TYK2 and JAK1

  • Number of citations of the paper that reports this interaction (PMID 8702790)
  • 34
  • Data Source:
  • BioGRID (affinity chromatography technology)
  • HPRD (in vitro, in vivo)

TYK2

JAK1

Gene Name tyrosine kinase 2 Janus kinase 1
Image
Gene Ontology Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions 36 interactors: CBL COPS5 CRKL DNM2 EIF2AK2 FHL3 FYN GHR GNB2L1 HNRNPK IFNAR1 IFNAR2 IL13RA1 IL6ST IRS1 IRS2 JAK1 JAKMIP1 KHDRBS2 KRT40 LYN PDGFRB PIK3R1 PLAUR PRMT5 PTAFR PTPN1 PTPN6 PTPRC STAM2 STAT1 STAT2 TK1 TRAF4 VAV1 XRCC5 69 interactors: ABL1 BRCA1 BTK CCR1 CCR5 CSF2RB CSF3R CXCR4 EIF2AK2 ELP2 ERBB2 FER FES GHR GNB2L1 GRB2 HIST3H3 IFNAR2 IFNGR1 IGF1R IL10RA IL21R IL2RB IL2RG IL3RA IL4R IL5RA IL6ST IL7R IL9R INPP5D INSR IRS1 IRS2 JAK3 JAKMIP1 MDK OSMR PDGFRA PDGFRB PIK3R1 PLA2G4A PLAUR PLCG2 PRKCZ PRMT5 PTK2B PTPN11 PTPN2 PTPN6 PTPRC RAF1 SH2B2 SHB SOCS1 SOCS3 STAM STAM2 STAT1 STAT2 STAT3 STAT5A STAT6 SYK TEC TNFRSF1A TOP1 TSHR TYK2
Entrez ID 7297 3716
HPRD ID 01490 00992
Ensembl ID ENSG00000105397 ENSG00000162434
Uniprot IDs P29597 P23458
PDB IDs 3LXN 3LXP 3NYX 3NZ0 3ZON 4GFO 4GIH 4GII 4GJ2 4GJ3 4GVJ 3EYG 3EYH 4E4L 4E4N 4E5W 4EHZ 4EI4 4FK6 4GS0 4I5C 4IVB 4IVC 4IVD 4K6Z 4K77 4L00 4L01
Enriched GO Terms of Interacting Partners?
Tagcloud ?
3t3  carboxyl  coimmunoprecipitated  directed  f442a  functionally  gh  ghr  heretofore  hmw  immunoblotting  immunologically  immunoprecipitation  independently  jak1  jak2  jak3  janus  kd  member  mr  physically  preadipocytes  referred  signalling  step  terminus  tyrosine  whose 
2c4  assign  b10  b3  b9  cd2  complementation  crossed  crosses  crossing  facs  gbp  guanylate  hlas  hybrids  ifn  oas  oligoadenylate  pairwise  permitted  responsiveness  restore  rounds  submitted  synthetase  u3  u4  unresponsive  unresponsiveness 
Tagcloud (Difference) ?
3t3  carboxyl  coimmunoprecipitated  directed  f442a  functionally  gh  ghr  heretofore  hmw  immunoblotting  immunologically  immunoprecipitation  independently  jak2  jak3  janus  kd  member  mr  physically  preadipocytes  referred  signalling  step  terminus  tyrosine  whose 
2c4  assign  b10  b3  b9  cd2  complementation  crossed  crosses  crossing  facs  gbp  guanylate  hlas  hybrids  ifn  oas  oligoadenylate  pairwise  permitted  responsiveness  restore  rounds  submitted  synthetase  u3  u4  unresponsive  unresponsiveness 
Tagcloud (Intersection) ?
jak1