TXNRD1 and THRA

Number of citations of the paper that reports this interaction (PubMedID 15199063)
0

Data Source:
BioGRID (pull down)

		TXNRD1	THRA
Description		thioredoxin reductase 1	thyroid hormone receptor alpha
Image
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Extracellular Exosome	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Thioredoxin-disulfide Reductase (NADPH) Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On A Sulfur Group Of Donors, NAD(P) As Acceptor Identical Protein Binding NADPH Peroxidase Activity Flavin Adenine Dinucleotide Binding FAD Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding TBP-class Protein Binding Protein Domain Specific Binding Chromatin DNA Binding Sequence-specific DNA Binding Protein-containing Complex Binding Metal Ion Binding Thyroid Hormone Binding General Transcription Initiation Factor Binding
	Biological Process	Mesoderm Formation Signal Transduction Gastrulation Cell Population Proliferation Cell Redox Homeostasis Cellular Oxidant Detoxification	Negative Regulation Of Transcription By RNA Polymerase II Cartilage Condensation Ossification Thyroid Hormone Receptor Signaling Pathway Regulation Of Thyroid Hormone Receptor Signaling Pathway Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Learning Or Memory Regulation Of Heart Contraction Female Courtship Behavior Response To Cold Hormone-mediated Signaling Pathway Animal Organ Morphogenesis Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Cell Differentiation Erythrocyte Differentiation Thyroid Gland Development Regulation Of Myeloid Cell Apoptotic Process MRNA Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Positive Regulation Of Female Receptivity Positive Regulation Of Transcription By RNA Polymerase II Retinoic Acid Receptor Signaling Pathway Regulation Of Lipid Catabolic Process Type I Pneumocyte Differentiation Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of DNA-templated Transcription Initiation
Pathways		PPARA activates gene expression Metabolism of ingested H2SeO4 and H2SeO3 into H2Se Detoxification of Reactive Oxygen Species Interconversion of nucleotide di- and triphosphates Metabolism of ingested MeSeO2H into MeSeH Uptake and function of diphtheria toxin TP53 Regulates Metabolic Genes NFE2L2 regulating anti-oxidant/detoxification enzymes	Nuclear Receptor transcription pathway
Drugs		Arsenic trioxide NADPH Flavin adenine dinucleotide Spermidine Fotemustine Motexafin gadolinium PX-12	Liothyronine Levothyroxine Dextrothyroxine Amiodarone Liotrix KB-141 Dronedarone Eprotirome NRP409 Thyroid, porcine
Diseases
GWAS		Blood protein levels ( 30072576) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Hypertrophic cardiomyopathy (sarcomere positive) ( 33495597) Logical memory (delayed recall) in normal cognition ( 29274321) Toenail selenium levels ( 25343990)	Asthma ( 31619474) Bipolar disorder ( 31043756) Chronic obstructive pulmonary disease ( 30804561) Pancreatic ductal adenocarcinoma ( 30541042) White blood cell count ( 21738480)
Interacting Genes		12 interacting genes: CEBPA DMRTC2 ESR1 ESR2 GLRX2 LINC01554 POU2F1 POU2F2 PPP1R16A THRA TXNDC17 TXNIP	68 interacting genes: AKAP13 AMOT AMOTL2 ARID5A BTG1 BUB3 C1D CCND1 CD160 CDK7 CEP76 CLIC1 COPS2 CREB1 CREBBP CUL1 DAP3 ESR1 FOXJ1 FUS GRIP1 GTF2B HDAC2 HDAC3 ITGB3BP L3MBTL3 MED1 MED21 MED25 MEF2A MEOX2 MTNR1B NCOA1 NCOA2 NCOA6 NCOR1 NCOR2 NR0B2 NR2F1 NRIP1 NSD1 OASL PML POU2F1 PRKAR1B PRKDC PTGES3 RANBP9 RGN RXRA RXRB RXRG SELENOP SLC16A2 SRC SUV39H1 SYAP1 TACC1 TBL1X TDG TRIM24 TRIM63 TRIP11 TXNRD1 UBE2I YWHAH YWHAQ ZBTB3
Entrez ID		7296	7067
HPRD ID		03068	07185
Ensembl ID		ENSG00000198431	ENSG00000126351
Uniprot IDs		B7Z2S5 Q16881	P10827 Q6FH41
PDB IDs		2CFY 2J3N 2ZZ0 2ZZB 2ZZC 3QFA 3QFB 7X1R	1NAV 2H77 2H79 3HZF 3ILZ 3JZB 4LNW 4LNX 7QDT 8RQO
Enriched GO Terms of Interacting Partners?		Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin DNA-binding Transcription Factor Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Nuclear Estrogen Receptor Activity Nuclear Receptor Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Estrogen Response Element Binding Nuclear Receptor-mediated Signaling Pathway Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Response To Estradiol Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Transcription Regulator Complex Estrogen Receptor Signaling Pathway Nuclear Steroid Receptor Activity Regulation Of Nucleobase-containing Compound Metabolic Process Hormone-mediated Signaling Pathway TBP-class Protein Binding Steroid Binding Negative Regulation Of RNA Metabolic Process DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Estradiol Stimulus Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Intracellular Receptor Signaling Pathway Transcription Cis-regulatory Region Binding RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of RNA Metabolic Process Arsenate Reductase (glutaredoxin) Activity Enzyme Inhibitor Activity Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Response To Vitamin B2 C/EBP Complex Regulation Of MiRNA Transcription Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Female Courtship Behavior Glutathione Disulfide Oxidoreductase Activity Regulation Of DNA-templated Transcription Initiation	Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Nuclear Retinoid X Receptor Binding Nuclear Receptor Binding Regulation Of Primary Metabolic Process Nuclear Retinoic Acid Receptor Binding Nucleoplasm Nuclear Thyroid Hormone Receptor Binding Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Nucleus Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Nuclear Receptor-mediated Signaling Pathway Negative Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Rhythmic Process Transcription Corepressor Activity Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Nuclear Estrogen Receptor Binding Positive Regulation Of Metabolic Process Intracellular Receptor Signaling Pathway Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Chromatin Binding Chromatin Transcription By RNA Polymerase II Hormone-mediated Signaling Pathway DNA-templated Transcription Transcription Coactivator Activity Intracellular Signal Transduction Transcription Coregulator Activity Transcription Regulator Complex
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