DYNLT1 and KLK15

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		DYNLT1	KLK15
Name		dynein light chain Tctex-type 1	kallikrein related peptidase 15
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Golgi Apparatus Spindle Cytoskeleton Cytoplasmic Dynein Complex Microtubule Cytoplasmic Microtubule Dynein Complex Secretory Granule Lumen Host Cell Secretory Vesicle Ficolin-1-rich Granule Lumen	Extracellular Region Extracellular Space Secretory Granule
	Molecular Function	Protein Binding Identical Protein Binding Dynein Intermediate Chain Binding	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity
	Biological Process	Establishment Of Mitotic Spindle Orientation Microtubule-based Movement Nervous System Development Regulation Of G Protein-coupled Receptor Signaling Pathway Intracellular Transport Of Viral Protein In Host Cell Positive Regulation Of Intracellular Transport Symbiont Entry Into Host Cell Negative Regulation Of Neurogenesis Cell Division Microtubule-dependent Intracellular Transport Of Viral Material Towards Nucleus Transport Of Viral Material Towards Nucleus	Proteolysis Protein Maturation
Pathways		Neutrophil degranulation	None
GWAS		No GWAS studies recorded	Celiac disease ( 23936387 ) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189 ) Prostate-specific antigen levels ( 25434496 )
Novel Interactors		7 novel interactors: ACAT2 CRHBP ERO1A PRKN RPS6KA2 SYNJ2 TMEM143	None recorded
Interacting Genes		48 interacting genes: ACOX2 ACTN1 APP ARID4B BAG3 BMPR2 CCDC68 DDX54 DHX33 DNAJA2 DOC2A DOC2B DVL1 DVL2 DYNC1I1 DYNC1I2 FXR2 HAVCR1 HSPB7 HSPB9 ILF2 KIF2A KLK15 LNX1 NHSL2 NTAQ1 NUP153 NUP62 OLFM3 PELO PITX2 PSMA1 PTGES3L-AARSD1 PTH2R PVR RAD21 RBM14 RRAGA SDCBP SIRPA SVIL TCEANC TROAP TUBA3C TXN UXT VDAC1 XRN2	4 interacting genes: DYNLT1 HOOK2 KRTAP10-3 TRIP6
Entrez ID		6993	55554
HPRD ID		15987	07490
Ensembl ID		ENSG00000146425	ENSG00000174562
Uniprot IDs		P63172	A0A6B7HBY5 A0A6B7HEB8 M0R0D7 Q6UBM2 Q9H2R5
PDB IDs		5JPW 8J07 8PR0 8PR1 8PTK 8RGI	Not available
GO Terms Enriched among Interactors		Aggresome Chemical Synaptic Transmission Frizzled Binding Trans-synaptic Signaling Synaptic Signaling Synapse PTB Domain Binding Convergent Extension Involved In Neural Plate Elongation Microtubule-based Process Outflow Tract Morphogenesis Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cytoplasm Presynapse Regulation Of JNK Cascade Amyloid Fibril Formation Convergent Extension Involved In Organogenesis Regulation Of Spontaneous Synaptic Transmission Spindle Pole Convergent Extension Involved In Gastrulation Aggresome Assembly Spontaneous Neurotransmitter Secretion Synaptic Vesicle Exocytosis Positive Regulation Of Cellular Component Organization Transport Along Microtubule Vesicle-mediated Transport In Synapse Dynein Light Chain Binding Neurotransmitter Transport Positive Regulation Of Neuron Projection Arborization Neurotransmitter Secretion Protein-folding Chaperone Binding Cellular Response To Manganese Ion Regulated Exocytosis Regulation Of Exocytosis Centriolar Subdistal Appendage Inclusion Body Assembly Cytoskeleton-dependent Intracellular Transport Negative Regulation Of Transport Apoptotic Process Hsp70 Protein Binding Modulation Of Excitatory Postsynaptic Potential Positive Regulation Of Type 2 Mitophagy Cell-cell Signaling Microtubule-based Transport Programmed Cell Death Cell Death Microtubule Convergent Extension Calcium-dependent Activation Of Synaptic Vesicle Fusion Microtubule Motor Activity Response To Manganese Ion	Transport Of Viral Material Towards Nucleus Microtubule-dependent Intracellular Transport Of Viral Material Towards Nucleus Intracellular Transport Of Viral Protein In Host Cell Host Cell Microtubule Intracellular Transport Of Virus Cytoskeleton Secretory Vesicle Protein Localization To Perinuclear Region Of Cytoplasm FHF Complex Interleukin-1 Receptor Binding HOPS Complex Microtubule Cytoskeleton Organization Cytoplasmic Dynein Complex Nuclear Thyroid Hormone Receptor Binding Focal Adhesion Assembly Early Endosome To Late Endosome Transport Dynein Light Intermediate Chain Binding