TXN and DYNLT1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		TXN	DYNLT1
Gene Name		thioredoxin	dynein, light chain, Tctex-type 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Extracellular Vesicular Exosome	Golgi Apparatus Spindle Cytoplasmic Dynein Complex Microtubule
	Molecular Function	Protein Binding Protein Disulfide Oxidoreductase Activity Peptide Disulfide Oxidoreductase Activity Poly(A) RNA Binding	Motor Activity Protein Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Reactive Oxygen Species Transcription, DNA-templated Glycerol Ether Metabolic Process Movement Of Cell Or Subcellular Component Signal Transduction Cell-cell Signaling Cell Proliferation Response To Radiation Nucleobase-containing Small Molecule Interconversion Activation Of Protein Kinase B Activity Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Protein Import Into Nucleus, Translocation Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of DNA Binding Small Molecule Metabolic Process Innate Immune Response Cell Redox Homeostasis Negative Regulation Of Protein Export From Nucleus Positive Regulation Of Protein Kinase B Signaling Nucleobase-containing Small Molecule Metabolic Process Oxidation-reduction Process Negative Regulation Of Hydrogen Peroxide-induced Cell Death	Establishment Of Mitotic Spindle Orientation Mitotic Nuclear Division Metabolic Process Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Intracellular Transport Of Viral Protein In Host Cell Regulation Of Rac GTPase Activity Viral Entry Into Host Cell Neuron Projection Morphogenesis Negative Regulation Of Neurogenesis Cell Division Regulation Of Cytoskeleton Organization Microtubule-dependent Intracellular Transport Of Viral Material Towards Nucleus
Pathways		The NLRP3 inflammasome Inflammasomes Oxidative Stress Induced Senescence Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Cellular Senescence Detoxification of Reactive Oxygen Species Metabolism of nucleotides Synthesis and interconversion of nucleotide di- and triphosphates Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		22 interactors: ACTN4 APEX1 CDKN1A COL1A1 COPS5 DNAJA1 DYNLT1 FST GFER GPRASP2 MAP3K5 MLH1 MYD88 NCF4 NFE2 NFKB1 NR3C1 SIAH1 TP53 TXNIP UCHL5 VIM	16 interactors: APP BAG3 BMPR2 DOC2A DOC2B DVL1 DVL2 DYNC1I1 HSPB9 PVR RAD21 SVIL TROAP TUBA3C TXN VDAC1
Entrez ID		7295	6993
HPRD ID		01761	15987
Ensembl ID		ENSG00000136810	ENSG00000146425
Uniprot IDs		H9ZYJ2 P10599	P63172
PDB IDs		1AIU 1AUC 1CQG 1CQH 1ERT 1ERU 1ERV 1ERW 1M7T 1MDI 1MDJ 1MDK 1TRS 1TRU 1TRV 1TRW 1W1C 1W1E 2HSH 2HXK 2IFQ 2IIY 3E3E 3KD0 3M9J 3M9K 3QFA 3QFB 3TRX 4TRX
Enriched GO Terms of Interacting Partners?		Regulation Of Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Apoptotic Process Regulation Of Cell Death Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Signal Transduction Cell Communication Response To Stress Response To Oxidative Stress Response To Stimulus Regulation Of Signaling Response To Abiotic Stimulus Response To Hydrogen Peroxide Signaling Immune System Process Cellular Response To Stimulus Positive Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Immune Response Cellular Response To Growth Factor Stimulus Positive Regulation Of Apoptotic Process Response To Growth Factor Regulation Of Cellular Process Apoptotic Process Regulation Of JNK Cascade Signal Transduction Programmed Cell Death Intrinsic Apoptotic Signaling Pathway Response To Organic Substance Cell Death Regulation Of Stress-activated MAPK Cascade Death Response To Reactive Oxygen Species Positive Regulation Of Cellular Metabolic Process Cellular Response To Stress Developmental Process Epithelium Development Intracellular Receptor Signaling Pathway Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Neuron Death Response To Mechanical Stimulus Cellular Response To Mechanical Stimulus Stress-induced Premature Senescence Anatomical Structure Development Negative Regulation Of Catalytic Activity Response To Inorganic Substance System Development Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway	Convergent Extension Involved In Neural Plate Elongation Collateral Sprouting Convergent Extension Involved In Organogenesis Neural Plate Morphogenesis Planar Cell Polarity Pathway Involved In Neural Tube Closure Regulation Of Establishment Of Planar Polarity Involved In Neural Tube Closure Neurotransmitter Secretion Convergent Extension Neural Plate Development Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Neurotransmitter Levels Cochlea Morphogenesis Neurotransmitter Transport Cell-cell Signaling Non-canonical Wnt Signaling Pathway Secretion By Cell Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Cellular Localization Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Cochlea Development Neuromuscular Junction Development Regulation Of Binding Regulation Of Calcium Ion-dependent Exocytosis Secretion Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Protein Metabolic Process Morphogenesis Of An Epithelial Sheet Regulation Of Phosphorylation Regulation Of Protein Kinase Activity Microtubule-based Process Regulation Of Kinase Activity Regulation Of Lung Blood Pressure Synaptic Growth At Neuromuscular Junction Negative Regulation Of Chondrocyte Proliferation Susceptibility To T Cell Mediated Cytotoxicity Developmental Cell Growth Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Canonical Wnt Signaling Pathway Regulation Of Cellular Amino Acid Metabolic Process Nervous System Development Inner Ear Morphogenesis Negative Regulation Of Vasoconstriction Collateral Sprouting In Absence Of Injury Regulation Of Embryonic Development Apoptotic Process Signaling Positive Regulation Of Canonical Wnt Signaling Pathway Ear Morphogenesis
Tagcloud ?		alphascreen ammp calnexin cndp2 combines hsp90aa1 hsp90b1 hspa1b hspa5 hspa9 identifier imbalance itraq nfhcc nonfibrotic nontumor p4hb pdia6 phosphoproteomics pointed proteomexchange proteomics proteostasis pxd001253 resident ser583 ubc unraveling vcp	1inq53a 250viqd 52gqvd adapter attempt capsid defective dynein hiv immunodeficiency integrase interaction kd ma motifs mutational p150glued particulate predicts proper q252a replication requirement reverse steps tctex transcriptase uncoating
Tagcloud (Difference) ?		alphascreen ammp calnexin cndp2 combines hsp90aa1 hsp90b1 hspa1b hspa5 hspa9 identifier imbalance itraq nfhcc nonfibrotic nontumor p4hb pdia6 phosphoproteomics pointed proteomexchange proteomics proteostasis pxd001253 resident ser583 ubc unraveling vcp	1inq53a 250viqd 52gqvd adapter attempt capsid defective dynein hiv immunodeficiency integrase interaction kd ma motifs mutational p150glued particulate predicts proper q252a replication requirement reverse steps tctex transcriptase uncoating
Tagcloud (Intersection) ?