DYNLT1 and SYNJ2

		DYNLT1	SYNJ2
Description		dynein light chain Tctex-type 1	synaptojanin 2
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GO Annotations	Cellular Component	Extracellular Region Cytoplasm Golgi Apparatus Spindle Cytoskeleton Cytoplasmic Dynein Complex Microtubule Cytoplasmic Microtubule Dynein Complex Secretory Granule Lumen Host Cell Secretory Vesicle Ficolin-1-rich Granule Lumen	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane Cell Projection Membrane Raft Synapse Perinuclear Region Of Cytoplasm Presynapse
	Molecular Function	Protein Binding Identical Protein Binding Dynein Intermediate Chain Binding	Nucleic Acid Binding RNA Binding Phosphatidylinositol-3-phosphate Phosphatase Activity Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity Protein Binding Hydrolase Activity Phosphatase Activity Phosphatidylinositol Phosphate 4-phosphatase Activity Phosphatidylinositol-3,5-bisphosphate 5-phosphatase Activity Phosphatidylinositol-3,5-bisphosphate 3-phosphatase Activity Inositol-1,4,5-trisphosphate 5-phosphatase Activity Phosphatidylinositol Phosphate Phosphatase Activity
	Biological Process	Establishment Of Mitotic Spindle Orientation Microtubule-based Movement Nervous System Development Regulation Of G Protein-coupled Receptor Signaling Pathway Intracellular Transport Of Viral Protein In Host Cell Positive Regulation Of Intracellular Transport Symbiont Entry Into Host Cell Negative Regulation Of Neurogenesis Cell Division Microtubule-dependent Intracellular Transport Of Viral Material Towards Nucleus Transport Of Viral Material Towards Nucleus	Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phosphatidylinositol-3-phosphate Biosynthetic Process Phosphatidylinositol Dephosphorylation Synaptic Vesicle Endocytosis Membrane Organization
Pathways		Neutrophil degranulation	Synthesis of PIPs at the plasma membrane Clathrin-mediated endocytosis
Drugs
Diseases
GWAS			Age-related hearing impairment ( 34108613) Cannabis use (initiation) ( 22823124) Gamma glutamyl transferase levels ( 29403010 33339817) Intraocular pressure ( 29617998) Lipoprotein (a) levels ( 26377243) Platelet distribution width ( 32888494)
Interacting Genes		48 interacting genes: ACOX2 ACTN1 APP ARID4B BAG3 BMPR2 CCDC68 DDX54 DHX33 DNAJA2 DOC2A DOC2B DVL1 DVL2 DYNC1I1 DYNC1I2 FXR2 HAVCR1 HSPB7 HSPB9 ILF2 KIF2A KLK15 LNX1 NHSL2 NTAQ1 NUP153 NUP62 OLFM3 PELO PITX2 PSMA1 PTGES3L-AARSD1 PTH2R PVR RAD21 RBM14 RRAGA SDCBP SIRPA SVIL TCEANC TROAP TUBA3C TXN UXT VDAC1 XRN2	6 interacting genes: GRB2 ITSN1 ITSN2 NCK1 RAC1 SYNJ2BP
Entrez ID		6993	8871
HPRD ID		15987	10259
Ensembl ID		ENSG00000146425	ENSG00000078269
Uniprot IDs		P63172	A0A1W2PR85 B4DG94 O15056
PDB IDs		5JPW 8J07 8PR0 8PR1 8PTK 8RGI	1UFW
Enriched GO Terms of Interacting Partners?		Aggresome Chemical Synaptic Transmission Frizzled Binding Trans-synaptic Signaling Synaptic Signaling Synapse PTB Domain Binding Convergent Extension Involved In Neural Plate Elongation Microtubule-based Process Outflow Tract Morphogenesis Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cytoplasm Presynapse Regulation Of JNK Cascade Amyloid Fibril Formation Convergent Extension Involved In Organogenesis Regulation Of Spontaneous Synaptic Transmission Spindle Pole Convergent Extension Involved In Gastrulation Aggresome Assembly Spontaneous Neurotransmitter Secretion Synaptic Vesicle Exocytosis Positive Regulation Of Cellular Component Organization Transport Along Microtubule Vesicle-mediated Transport In Synapse Dynein Light Chain Binding Neurotransmitter Transport Positive Regulation Of Neuron Projection Arborization Neurotransmitter Secretion Protein-folding Chaperone Binding Cellular Response To Manganese Ion Regulated Exocytosis Regulation Of Exocytosis Centriolar Subdistal Appendage Inclusion Body Assembly Cytoskeleton-dependent Intracellular Transport Negative Regulation Of Transport Apoptotic Process Hsp70 Protein Binding Modulation Of Excitatory Postsynaptic Potential Positive Regulation Of Type 2 Mitophagy Cell-cell Signaling Microtubule-based Transport Programmed Cell Death Cell Death Microtubule Convergent Extension Calcium-dependent Activation Of Synaptic Vesicle Fusion Microtubule Motor Activity Response To Manganese Ion	Clathrin-dependent Synaptic Vesicle Endocytosis Protein-macromolecule Adaptor Activity Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Protein Polymerization Regulation Of Cellular Component Organization Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament Polymerization Regulation Of Actin Polymerization Or Depolymerization Endocytosis Regulation Of Actin Filament Length Presynaptic Membrane Intracellular Vesicle Positive Regulation Of Supramolecular Fiber Organization Regulation Of Cytoskeleton Organization Receptor-mediated Endocytosis Positive Regulation Of Cytoskeleton Organization Ephrin Receptor Binding Positive Regulation Of Protein-containing Complex Assembly Clathrin-dependent Endocytosis Import Into Cell Regulation Of MAPK Cascade Vesicle Membrane Lamellipodium Assembly Positive Regulation Of Dendritic Spine Development Synaptic Vesicle Endocytosis Regulation Of Cellular Component Size Regulation Of Actin Filament Organization Small GTPase-mediated Signal Transduction Lamellipodium Organization Presynaptic Endocytosis Regulation Of Dendritic Spine Development Regulation Of Endocytosis Regulation Of Actin Cytoskeleton Organization Guanyl-nucleotide Exchange Factor Adaptor Activity Transport Of Viral Material Towards Nucleus Microtubule-dependent Intracellular Transport Of Viral Material Towards Nucleus Regulation Of Actin Filament-based Process Regulation Of Signal Transduction Cytoskeleton Organization Regulation Of Intracellular Signal Transduction Regulation Of Protein-containing Complex Assembly Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Grb2-EGFR Complex Positive Regulation Of Ovarian Follicle Development Negative Regulation Of Interleukin-23 Production Regulation Of ERK5 Cascade Angiotensin-activated Signaling Pathway Involved In Heart Process Embryonic Olfactory Bulb Interneuron Precursor Migration Cerebral Cortex GABAergic Interneuron Development Vesicle-mediated Transport In Synapse
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