	Viral Process Protein Ubiquitination Cytokine-mediated Signaling Pathway Negative Regulation Of Type I Interferon Production Response To Vitamin D Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Estrogen Innate Immune Response Regulation Of Viral Entry Into Host Cell Negative Regulation Of Viral Entry Into Host Cell Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Regulation Of Viral Release From Host Cell Negative Regulation Of Viral Release From Host Cell	Cellular Protein Modification Process Protein Phosphorylation Intracellular Signal Transduction Negative Regulation Of MAP Kinase Activity
Pathways		Negative regulators of RIG-I/MDA5 signaling ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Antiviral mechanism by IFN-stimulated genes Interferon gamma signaling RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Innate Immune System
Drugs
Diseases
GWAS		Height ( 18391951)
Protein-Protein Interactions		27 interactors: AMFR DDX58 ERCC2 ESR1 GATA1 GRIK2 MEIS2 OTUB2 PITX2 RARRES3 RBCK1 RNF31 SFN STK38 TFG TRAF6 TRIM8 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2J2 UBE2L6 UBE2N USP15 USP39 ZNF24	8 interactors: CALM1 CTDP1 HERC5 MOB2 S100B TRIM25 YWHAB YWHAZ
Entrez ID		7706	11329
HPRD ID		02711	09511
Ensembl ID		ENSG00000121060	ENSG00000112079
Uniprot IDs		Q14258	Q15208
PDB IDs			1PSB
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Cellular Macromolecule Catabolic Process Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of I-kappaB Kinase/NF-kappaB Signaling Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Response To Organic Substance Activation Of Innate Immune Response Proteolysis Immune Response-regulating Signaling Pathway Toll-like Receptor 4 Signaling Pathway Cellular Protein Modification Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Innate Immune Response Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein K48-linked Ubiquitination Toll-like Receptor Signaling Pathway Immune System Process Catabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Innate Immune Response Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Protein Metabolic Process Signaling Positive Regulation Of Immune Response Positive Regulation Of Immune System Process Proteasomal Protein Catabolic Process Cell Communication Response To Stimulus Cellular Response To Stimulus Regulation Of Immune System Process TRIF-dependent Toll-like Receptor Signaling Pathway Signal Transduction Cellular Metabolic Process Negative Regulation Of Gene Expression MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Transcription, DNA-templated Innate Immune Response Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Response To Organic Substance	Immune Response Defense Response Innate Immune Response Immune System Process Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Type I Interferon Production Response To Hormone Positive Regulation Of Mitochondrion Organization Response To Stress Regulation Of Protein Phosphorylation Regulation Of Intracellular Transport Response To Steroid Hormone Regulation Of Mitochondrion Organization Positive Regulation Of Signal Transduction Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Phosphorylation Regulation Of Type I Interferon Production Response To Organic Substance Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Dephosphorylation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cell Death Regulation Of Signal Transduction Regulation Of Viral Process Response To Glucocorticoid Defense Response To Virus Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Skeletal Muscle Cell Differentiation Golgi Reassembly Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Response To Corticosteroid Positive Regulation Of Protein Phosphorylation Positive Regulation Of Transport Regulation Of Signaling Regulation Of Protein Kinase Activity Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of High Voltage-gated Calcium Channel Activity Intrinsic Apoptotic Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Platelet Activation Response To Fibroblast Growth Factor Regulation Of Kinase Activity Response To External Stimulus Negative Regulation Of Protein Dephosphorylation Histamine Secretion By Mast Cell
Tagcloud ?		accelerates amf autocrine catalyzes cooperates cooperative dhfr e4 erad gauges gp78 illustrated insight isomerase ligase mechanistic motility pgi phosphoglucose polyubiquitylation round steady tripartite ub ubiquitin ubiquitylates ubiquitylation uncovers vital	asymmetric axon axons cascade depend dynein establishment evolutionarily invertebrates kinases mechanistically morphogenesis ndr ndr1 ndr2 par3 pard3 perform phosphorylating polarity polarization polarized polarizing rassf5 reinforcing ser383 specification supernumerary
Tagcloud (Difference) ?		accelerates amf autocrine catalyzes cooperates cooperative dhfr e4 erad gauges gp78 illustrated insight isomerase ligase mechanistic motility pgi phosphoglucose polyubiquitylation round steady tripartite ub ubiquitin ubiquitylates ubiquitylation uncovers vital	asymmetric axon axons cascade depend dynein establishment evolutionarily invertebrates kinases mechanistically morphogenesis ndr ndr1 ndr2 par3 pard3 perform phosphorylating polarity polarization polarized polarizing rassf5 reinforcing ser383 specification supernumerary
Tagcloud (Intersection) ?