TYK2 and IFNAR2

Number of citations of the paper that reports this interaction (PMID 12960323)
10

Data Source:
HPRD (in vitro)

		TYK2	IFNAR2
Gene Name		tyrosine kinase 2	interferon (alpha, beta and omega) receptor 2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Cytoskeleton Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Growth Hormone Receptor Binding Protein Binding ATP Binding Type 1 Angiotensin Receptor Binding	Type I Interferon Receptor Activity Protein Binding Protein Kinase Binding Type I Interferon Binding
	Biological Process	Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Migration Cytokine-mediated Signaling Pathway Cell Differentiation Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Proliferation Innate Immune Response Type I Interferon Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway	Regulation Of Transcription From RNA Polymerase II Promoter Cell Surface Receptor Signaling Pathway JAK-STAT Cascade Cell Proliferation Response To Virus Cytokine-mediated Signaling Pathway Response To Interferon-alpha Type I Interferon Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway
Pathways		Signaling by GPCR Signaling by FGFR in disease FCERI mediated MAPK activation Signaling by EGFRvIII in Cancer Signaling by SCF-KIT SHC1 events in ERBB2 signaling Toll Like Receptor TLR1:TLR2 Cascade DAP12 signaling Toll Like Receptor 5 (TLR5) Cascade Gastrin-CREB signalling pathway via PKC and MAPK MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade SOS-mediated signalling SHC-mediated signalling Signaling by PDGF DAP12 interactions Regulation of IFNA signaling TRIF-mediated TLR3/TLR4 signaling SHC-related events triggered by IGF1R ERK1 activation GRB2 events in EGFR signaling Signaling by ERBB4 ERK1 activation Toll Like Receptor 2 (TLR2) Cascade Signaling by ERBB2 Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling Signaling by VEGF Downstream signal transduction Signalling to RAS Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Interleukin-2 signaling Frs2-mediated activation Signaling by Leptin Signalling to ERKs Prolonged ERK activation events Axon guidance ERK activation IRS-mediated signalling Toll Like Receptor 7/8 (TLR7/8) Cascade Interleukin-6 signaling IGF1R signaling cascade Toll Like Receptor TLR6:TLR2 Cascade VEGFA-VEGFR2 Pathway IRS-related events triggered by IGF1R Activated TLR4 signalling MyD88 cascade initiated on plasma membrane VEGFR2 mediated cell proliferation GRB2 events in ERBB2 signaling ERK activation Downstream signaling of activated FGFR MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Interferon alpha/beta signaling NCAM signaling for neurite out-growth Signalling to p38 via RIT and RIN RAF/MAP kinase cascade Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade SOS-mediated signalling MAP kinase activation in TLR cascade SHC-mediated signalling Interferon Signaling IRS-related events Cytokine Signaling in Immune system Signaling by Ligand-Responsive EGFR Variants in Cancer SHC-related events NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer MyD88-independent cascade ERK2 activation Signaling by FGFR ARMS-mediated activation Toll-Like Receptors Cascades SHC1 events in EGFR signaling Toll Like Receptor 10 (TLR10) Cascade FRS2-mediated cascade IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) ERK2 activation
Drugs			Peginterferon alfa-2a Interferon alfa-n1 Interferon alfa-n3 Peginterferon alfa-2b Interferon Alfa-2a, Recombinant Interferon beta-1a Interferon beta-1b Interferon alfacon-1 Interferon Alfa-2b, Recombinant
Diseases
GWAS		Crohn's disease ( 21102463) Inflammatory bowel disease ( 23128233) Multiple sclerosis ( 21833088) Psoriasis ( 20953190) Type 1 diabetes ( 19966805) Type 1 diabetes autoantibodies ( 21829393)	Crohn's disease ( 23128233)
Protein-Protein Interactions		36 interactors: CBL COPS5 CRKL DNM2 EIF2AK2 FHL3 FYN GHR GNB2L1 HNRNPK IFNAR1 IFNAR2 IL13RA1 IL6ST IRS1 IRS2 JAK1 JAKMIP1 KHDRBS2 KRT40 LYN PDGFRB PIK3R1 PLAUR PRMT5 PTAFR PTPN1 PTPN6 PTPRC STAM2 STAT1 STAT2 TK1 TRAF4 VAV1 XRCC5	14 interactors: GNB2L1 IFNA2 IFNA5 IFNA8 IFNAR1 IFNB1 JAK1 PPP1R3B PRKCB STAT1 STAT2 STAT3 TYK2 USP18
Entrez ID		7297	3455
HPRD ID		01490	03850
Ensembl ID		ENSG00000105397	ENSG00000159110
Uniprot IDs		P29597	P48551 Q9BUA0
PDB IDs		3LXN 3LXP 3NYX 3NZ0 3ZON 4GFO 4GIH 4GII 4GJ2 4GJ3 4GVJ	1N6U 1N6V 2HYM 2KZ1 2LAG 3S8W 3S9D 3SE3 3SE4
Enriched GO Terms of Interacting Partners?		JAK-STAT Cascade Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Innate Immune Response Cellular Response To Organic Substance Regulation Of Immune Response Response To Growth Hormone Regulation Of Immune System Process JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Response To Organic Substance Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cytokine-mediated Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Signaling Defense Response Regulation Of Signal Transduction Regulation Of Type I Interferon-mediated Signaling Pathway Immune Response Cell Surface Receptor Signaling Pathway Immune System Process Signal Transduction Intracellular Signal Transduction Cytokine-mediated Signaling Pathway Regulation Of Kinase Activity Signaling Cell Communication Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Phosphorylation Cellular Response To Stimulus Response To Cytokine Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Type I Interferon Positive Regulation Of Cell Activation Cellular Response To Peptide Hormone Stimulus Cellular Response To Cytokine Stimulus Cellular Response To Peptide Regulation Of Intracellular Signal Transduction Regulation Of Phosphorus Metabolic Process Positive Regulation Of Intracellular Signal Transduction Immune Response-regulating Signaling Pathway Positive Regulation Of Signal Transduction Phosphatidylinositol-mediated Signaling Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Innate Immune Response Regulation Of Lymphocyte Activation Viral Process Fibroblast Growth Factor Receptor Signaling Pathway Response To Stimulus	Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of Cytokine-mediated Signaling Pathway Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Type I Interferon Regulation Of Innate Immune Response Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Response To Cytokine Regulation Of Immune Response Innate Immune Response Defense Response To Virus Regulation Of Immune System Process Cellular Response To Organic Substance Defense Response Regulation Of Signal Transduction Regulation Of Signaling Response To Virus Response To Organic Substance Immune Response Immune System Process Cell Surface Receptor Signaling Pathway Response To Stress Response To Exogenous DsRNA JAK-STAT Cascade Response To Other Organism Response To DsRNA Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Response To Biotic Stimulus Regulation Of MHC Class I Biosynthetic Process Natural Killer Cell Activation Involved In Immune Response Negative Regulation Of T-helper 2 Cell Cytokine Production Signal Transduction B Cell Activation Signaling B Cell Proliferation Regulation Of Cellular Amino Acid Metabolic Process Cell Communication Lymphocyte Activation Negative Regulation Of T Cell Cytokine Production Blood Coagulation Hemostasis Natural Killer Cell Activation Leukocyte Activation Regulation Of Cellular Ketone Metabolic Process T Cell Activation Involved In Immune Response Cellular Response To Stimulus Negative Regulation Of Viral Process Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Body Fluid Levels
Tagcloud ?		3t3 carboxyl coimmunoprecipitated directed f442a functionally gh ghr heretofore hmw immunoblotting immunologically immunoprecipitation independently jak1 jak2 jak3 janus kd member mr physically preadipocytes referred signalling step terminus tyrosine whose	aberration aberrations algorithms cgh characterised cin coca confirms crc custom deleted deletions driver fmcr gained gains hybridisation kcnma1 microsatellite mss nfkbia oncogenes prdm16 rassf3 rpa3 scna silico tns1
Tagcloud (Difference) ?		3t3 carboxyl coimmunoprecipitated directed f442a functionally gh ghr heretofore hmw immunoblotting immunologically immunoprecipitation independently jak1 jak2 jak3 janus kd member mr physically preadipocytes referred signalling step terminus tyrosine whose	aberration aberrations algorithms cgh characterised cin coca confirms crc custom deleted deletions driver fmcr gained gains hybridisation kcnma1 microsatellite mss nfkbia oncogenes prdm16 rassf3 rpa3 scna silico tns1
Tagcloud (Intersection) ?