DYNLT1 and PTH2R

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DYNLT1	PTH2R
Description		dynein light chain Tctex-type 1	parathyroid hormone 2 receptor
Image
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Golgi Apparatus Spindle Cytoskeleton Cytoplasmic Dynein Complex Microtubule Cytoplasmic Microtubule Dynein Complex Secretory Granule Lumen Host Cell Secretory Vesicle Ficolin-1-rich Granule Lumen	Plasma Membrane Membrane
	Molecular Function	Protein Binding Identical Protein Binding Dynein Intermediate Chain Binding	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Parathyroid Hormone Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Peptide Hormone Binding
	Biological Process	Establishment Of Mitotic Spindle Orientation Microtubule-based Movement Nervous System Development Regulation Of G Protein-coupled Receptor Signaling Pathway Intracellular Transport Of Viral Protein In Host Cell Positive Regulation Of Intracellular Transport Symbiont Entry Into Host Cell Negative Regulation Of Neurogenesis Cell Division Microtubule-dependent Intracellular Transport Of Viral Material Towards Nucleus Transport Of Viral Material Towards Nucleus	Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis
Pathways		Neutrophil degranulation	Class B/2 (Secretin family receptors) G alpha (s) signalling events
Drugs			Parathyroid hormone
Diseases
GWAS			Amyotrophic lateral sclerosis (sporadic) ( 24529757) Anthropometric traits ( 30576415) Hip bone mineral density and total body fat mass (bivariate analysis) ( 32963334) Metabolite levels ( 23823483) Obsessive-compulsive disorder or autism spectrum disorder ( 28641744)
Interacting Genes		48 interacting genes: ACOX2 ACTN1 APP ARID4B BAG3 BMPR2 CCDC68 DDX54 DHX33 DNAJA2 DOC2A DOC2B DVL1 DVL2 DYNC1I1 DYNC1I2 FXR2 HAVCR1 HSPB7 HSPB9 ILF2 KIF2A KLK15 LNX1 NHSL2 NTAQ1 NUP153 NUP62 OLFM3 PELO PITX2 PSMA1 PTGES3L-AARSD1 PTH2R PVR RAD21 RBM14 RRAGA SDCBP SIRPA SVIL TCEANC TROAP TUBA3C TXN UXT VDAC1 XRN2	6 interacting genes: CALM1 DYNLT1 GRHPR HMG20A PTH PTH2
Entrez ID		6993	5746
HPRD ID		15987	03276
Ensembl ID		ENSG00000146425	ENSG00000144407
Uniprot IDs		P63172	B4DFN8 P49190
PDB IDs		5JPW 8J07 8PR0 8PR1 8PTK 8RGI	7F16
Enriched GO Terms of Interacting Partners?		Aggresome Chemical Synaptic Transmission Frizzled Binding Trans-synaptic Signaling Synaptic Signaling Synapse PTB Domain Binding Convergent Extension Involved In Neural Plate Elongation Microtubule-based Process Outflow Tract Morphogenesis Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cytoplasm Presynapse Regulation Of JNK Cascade Amyloid Fibril Formation Convergent Extension Involved In Organogenesis Regulation Of Spontaneous Synaptic Transmission Spindle Pole Convergent Extension Involved In Gastrulation Aggresome Assembly Spontaneous Neurotransmitter Secretion Synaptic Vesicle Exocytosis Positive Regulation Of Cellular Component Organization Transport Along Microtubule Vesicle-mediated Transport In Synapse Dynein Light Chain Binding Neurotransmitter Transport Positive Regulation Of Neuron Projection Arborization Neurotransmitter Secretion Protein-folding Chaperone Binding Cellular Response To Manganese Ion Regulated Exocytosis Regulation Of Exocytosis Centriolar Subdistal Appendage Inclusion Body Assembly Cytoskeleton-dependent Intracellular Transport Negative Regulation Of Transport Apoptotic Process Hsp70 Protein Binding Modulation Of Excitatory Postsynaptic Potential Positive Regulation Of Type 2 Mitophagy Cell-cell Signaling Microtubule-based Transport Programmed Cell Death Cell Death Microtubule Convergent Extension Calcium-dependent Activation Of Synaptic Vesicle Fusion Microtubule Motor Activity Response To Manganese Ion	Catalytic Complex Type 1 Parathyroid Hormone Receptor Binding Parathyroid Hormone Receptor Binding Transport Of Viral Material Towards Nucleus Microtubule-dependent Intracellular Transport Of Viral Material Towards Nucleus Hydroxypyruvate Reductase [NAD(P)H] Activity Hydroxypyruvate Reductase (NADH) Activity Glyoxylate Reductase (NADPH) Activity Hydroxypyruvate Reductase (NADPH) Activity Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Intracellular Transport Of Viral Protein In Host Cell Positive Regulation Of Osteoclast Proliferation Negative Regulation Of Apoptotic Process In Bone Marrow Cell Regulation Of Ryanodine-sensitive Calcium-release Channel Activity G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Hormone-mediated Apoptotic Signaling Pathway Adenylate Cyclase-activating G Protein-coupled CAMP Receptor Signaling Pathway Positive Regulation Of Cell Proliferation In Bone Marrow Negative Regulation Of Cell Differentiation Regulation Of Cell Proliferation In Bone Marrow Negative Regulation Of Bone Mineralization Involved In Bone Maturation Mitochondrion-endoplasmic Reticulum Membrane Tethering Positive Regulation Of Sequestering Of Calcium Ion Negative Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Transporter Inhibitor Activity Regulation Of Calcium Ion Export Across Plasma Membrane Negative Regulation Of Voltage-gated Calcium Channel Activity Autophagosome Membrane Docking Extracellular Region Spindle Intracellular Transport Of Virus Carboxylic Acid Binding Glyoxylate Metabolic Process Negative Regulation Of Developmental Process Host Cell Secretory Vesicle Negative Regulation Of Protein Sumoylation Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Peptide Hormone Receptor Binding Positive Regulation Of Inositol Phosphate Biosynthetic Process Magnesium Ion Homeostasis Titin Binding Calcium Channel Inhibitor Activity Regulation Of Voltage-gated Calcium Channel Activity Detection Of Calcium Ion Response To Metal Ion Response To Parathyroid Hormone
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