TYK2 and PRMT5

Number of citations of the paper that reports this interaction (PubMedID 10531356)
0

Data Source:
HPRD (in vitro)

		TYK2	PRMT5
Description		tyrosine kinase 2	protein arginine methyltransferase 5
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane Extrinsic Component Of Plasma Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Interleukin-12 Receptor Complex Receptor Complex Extracellular Exosome Interleukin-23 Receptor Complex	Chromatin Nucleus Nucleoplasm Chromosome Cytoplasm Golgi Apparatus Cytosol Protein-containing Complex Methylosome Histone Methyltransferase Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Growth Hormone Receptor Binding Protein Binding ATP Binding Kinase Activity Transferase Activity	P53 Binding Transcription Corepressor Activity Protein Binding Methyltransferase Activity Methyl-CpG Binding Histone Arginine N-methyltransferase Activity Protein-arginine N-methyltransferase Activity Transferase Activity Protein-arginine Omega-N Symmetric Methyltransferase Activity Histone Methyltransferase Activity Identical Protein Binding Ribonucleoprotein Complex Binding Histone H4R3 Methyltransferase Activity Protein-containing Complex Binding Protein Heterodimerization Activity E-box Binding Histone H3 Methyltransferase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Immune Response Cell Surface Receptor Signaling Pathway Via JAK-STAT Cell Population Proliferation Cytokine-mediated Signaling Pathway Regulation Of Cell-cell Adhesion Cell Differentiation Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Natural Killer Cell Proliferation Intracellular Signal Transduction Interleukin-12-mediated Signaling Pathway Interleukin-23-mediated Signaling Pathway Type III Interferon-mediated Signaling Pathway Positive Regulation Of T Cell Proliferation Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Alpha-beta T Cell Activation Positive Regulation Of NK T Cell Proliferation Type II Interferon-mediated Signaling Pathway Type I Interferon-mediated Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Cellular Response To Virus Interleukin-10-mediated Signaling Pathway Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of T-helper 17 Type Immune Response	Spliceosomal SnRNP Assembly Chromatin Organization Chromatin Remodeling DNA-templated Transcription Termination Regulation Of DNA-templated Transcription Regulation Of Mitotic Nuclear Division Regulation Of Gene Expression Peptidyl-arginine Methylation Methylation Circadian Regulation Of Gene Expression Peptidyl-arginine N-methylation Endothelial Cell Activation Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Negative Regulation Of Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of MRNA Splicing, Via Spliceosome Rhythmic Process Positive Regulation Of Oligodendrocyte Differentiation Regulation Of ERK1 And ERK2 Cascade Golgi Ribbon Formation Liver Regeneration Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway
Pathways		Interleukin-6 signaling Interleukin-6 signaling MAPK3 (ERK1) activation MAPK1 (ERK2) activation Other interleukin signaling Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling IL-6-type cytokine receptor ligand interactions Interleukin-20 family signaling Interleukin-35 Signalling Interleukin-12 signaling Interleukin-12 signaling Interleukin-23 signaling Interleukin-23 signaling Interleukin-27 signaling Interleukin-27 signaling Interferon alpha/beta signaling Regulation of IFNA/IFNB signaling Regulation of IFNA/IFNB signaling Signaling by CSF3 (G-CSF) Signaling by CSF3 (G-CSF) Potential therapeutics for SARS Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling SARS-CoV-2 activates/modulates innate and adaptive immune responses Signaling by ALK fusions and activated point mutants Evasion by RSV of host interferon responses	snRNP Assembly RMTs methylate histone arginines Regulation of TP53 Activity through Methylation
Drugs		2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one Ruxolitinib Tofacitinib Baricitinib Fostamatinib Abrocitinib Deucravacitinib
Diseases		Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
GWAS		Ankylosing spondylitis ( 23749187) Autoimmune thyroid disease ( 32581359) Autoimmune traits (pleiotropy) ( 30572963) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) COVID-19 (critical illness vs population) ( 33307546) Crohn's disease ( 21102463 28067908) Inflammatory bowel disease ( 28067908 23128233) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 32888494) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 24076602 31604244 21833088) Neutrophil percentage of white cells ( 32888494 27863252) Pediatric autoimmune diseases ( 26301688) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494) Primary biliary cholangitis ( 26394269) Primary biliary cirrhosis ( 22961000) Psoriasis ( 20953190 23143594) Psoriasis vulgaris ( 26626624) Psoriatic arthritis ( 26626624) Rheumatoid arthritis ( 23143596 30423114 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Sarcoidosis ( 26051272) Systemic lupus erythematosus ( 27399966 33272962 26502338 28714469) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655) Type 1 diabetes ( 21829393 19966805 32005708 25751624) Voxel-wise structural brain imaging measurements in Alzheimer’s disease ( 30584014)	Cortical amyloid beta load ( 29860282) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993)
Interacting Genes		44 interacting genes: CBL COPS5 CRKL CYSRT1 DNM2 EIF2AK2 FHL3 FYN GHR GOLGA6L9 HNRNPK IFNAR1 IFNAR2 IL13RA1 IL6ST IRS1 IRS2 JAK1 JAKMIP1 KHDRBS2 KHDRBS3 KRT31 KRT40 KRTAP6-3 LYN PDGFRB PIK3R1 PLAUR PRDM5 PRMT5 PTAFR PTPN1 PTPN6 PTPRC RACK1 SOCS1 STAM2 STAT1 STAT2 TK1 TP53BP2 TRAF4 VAV1 XRCC5	93 interacting genes: ACE2 AIRIM ARGLU1 CACNB2 CALU CAPN1 CDC37 CDK19 CDK8 CDYL2 CLK1 CLK3 CLNS1A COPRS CTDP1 DIO3 DNMT3A DRC4 DUSP14 EIF4A1 EIF4A3 ELOA EPHB6 EZH2 FAM47E FAM76B G3BP2 GLI1 GRHL3 GTPBP2 H2AC20 H2AC4 H3-4 H3-5 H4C1 H4C16 HOXC4 ILF3 ING5 JAK1 JAK2 JAK3 KANK2 LDHAL6B LENG8 LNX1 LUC7L MAGEB2 MBP MCRS1 MEF2D MXI1 MYOD1 MYOG NCL NELFCD NTAQ1 OLA1 PDCD4 PDGFRA PHYHIP POLR2A PRPF38A RBFOX2 RBM23 RNF4 RSRP1 SIN3A SLU7 SNRNP70 SNRPB SNRPD1 SNRPD3 SPAG8 SREBF1 SSTR1 SUPT5H TRIB3 TRIM54 TYK2 UBC UBE3A WDR5 WDR77 YWHAG YWHAQ YWHAZ ZDHHC17 ZMYND19 ZNF2 ZNF224 ZNF436 ZUP1
Entrez ID		7297	10419
HPRD ID		01490	04955
Ensembl ID		ENSG00000105397	ENSG00000100462
Uniprot IDs		A0A8V8TN50 A0A8V8TPX5 H0YCT7 H0YE24 P29597	B4DV00 O14744
PDB IDs		3LXN 3LXP 3NYX 3NZ0 3ZON 4GFO 4GIH 4GII 4GJ2 4GJ3 4GVJ 4OLI 4PO6 4PY1 4WOV 5C01 5C03 5F1Z 5F20 5TKD 5WAL 6AAM 6DBK 6DBM 6NSL 6NZE 6NZF 6NZH 6NZP 6NZQ 6NZR 6OVA 6VNS 6VNV 6VNX 6VNY 6X8F 6X8G 7AX4 7K7O 7K7Q 7UYR 7UYS 7UYT 7UYU 8EXN 8EYC 8S98 8S99 8S9A 8TB5 8TB6	4GQB 4X60 4X61 4X63 5C9Z 5EMJ 5EMK 5EML 5EMM 5FA5 6CKC 6K1S 6RLL 6RLQ 6UGH 6UXX 6UXY 6V0N 6V0O 6V0P 7BO7 7BOC 7KIB 7KIC 7KID 7L1G 7M05 7MX7 7MXA 7MXC 7MXG 7MXN 7S0U 7S1P 7S1Q 7S1R 7S1S 7SER 7SES 7U30 7UOH 7UY1 7UYF 7ZUP 7ZUQ 7ZUU 7ZUY 7ZV2 7ZVL 7ZVU 8CSG 8CTB 8CYI 8G1U 8VEO 8VET 8VEU 8VEW 8VEX 8VEY 8X6L 9C10 9DOD 9E3A 9E3B 9E3C 9EYU 9EYV 9EYW 9EYX 9MGL 9MGM 9MGN 9MGP 9MGQ 9MGR 9N3N 9N3O 9N3P 9N3Q 9N3R
Enriched GO Terms of Interacting Partners?		Cytokine-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Positive Regulation Of Signal Transduction Phosphotyrosine Residue Binding Growth Hormone Receptor Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Programmed Cell Death Positive Regulation Of Multicellular Organismal Process SH3 Domain Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Receptor Signaling Pathway Via JAK-STAT Growth Hormone Receptor Signaling Pathway Via JAK-STAT Receptor Complex SH2 Domain Binding Response To External Biotic Stimulus Cytokine Binding Phosphatidylinositol 3-kinase Binding Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Enzyme Binding Response To Peptide Hormone Regulation Of Signaling Regulation Of Cell Communication Enzyme-linked Receptor Protein Signaling Pathway Signal Transduction Cytosol Regulation Of MAPK Cascade Cellular Response To Insulin Stimulus Cellular Response To Platelet-derived Growth Factor Stimulus Regulation Of Cell Adhesion Type I Interferon-mediated Signaling Pathway Response To Other Organism Response To Insulin Insulin Receptor Binding Positive Regulation Of Cell-cell Adhesion Response To Platelet-derived Growth Factor Regulation Of Defense Response Protein Kinase Binding Phosphatidylinositol 3-kinase Activator Activity Cellular Response To Peptide Hormone Stimulus Lymphocyte Proliferation Ephrin Receptor Binding Mononuclear Cell Proliferation Regulation Of Macromolecule Biosynthetic Process	Nucleus Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Methylosome RNA Binding Regulation Of RNA Splicing Regulation Of Metabolic Process U1 SnRNP Binding U1 SnRNP Regulation Of MRNA Splicing, Via Spliceosome Growth Hormone Receptor Binding Regulation Of Transcription By RNA Polymerase II Protein Binding Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane RNA Splicing Spliceosomal Complex Regulation Of MRNA Processing MRNA Metabolic Process Growth Hormone Receptor Signaling Pathway Via JAK-STAT MRNA Splicing, Via Spliceosome Small Nuclear Ribonucleoprotein Complex Regulation Of MRNA Metabolic Process RNA Splicing, Via Transesterification Reactions PICln-Sm Protein Complex Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of RNA Splicing Spliceosomal SnRNP Assembly Chromosome MRNA Processing Protein Tyrosine Kinase Activity Structural Constituent Of Chromatin Growth Hormone Receptor Signaling Pathway 7-methylguanosine Cap Hypermethylation Protein Localization To Chromatin Protein-RNA Complex Assembly Extrinsic Component Of Plasma Membrane Protein Modification Process RNA Metabolic Process Positive Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process U4 SnRNP Negative Regulation Of Macromolecule Biosynthetic Process
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