TXNRD1 and DMRTC2

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		TXNRD1	DMRTC2
Gene Name		thioredoxin reductase 1	DMRT-like family C2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Nucleolus Cytosol Extracellular Vesicular Exosome	XY Body Nucleus
	Molecular Function	Thioredoxin-disulfide Reductase Activity Protein Binding Electron Carrier Activity Protein Disulfide Oxidoreductase Activity Flavin Adenine Dinucleotide Binding	Core Promoter Proximal Region Sequence-specific DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Response To Reactive Oxygen Species Signal Transduction Nucleobase-containing Small Molecule Interconversion Cellular Lipid Metabolic Process Small Molecule Metabolic Process Cell Redox Homeostasis Nucleobase-containing Small Molecule Metabolic Process Oxidation-reduction Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Male Meiosis I Spermatid Nucleus Elongation Sex Differentiation Positive Regulation Of Histone H3-K9 Dimethylation Positive Regulation Of Histone H3-K9 Trimethylation
Pathways		PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Uptake and actions of bacterial toxins Metabolism of lipids and lipoproteins Detoxification of Reactive Oxygen Species Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Metabolism of nucleotides Synthesis and interconversion of nucleotide di- and triphosphates Uptake and function of diphtheria toxin
Drugs		Arsenic trioxide Nadph Dihydro-Nicotinamide-Adenine-Dinucleotidephosphate Flavin-Adenine Dinucleotide Spermidine Fotemustine
Diseases
GWAS
Protein-Protein Interactions		8 interactors: DMRTC2 FOXO1 GLRX2 POU2F1 POU2F2 PPP1R16A TXNDC17 TXNIP	2 interactors: IRF9 TXNRD1
Entrez ID		7296	63946
HPRD ID		03068	16829
Ensembl ID		ENSG00000198431	ENSG00000142025
Uniprot IDs		B7Z1F4 B7Z2S5 B7Z904 E7EW10 Q16881	Q8IXT2
PDB IDs		1W1C 2CFY 2J3N 2ZZ0 2ZZB 2ZZC 3QFA 3QFB
Enriched GO Terms of Interacting Partners?		Response To Reactive Oxygen Species Cell Differentiation Transcription, DNA-templated RNA Biosynthetic Process Response To Oxidative Stress Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Response To Inorganic Substance Regulation Of RNA Metabolic Process Cellular Response To Tumor Cell Positive Regulation Of Histone H3-K9 Dimethylation Positive Regulation Of Histone H3-K9 Trimethylation Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Immunoglobulin Secretion Involved In Immune Response DNA Protection Response To Hydrogen Peroxide RNA Metabolic Process Developmental Process Nitrogen Compound Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Response To Temperature Stimulus Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Cellular Response To Extracellular Stimulus Response To Tumor Cell Immunoglobulin Secretion Olfactory Placode Formation Cellular Response To Cold Spermatid Nucleus Elongation Regulation Of Gluconeogenesis By Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Hyperoxia Response To Abiotic Stimulus Negative Regulation Of Transcription, DNA-templated Lens Induction In Camera-type Eye Positive Regulation Of Histone H3-K9 Methylation Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Response To Organic Substance Regulation Of Energy Homeostasis Positive Regulation Of Cellular Metabolic Process Cellular Response To Nitric Oxide Response To Redox State Response To Nitric Oxide	Detoxification Of Mercury Ion Type I Interferon Biosynthetic Process Type I Interferon Production Nucleobase-containing Small Molecule Interconversion Response To Mercury Ion Cytokine Biosynthetic Process Cytokine Metabolic Process
Tagcloud ?		bring btg1 cyr61 dcs e7 epha1 hla idc idcs igfbp3 igsf6 il8 kpna7 mdc mdcs mrps11 ncr3 nfkb1a nfkbia padre pgf pidc pulsed pulsing rad21 sema6a srgn trem2 tubal3
Tagcloud (Difference) ?		bring btg1 cyr61 dcs e7 epha1 hla idc idcs igfbp3 igsf6 il8 kpna7 mdc mdcs mrps11 ncr3 nfkb1a nfkbia padre pgf pidc pulsed pulsing rad21 sema6a srgn trem2 tubal3
Tagcloud (Intersection) ?