TXNRD1 and TXNIP

Number of citations of the paper that reports this interaction (PMID 9207062)
59

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		TXNRD1	TXNIP
Gene Name		thioredoxin reductase 1	thioredoxin interacting protein
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Nucleolus Cytosol Extracellular Vesicular Exosome	Nucleus Cytoplasm Mitochondrial Intermembrane Space Cytosol
	Molecular Function	Thioredoxin-disulfide Reductase Activity Protein Binding Electron Carrier Activity Protein Disulfide Oxidoreductase Activity Flavin Adenine Dinucleotide Binding	Enzyme Inhibitor Activity Protein Binding Ubiquitin Protein Ligase Binding
	Biological Process	Response To Reactive Oxygen Species Signal Transduction Nucleobase-containing Small Molecule Interconversion Cellular Lipid Metabolic Process Small Molecule Metabolic Process Cell Redox Homeostasis Nucleobase-containing Small Molecule Metabolic Process Oxidation-reduction Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Protein Import Into Nucleus Cell Cycle Response To Mechanical Stimulus Response To Glucose Keratinocyte Differentiation Response To Estradiol Response To Progesterone Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Cell Proliferation Response To Drug Response To Hydrogen Peroxide Positive Regulation Of Apoptotic Process Negative Regulation Of Catalytic Activity Innate Immune Response Platelet-derived Growth Factor Receptor Signaling Pathway Response To Calcium Ion Negative Regulation Of Cell Division Cellular Response To Tumor Cell
Pathways		PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Uptake and actions of bacterial toxins Metabolism of lipids and lipoproteins Detoxification of Reactive Oxygen Species Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Metabolism of nucleotides Synthesis and interconversion of nucleotide di- and triphosphates Uptake and function of diphtheria toxin	The NLRP3 inflammasome Inflammasomes Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Innate Immune System
Drugs		Arsenic trioxide Nadph Dihydro-Nicotinamide-Adenine-Dinucleotidephosphate Flavin-Adenine Dinucleotide Spermidine Fotemustine
Diseases
GWAS
Protein-Protein Interactions		8 interactors: DMRTC2 FOXO1 GLRX2 POU2F1 POU2F2 PPP1R16A TXNDC17 TXNIP	14 interactors: DDIT4 ECD FHL1 HDAC1 HDAC3 ITCH KPNA2 PRKAA1 SCEL SMURF2 TXN TXNRD1 ZBTB16 ZBTB32
Entrez ID		7296	10628
HPRD ID		03068	05964
Ensembl ID		ENSG00000198431	ENSG00000117289
Uniprot IDs		B7Z1F4 B7Z2S5 B7Z904 E7EW10 Q16881	Q9H3M7
PDB IDs		1W1C 2CFY 2J3N 2ZZ0 2ZZB 2ZZC 3QFA 3QFB	4GEI 4GEJ
Enriched GO Terms of Interacting Partners?		Response To Reactive Oxygen Species Cell Differentiation Transcription, DNA-templated RNA Biosynthetic Process Response To Oxidative Stress Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Response To Inorganic Substance Regulation Of RNA Metabolic Process Cellular Response To Tumor Cell Positive Regulation Of Histone H3-K9 Dimethylation Positive Regulation Of Histone H3-K9 Trimethylation Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Immunoglobulin Secretion Involved In Immune Response DNA Protection Response To Hydrogen Peroxide RNA Metabolic Process Developmental Process Nitrogen Compound Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Response To Temperature Stimulus Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Cellular Response To Extracellular Stimulus Response To Tumor Cell Immunoglobulin Secretion Olfactory Placode Formation Cellular Response To Cold Spermatid Nucleus Elongation Regulation Of Gluconeogenesis By Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Hyperoxia Response To Abiotic Stimulus Negative Regulation Of Transcription, DNA-templated Lens Induction In Camera-type Eye Positive Regulation Of Histone H3-K9 Methylation Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Response To Organic Substance Regulation Of Energy Homeostasis Positive Regulation Of Cellular Metabolic Process Cellular Response To Nitric Oxide Response To Redox State Response To Nitric Oxide	Negative Regulation Of Cellular Metabolic Process Regulation Of Glycolytic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Regulation Of TOR Signaling Regulation Of Nitrogen Compound Metabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Cell Death Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Signal Transduction Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Signaling Nucleobase-containing Compound Metabolic Process Nucleobase-containing Small Molecule Interconversion Cell Proliferation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Gene Expression Notch Signaling Pathway Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Intracellular Signal Transduction Regulation Of Carbohydrate Metabolic Process Histone H4 Deacetylation Transcription From RNA Polymerase II Promoter Negative Regulation Of Cell Cycle Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cell Cycle RNA Metabolic Process Negative Regulation Of JNK Cascade Regulation Of Transcription, DNA-templated Negative Regulation Of Cell Death Nitrogen Compound Metabolic Process Negative Regulation Of TOR Signaling Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Response To Reactive Oxygen Species Histone H3 Deacetylation Negative Regulation Of Stress-activated MAPK Cascade Histone H3-K9 Modification Regulation Of RNA Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Response To Stress Gene Expression Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Neurotrophin Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor
Tagcloud ?		bring btg1 cyr61 dcs e7 epha1 hla idc idcs igfbp3 igsf6 il8 kpna7 mdc mdcs mrps11 ncr3 nfkb1a nfkbia padre pgf pidc pulsed pulsing rad21 sema6a srgn trem2 tubal3	another arrest better br breast bt474 causes corresponding g1 indicated inversely little marker microarray noncancerous os p27 plays previous prognostic r regarding sk strong taken thioredoxin tissue transfection validated
Tagcloud (Difference) ?		bring btg1 cyr61 dcs e7 epha1 hla idc idcs igfbp3 igsf6 il8 kpna7 mdc mdcs mrps11 ncr3 nfkb1a nfkbia padre pgf pidc pulsed pulsing rad21 sema6a srgn trem2 tubal3	another arrest better br breast bt474 causes corresponding g1 indicated inversely little marker microarray noncancerous os p27 plays previous prognostic r regarding sk strong taken thioredoxin tissue transfection validated
Tagcloud (Intersection) ?