TXNRD1 and POU2F1

Number of citations of the paper that reports this interaction (PMID 10383413)
9

Data Source:
BioGRID (pull down)

		TXNRD1	POU2F1
Gene Name		thioredoxin reductase 1	POU class 2 homeobox 1
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Nucleolus Cytosol Extracellular Vesicular Exosome	Nucleus Nucleoplasm Transcription Factor Complex Intracellular Membrane-bounded Organelle
	Molecular Function	Thioredoxin-disulfide Reductase Activity Protein Binding Electron Carrier Activity Protein Disulfide Oxidoreductase Activity Flavin Adenine Dinucleotide Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding
	Biological Process	Response To Reactive Oxygen Species Signal Transduction Nucleobase-containing Small Molecule Interconversion Cellular Lipid Metabolic Process Small Molecule Metabolic Process Cell Redox Homeostasis Nucleobase-containing Small Molecule Metabolic Process Oxidation-reduction Process	Transcription From RNA Polymerase III Promoter Gene Expression Olfactory Placode Formation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Lens Induction In Camera-type Eye
Pathways		PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Uptake and actions of bacterial toxins Metabolism of lipids and lipoproteins Detoxification of Reactive Oxygen Species Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Metabolism of nucleotides Synthesis and interconversion of nucleotide di- and triphosphates Uptake and function of diphtheria toxin	RNA Polymerase III Transcription RNA Polymerase III Transcription Initiation RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase III Abortive And Retractive Initiation
Drugs		Arsenic trioxide Nadph Dihydro-Nicotinamide-Adenine-Dinucleotidephosphate Flavin-Adenine Dinucleotide Spermidine Fotemustine
Diseases
GWAS			Liver enzyme levels ( 18940312)
Protein-Protein Interactions		8 interactors: DMRTC2 FOXO1 GLRX2 POU2F1 POU2F2 PPP1R16A TXNDC17 TXNIP	50 interactors: AES APP AR BARD1 BRCA1 CEBPE CREB1 EPRS ESR1 FDXR HCFC1 HMGA1 HMGB2 HNF1A HOXB13 HOXC9 IRF9 LIFR MNAT1 MSX1 NCOR2 NFYA NPAT NR3C1 PARP1 PBX1 PGR PKNOX1 PLK3 POGZ POU2AF1 PRKACA PRKDC RARA RELA RXRA SNAPC4 SOX2 SP1 SP4 STAT5A STAT5B TBP THRA TLE4 TLX2 TNF TXNRD1 VDR XRCC6
Entrez ID		7296	5451
HPRD ID		03068	01250
Ensembl ID		ENSG00000198431	ENSG00000143190
Uniprot IDs		B7Z1F4 B7Z2S5 B7Z904 E7EW10 Q16881	J3KP77 P14859
PDB IDs		1W1C 2CFY 2J3N 2ZZ0 2ZZB 2ZZC 3QFA 3QFB	1CQT 1E3O 1GT0 1HF0 1O4X 1OCT 1POG 1POU
Enriched GO Terms of Interacting Partners?		Response To Reactive Oxygen Species Cell Differentiation Transcription, DNA-templated RNA Biosynthetic Process Response To Oxidative Stress Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Response To Inorganic Substance Regulation Of RNA Metabolic Process Cellular Response To Tumor Cell Positive Regulation Of Histone H3-K9 Dimethylation Positive Regulation Of Histone H3-K9 Trimethylation Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Immunoglobulin Secretion Involved In Immune Response DNA Protection Response To Hydrogen Peroxide RNA Metabolic Process Developmental Process Nitrogen Compound Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Response To Temperature Stimulus Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Cellular Response To Extracellular Stimulus Response To Tumor Cell Immunoglobulin Secretion Olfactory Placode Formation Cellular Response To Cold Spermatid Nucleus Elongation Regulation Of Gluconeogenesis By Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Hyperoxia Response To Abiotic Stimulus Negative Regulation Of Transcription, DNA-templated Lens Induction In Camera-type Eye Positive Regulation Of Histone H3-K9 Methylation Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Response To Organic Substance Regulation Of Energy Homeostasis Positive Regulation Of Cellular Metabolic Process Cellular Response To Nitric Oxide Response To Redox State Response To Nitric Oxide	Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Gene Expression RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Gland Development Negative Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Organ Development Response To Organic Substance Negative Regulation Of Cellular Metabolic Process Response To Hormone DNA-templated Transcription, Initiation Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Cellular Response To Organic Substance Response To Steroid Hormone Organ Morphogenesis Reproductive Process Hormone-mediated Signaling Pathway Anatomical Structure Morphogenesis Intracellular Receptor Signaling Pathway Multicellular Organismal Development System Development
Tagcloud ?		bring btg1 cyr61 dcs e7 epha1 hla idc idcs igfbp3 igsf6 il8 kpna7 mdc mdcs mrps11 ncr3 nfkb1a nfkbia padre pgf pidc pulsed pulsing rad21 sema6a srgn trem2 tubal3	build built compendium connected controlling databases delineate deoxyribonuclease encode experimentally footprinting gata3 hnf1b hypersensitivity klf4 locations matrices motifs orthologs rarb runx2 rxra silico smad3 sp1 sp3 umod upstream uromodulin
Tagcloud (Difference) ?		bring btg1 cyr61 dcs e7 epha1 hla idc idcs igfbp3 igsf6 il8 kpna7 mdc mdcs mrps11 ncr3 nfkb1a nfkbia padre pgf pidc pulsed pulsing rad21 sema6a srgn trem2 tubal3	build built compendium connected controlling databases delineate deoxyribonuclease encode experimentally footprinting gata3 hnf1b hypersensitivity klf4 locations matrices motifs orthologs rarb runx2 rxra silico smad3 sp1 sp3 umod upstream uromodulin
Tagcloud (Intersection) ?