TYK2 and JAK1

Number of citations of the paper that reports this interaction (PubMedID 7589562)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		TYK2	JAK1
Description		tyrosine kinase 2	Janus kinase 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane Extrinsic Component Of Plasma Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Interleukin-12 Receptor Complex Receptor Complex Extracellular Exosome Interleukin-23 Receptor Complex	Nucleus Cytoplasm Endosome Cytosol Plasma Membrane Focal Adhesion Cytoplasmic Side Of Plasma Membrane Endomembrane System Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Receptor Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Growth Hormone Receptor Binding Protein Binding ATP Binding Kinase Activity Transferase Activity	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Growth Hormone Receptor Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Phosphatase Binding Ubiquitin Protein Ligase Binding CCR5 Chemokine Receptor Binding Metal Ion Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Immune Response Cell Surface Receptor Signaling Pathway Via JAK-STAT Cell Population Proliferation Cytokine-mediated Signaling Pathway Regulation Of Cell-cell Adhesion Cell Differentiation Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Natural Killer Cell Proliferation Intracellular Signal Transduction Interleukin-12-mediated Signaling Pathway Interleukin-23-mediated Signaling Pathway Type III Interferon-mediated Signaling Pathway Positive Regulation Of T Cell Proliferation Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Alpha-beta T Cell Activation Positive Regulation Of NK T Cell Proliferation Type II Interferon-mediated Signaling Pathway Type I Interferon-mediated Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Cellular Response To Virus Interleukin-10-mediated Signaling Pathway Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of T-helper 17 Type Immune Response	Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Cell Surface Receptor Signaling Pathway Via JAK-STAT Cytokine-mediated Signaling Pathway Regulation Of Cell-cell Adhesion Cell Differentiation Positive Regulation Of Homotypic Cell-cell Adhesion Intracellular Signal Transduction Interleukin-15-mediated Signaling Pathway Interleukin-4-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway Interleukin-9-mediated Signaling Pathway Interleukin-11-mediated Signaling Pathway Type III Interferon-mediated Signaling Pathway Response To Antibiotic Regulation Of Multicellular Organismal Process Type II Interferon-mediated Signaling Pathway Type I Interferon-mediated Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Interleukin-6-mediated Signaling Pathway T-helper 17 Cell Lineage Commitment Cellular Response To Virus Cellular Response To Interleukin-7 Interleukin-10-mediated Signaling Pathway Protein Localization To Cell-cell Junction Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Sprouting Angiogenesis
Pathways		Interleukin-6 signaling Interleukin-6 signaling MAPK3 (ERK1) activation MAPK1 (ERK2) activation Other interleukin signaling Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling IL-6-type cytokine receptor ligand interactions Interleukin-20 family signaling Interleukin-35 Signalling Interleukin-12 signaling Interleukin-12 signaling Interleukin-23 signaling Interleukin-23 signaling Interleukin-27 signaling Interleukin-27 signaling Interferon alpha/beta signaling Regulation of IFNA/IFNB signaling Regulation of IFNA/IFNB signaling Signaling by CSF3 (G-CSF) Signaling by CSF3 (G-CSF) Potential therapeutics for SARS Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling SARS-CoV-2 activates/modulates innate and adaptive immune responses Signaling by ALK fusions and activated point mutants Evasion by RSV of host interferon responses	Interleukin-6 signaling Interleukin-6 signaling MAPK3 (ERK1) activation MAPK1 (ERK2) activation ISG15 antiviral mechanism Interleukin-7 signaling Interleukin-7 signaling Other interleukin signaling RAF/MAP kinase cascade Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling IL-6-type cytokine receptor ligand interactions Interferon gamma signaling Regulation of IFNG signaling Regulation of IFNG signaling Interleukin-20 family signaling Interleukin-15 signaling Interleukin-15 signaling Interleukin-35 Signalling Interleukin-9 signaling Interleukin-2 signaling Interleukin-12 signaling Interleukin-12 signaling Interleukin-27 signaling Interleukin-27 signaling Interleukin-21 signaling Interferon alpha/beta signaling Interleukin receptor SHC signaling Regulation of IFNA/IFNB signaling Regulation of IFNA/IFNB signaling Signaling by CSF3 (G-CSF) Signaling by CSF3 (G-CSF) Potential therapeutics for SARS Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling SARS-CoV-2 activates/modulates innate and adaptive immune responses IFNG signaling activates MAPKs Evasion by RSV of host interferon responses PD-L1(CD274) glycosylation and translocation to plasma membrane
Drugs		2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one Ruxolitinib Tofacitinib Baricitinib Fostamatinib Abrocitinib Deucravacitinib	Myricetin 2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one Ruxolitinib Tofacitinib Baricitinib Fostamatinib Fedratinib Filgotinib Abrocitinib Upadacitinib Pralsetinib Ivarmacitinib
Diseases		Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
GWAS		Ankylosing spondylitis ( 23749187) Autoimmune thyroid disease ( 32581359) Autoimmune traits (pleiotropy) ( 30572963) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) COVID-19 (critical illness vs population) ( 33307546) Crohn's disease ( 21102463 28067908) Inflammatory bowel disease ( 28067908 23128233) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 32888494) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 24076602 31604244 21833088) Neutrophil percentage of white cells ( 32888494 27863252) Pediatric autoimmune diseases ( 26301688) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494) Primary biliary cholangitis ( 26394269) Primary biliary cirrhosis ( 22961000) Psoriasis ( 20953190 23143594) Psoriasis vulgaris ( 26626624) Psoriatic arthritis ( 26626624) Rheumatoid arthritis ( 23143596 30423114 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Sarcoidosis ( 26051272) Systemic lupus erythematosus ( 27399966 33272962 26502338 28714469) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655) Type 1 diabetes ( 21829393 19966805 32005708 25751624) Voxel-wise structural brain imaging measurements in Alzheimer’s disease ( 30584014)	Appendicular lean mass ( 33097823) Autoimmune thyroid disease ( 32581359) Bevacizumab-induced proteinuria ( 34616010) Cognitive function in longevity ( 33607172) Core binding factor acute myeloid leukemia ( 27903959) Eosinophil count ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Liver enzyme levels (alkaline phosphatase) ( 33972514) Medication use (thyroid preparations) ( 31015401) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244) Neutrophil percentage of granulocytes ( 27863252) Plasma anti-thyroglobulin levels ( 29678681) Platelet count ( 32888494) Plateletcrit ( 32888494) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		44 interacting genes: CBL COPS5 CRKL CYSRT1 DNM2 EIF2AK2 FHL3 FYN GHR GOLGA6L9 HNRNPK IFNAR1 IFNAR2 IL13RA1 IL6ST IRS1 IRS2 JAK1 JAKMIP1 KHDRBS2 KHDRBS3 KRT31 KRT40 KRTAP6-3 LYN PDGFRB PIK3R1 PLAUR PRDM5 PRMT5 PTAFR PTPN1 PTPN6 PTPRC RACK1 SOCS1 STAM2 STAT1 STAT2 TK1 TP53BP2 TRAF4 VAV1 XRCC5	77 interacting genes: ABL1 AGTR1 BRCA1 BTK CCR1 CCR5 CISH CSF2RB CSF3R CXCR4 EIF2AK2 ELP2 ERBB2 FER FES GAB1 GHR GRB2 H3-4 IFNAR2 IFNGR1 IGF1R IL10RA IL21R IL2RB IL2RG IL3RA IL4R IL5RA IL6ST IL7R IL9R INPP5D INSR IRS1 IRS2 JAK2 JAK3 JAKMIP1 MDK OSMR PDGFRA PDGFRB PIK3R1 PLA2G4A PLAUR PLCG2 PRKCZ PRMT5 PTK2B PTPN11 PTPN2 PTPN6 PTPRC RACK1 RAF1 SH2B2 SHB SOCS1 SOCS2 SOCS3 STAM STAM2 STAT1 STAT2 STAT3 STAT5A STAT6 STUB1 SYK TEC TNFRSF1A TOP1 TSHR TTC3 TYK2 USP6
Entrez ID		7297	3716
HPRD ID		01490	00992
Ensembl ID		ENSG00000105397	ENSG00000162434
Uniprot IDs		A0A8V8TN50 A0A8V8TPX5 H0YCT7 H0YE24 P29597	A0A8V8TPQ9 P23458 Q6P669
PDB IDs		3LXN 3LXP 3NYX 3NZ0 3ZON 4GFO 4GIH 4GII 4GJ2 4GJ3 4GVJ 4OLI 4PO6 4PY1 4WOV 5C01 5C03 5F1Z 5F20 5TKD 5WAL 6AAM 6DBK 6DBM 6NSL 6NZE 6NZF 6NZH 6NZP 6NZQ 6NZR 6OVA 6VNS 6VNV 6VNX 6VNY 6X8F 6X8G 7AX4 7K7O 7K7Q 7UYR 7UYS 7UYT 7UYU 8EXN 8EYC 8S98 8S99 8S9A 8TB5 8TB6	3EYG 3EYH 4E4L 4E4N 4E5W 4EHZ 4EI4 4FK6 4GS0 4I5C 4IVB 4IVC 4IVD 4K6Z 4K77 4L00 4L01 5E1E 5HX8 5IXD 5IXI 5KHW 5KHX 5L04 5WO4 6AAH 6BBU 6C7Y 6DBN 6ELR 6GGH 6HZU 6N77 6N78 6N79 6N7A 6N7B 6N7C 6N7D 6RSB 6RSC 6RSD 6RSE 6RSH 6SM8 6SMB 6TPE 6TPF 6W8L 8EXJ 8S85
Enriched GO Terms of Interacting Partners?		Cytokine-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Positive Regulation Of Signal Transduction Phosphotyrosine Residue Binding Growth Hormone Receptor Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Programmed Cell Death Positive Regulation Of Multicellular Organismal Process SH3 Domain Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Receptor Signaling Pathway Via JAK-STAT Growth Hormone Receptor Signaling Pathway Via JAK-STAT Receptor Complex SH2 Domain Binding Response To External Biotic Stimulus Cytokine Binding Phosphatidylinositol 3-kinase Binding Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Enzyme Binding Response To Peptide Hormone Regulation Of Signaling Regulation Of Cell Communication Enzyme-linked Receptor Protein Signaling Pathway Signal Transduction Cytosol Regulation Of MAPK Cascade Cellular Response To Insulin Stimulus Cellular Response To Platelet-derived Growth Factor Stimulus Regulation Of Cell Adhesion Type I Interferon-mediated Signaling Pathway Response To Other Organism Response To Insulin Insulin Receptor Binding Positive Regulation Of Cell-cell Adhesion Response To Platelet-derived Growth Factor Regulation Of Defense Response Protein Kinase Binding Phosphatidylinositol 3-kinase Activator Activity Cellular Response To Peptide Hormone Stimulus Lymphocyte Proliferation Ephrin Receptor Binding Mononuclear Cell Proliferation Regulation Of Macromolecule Biosynthetic Process	Cytokine-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Multicellular Organismal Process Regulation Of Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell Population Proliferation Cytokine Receptor Activity Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Population Proliferation Regulation Of Cell Activation Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Hemopoiesis Regulation Of Cell Differentiation Protein Tyrosine Kinase Activity Regulation Of Signal Transduction Regulation Of Developmental Process Regulation Of Immune System Process Peptidyl-tyrosine Phosphorylation Positive Regulation Of Lymphocyte Activation Regulation Of Cell Development Positive Regulation Of Cell Activation Regulation Of Lymphocyte Activation Positive Regulation Of Immune System Process Immune System Process Cell Activation Receptor Complex Positive Regulation Of Signal Transduction Plasma Membrane Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of Developmental Process Regulation Of Signaling Regulation Of Cell Communication External Side Of Plasma Membrane Regulation Of Lymphocyte Differentiation Regulation Of Multicellular Organismal Development Growth Hormone Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Phosphorylation Leukocyte Activation Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Cell Communication Positive Regulation Of Signaling Intracellular Signal Transduction Regulation Of T Cell Activation Protein Phosphorylation Lymphocyte Activation Regulation Of Cell Adhesion
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