TXN and NCF4

Number of citations of the paper that reports this interaction (PMID 10397171)
4

Data Source:
BioGRID (two hybrid)
HPRD (in vitro, two hybrid)

		TXN	NCF4
Gene Name		thioredoxin	neutrophil cytosolic factor 4, 40kDa
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Extracellular Vesicular Exosome	Cytosol Endosome Membrane Membrane Phagolysosome NADPH Oxidase Complex
	Molecular Function	Protein Binding Protein Disulfide Oxidoreductase Activity Peptide Disulfide Oxidoreductase Activity Poly(A) RNA Binding	Protein Binding Superoxide-generating NADPH Oxidase Activator Activity Phosphatidylinositol-3-phosphate Binding Protein Dimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Reactive Oxygen Species Transcription, DNA-templated Glycerol Ether Metabolic Process Movement Of Cell Or Subcellular Component Signal Transduction Cell-cell Signaling Cell Proliferation Response To Radiation Nucleobase-containing Small Molecule Interconversion Activation Of Protein Kinase B Activity Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Protein Import Into Nucleus, Translocation Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of DNA Binding Small Molecule Metabolic Process Innate Immune Response Cell Redox Homeostasis Negative Regulation Of Protein Export From Nucleus Positive Regulation Of Protein Kinase B Signaling Nucleobase-containing Small Molecule Metabolic Process Oxidation-reduction Process Negative Regulation Of Hydrogen Peroxide-induced Cell Death	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Immune Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Positive Regulation Of Catalytic Activity Vascular Endothelial Growth Factor Receptor Signaling Pathway Interaction With Host Oxidation-reduction Process Phagosome Maturation
Pathways		The NLRP3 inflammasome Inflammasomes Oxidative Stress Induced Senescence Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Cellular Senescence Detoxification of Reactive Oxygen Species Metabolism of nucleotides Synthesis and interconversion of nucleotide di- and triphosphates Innate Immune System	Signaling by VEGF Phagosomal maturation (early endosomal stage) Latent infection of Homo sapiens with Mycobacterium tuberculosis Class I MHC mediated antigen processing & presentation Antigen processing-Cross presentation VEGFA-VEGFR2 Pathway Cross-presentation of particulate exogenous antigens (phagosomes) Adaptive Immune System
Drugs
Diseases
GWAS			Atopic dermatitis ( 22197932)
Protein-Protein Interactions		22 interactors: ACTN4 APEX1 CDKN1A COL1A1 COPS5 DNAJA1 DYNLT1 FST GFER GPRASP2 MAP3K5 MLH1 MYD88 NCF4 NFE2 NFKB1 NR3C1 SIAH1 TP53 TXNIP UCHL5 VIM	10 interactors: CORO1A CYBA CYBB MSN NCF1 NCF2 PRKCD PRKDC TXN XRCC6
Entrez ID		7295	4689
HPRD ID		01761	03289
Ensembl ID		ENSG00000136810	ENSG00000100365
Uniprot IDs		H9ZYJ2 P10599	Q15080
PDB IDs		1AIU 1AUC 1CQG 1CQH 1ERT 1ERU 1ERV 1ERW 1M7T 1MDI 1MDJ 1MDK 1TRS 1TRU 1TRV 1TRW 1W1C 1W1E 2HSH 2HXK 2IFQ 2IIY 3E3E 3KD0 3M9J 3M9K 3QFA 3QFB 3TRX 4TRX	1H6H 1OEY 1W6X 1W70 1Z9Q 2DYB
Enriched GO Terms of Interacting Partners?		Regulation Of Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Apoptotic Process Regulation Of Cell Death Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Signal Transduction Cell Communication Response To Stress Response To Oxidative Stress Response To Stimulus Regulation Of Signaling Response To Abiotic Stimulus Response To Hydrogen Peroxide Signaling Immune System Process Cellular Response To Stimulus Positive Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Immune Response Cellular Response To Growth Factor Stimulus Positive Regulation Of Apoptotic Process Response To Growth Factor Regulation Of Cellular Process Apoptotic Process Regulation Of JNK Cascade Signal Transduction Programmed Cell Death Intrinsic Apoptotic Signaling Pathway Response To Organic Substance Cell Death Regulation Of Stress-activated MAPK Cascade Death Response To Reactive Oxygen Species Positive Regulation Of Cellular Metabolic Process Cellular Response To Stress Developmental Process Epithelium Development Intracellular Receptor Signaling Pathway Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Neuron Death Response To Mechanical Stimulus Cellular Response To Mechanical Stimulus Stress-induced Premature Senescence Anatomical Structure Development Negative Regulation Of Catalytic Activity Response To Inorganic Substance System Development Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway	Innate Immune Response Phagosome Maturation Respiratory Burst Superoxide Anion Generation Immune Response Immune System Process Defense Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Superoxide Metabolic Process Hydrogen Peroxide Biosynthetic Process Interaction With Host Reactive Oxygen Species Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Response To Stress Hydrogen Peroxide Metabolic Process Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Peptide Antigen Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Antigen Processing And Presentation Enzyme Linked Receptor Protein Signaling Pathway Response To Radiation Response To Ionizing Radiation Response To External Stimulus Double-strand Break Repair Via Nonhomologous End Joining Response To Abiotic Stimulus Organelle Organization V(D)J Recombination Cellular Response To Stimulus Regulation Of Ion Transport Positive Regulation Of Blood Pressure Homeostatic Process Signal Transduction Response To Gamma Radiation Regulation Of Cell Death Cellular Defense Response Cellular Response To Ionizing Radiation Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cell Communication Positive Regulation Of Phospholipid Scramblase Activity Smooth Muscle Hypertrophy Positive Regulation Of Glucosylceramide Catabolic Process Positive Regulation Of Sphingomyelin Catabolic Process Negative Regulation Of Glomerular Filtration By Angiotensin Telomere Maintenance Regulation Of Calcium Ion Transport Into Cytosol Response To Stimulus Positive Regulation Of Type I Interferon Production Cellular Response To Organic Substance
Tagcloud ?		alphascreen ammp calnexin cndp2 combines hsp90aa1 hsp90b1 hspa1b hspa5 hspa9 identifier imbalance itraq nfhcc nonfibrotic nontumor p4hb pdia6 phosphoproteomics pointed proteomexchange proteomics proteostasis pxd001253 resident ser583 ubc unraveling vcp	anion besides biopsies chl copy cyba cybb deleterious deletions downregulation exert hodgkin hybridisation lines lymphoma nadph ncf1 ncf2 oxidase phagocytic profiling progenitors proved quantify recurrent reed sternberg subsets superoxide
Tagcloud (Difference) ?		alphascreen ammp calnexin cndp2 combines hsp90aa1 hsp90b1 hspa1b hspa5 hspa9 identifier imbalance itraq nfhcc nonfibrotic nontumor p4hb pdia6 phosphoproteomics pointed proteomexchange proteomics proteostasis pxd001253 resident ser583 ubc unraveling vcp	anion besides biopsies chl copy cyba cybb deleterious deletions downregulation exert hodgkin hybridisation lines lymphoma nadph ncf1 ncf2 oxidase phagocytic profiling progenitors proved quantify recurrent reed sternberg subsets superoxide
Tagcloud (Intersection) ?