DYNLT1 and TUBA3C

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		DYNLT1	TUBA3C
Description		dynein light chain Tctex-type 1	tubulin alpha 3c
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Golgi Apparatus Spindle Cytoskeleton Cytoplasmic Dynein Complex Microtubule Cytoplasmic Microtubule Dynein Complex Secretory Granule Lumen Host Cell Secretory Vesicle Ficolin-1-rich Granule Lumen	Nucleus Cytoplasm Cytoskeleton Microtubule Cilium Microtubule Cytoskeleton
	Molecular Function	Protein Binding Identical Protein Binding Dynein Intermediate Chain Binding	Nucleotide Binding Structural Constituent Of Cytoskeleton GTP Binding Hydrolase Activity Metal Ion Binding
	Biological Process	Establishment Of Mitotic Spindle Orientation Microtubule-based Movement Nervous System Development Regulation Of G Protein-coupled Receptor Signaling Pathway Intracellular Transport Of Viral Protein In Host Cell Positive Regulation Of Intracellular Transport Symbiont Entry Into Host Cell Negative Regulation Of Neurogenesis Cell Division Microtubule-dependent Intracellular Transport Of Viral Material Towards Nucleus Transport Of Viral Material Towards Nucleus	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process
Pathways		Neutrophil degranulation	Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Recruitment of NuMA to mitotic centrosomes Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Cargo trafficking to the periciliary membrane Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins PKR-mediated signaling
Drugs
Diseases
GWAS			Coronary artery aneurysm in Kawasaki disease ( 27171184) Fasting blood insulin (BMI interaction) ( 22581228) Joint mobility (Beighton score) ( 27182965)
Interacting Genes		48 interacting genes: ACOX2 ACTN1 APP ARID4B BAG3 BMPR2 CCDC68 DDX54 DHX33 DNAJA2 DOC2A DOC2B DVL1 DVL2 DYNC1I1 DYNC1I2 FXR2 HAVCR1 HSPB7 HSPB9 ILF2 KIF2A KLK15 LNX1 NHSL2 NTAQ1 NUP153 NUP62 OLFM3 PELO PITX2 PSMA1 PTGES3L-AARSD1 PTH2R PVR RAD21 RBM14 RRAGA SDCBP SIRPA SVIL TCEANC TROAP TUBA3C TXN UXT VDAC1 XRN2	12 interacting genes: DYNLL1 DYNLT1 FYN GRM7 MYC NMI PFDN5 PXN SIAH1 TUBG1 UBC YWHAQ
Entrez ID		6993	7278
HPRD ID		15987	03958
Ensembl ID		ENSG00000146425	ENSG00000198033
Uniprot IDs		P63172	P0DPH7 Q1ZYQ1
PDB IDs		5JPW 8J07 8PR0 8PR1 8PTK 8RGI
Enriched GO Terms of Interacting Partners?		Aggresome Chemical Synaptic Transmission Frizzled Binding Trans-synaptic Signaling Synaptic Signaling Synapse PTB Domain Binding Convergent Extension Involved In Neural Plate Elongation Microtubule-based Process Outflow Tract Morphogenesis Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cytoplasm Presynapse Regulation Of JNK Cascade Amyloid Fibril Formation Convergent Extension Involved In Organogenesis Regulation Of Spontaneous Synaptic Transmission Spindle Pole Convergent Extension Involved In Gastrulation Aggresome Assembly Spontaneous Neurotransmitter Secretion Synaptic Vesicle Exocytosis Positive Regulation Of Cellular Component Organization Transport Along Microtubule Vesicle-mediated Transport In Synapse Dynein Light Chain Binding Neurotransmitter Transport Positive Regulation Of Neuron Projection Arborization Neurotransmitter Secretion Protein-folding Chaperone Binding Cellular Response To Manganese Ion Regulated Exocytosis Regulation Of Exocytosis Centriolar Subdistal Appendage Inclusion Body Assembly Cytoskeleton-dependent Intracellular Transport Negative Regulation Of Transport Apoptotic Process Hsp70 Protein Binding Modulation Of Excitatory Postsynaptic Potential Positive Regulation Of Type 2 Mitophagy Cell-cell Signaling Microtubule-based Transport Programmed Cell Death Cell Death Microtubule Convergent Extension Calcium-dependent Activation Of Synaptic Vesicle Fusion Microtubule Motor Activity Response To Manganese Ion	Spindle Identical Protein Binding G Protein-coupled Glutamate Receptor Signaling Pathway Cytoplasm Spindle Microtubule Glutamate Receptor Signaling Pathway Regulation Of Cellular Localization Detection Of Mechanical Stimulus Detection Of Mechanical Stimulus Involved In Sensory Perception Regulation Of Intrinsic Apoptotic Signaling Pathway Cellular Response To Glycine Regulation Of Cell Communication Response To Singlet Oxygen Regulation Of Signaling Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Acinar Cell Proliferation Positive Regulation Of Acinar Cell Proliferation SCF Ubiquitin Ligase Complex Binding RNA Polymerase III Assembly RNA Polymerase I Assembly Microtubule Associated Complex Cytoplasmic Dynein Complex Dynein Intermediate Chain Binding Transport Of Viral Material Towards Nucleus Positive Regulation Of Intracellular Transport Dynein Complex Microtubule-dependent Intracellular Transport Of Viral Material Towards Nucleus Substantia Nigra Development Cytosol Cytoplasmic Microtubule Protein Ubiquitination Modification-dependent Protein Catabolic Process Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Response To Glycine Scaffold Protein Binding Regulation Of Transport Group III Metabotropic Glutamate Receptor Activity Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Myc-Max Complex Regulation Of Acinar Cell Proliferation RNA Polymerase II Core Complex Assembly Regulation Of Intracellular Transport Intracellular Transport Of Viral Protein In Host Cell Microtubule Nucleator Activity Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing Neural Nucleus Development Response To Xenobiotic Stimulus T Cell Proliferation Protein Modification By Small Protein Conjugation Positive Regulation Of Establishment Of Protein Localization
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