DYNLT1 and TUBA3C

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		DYNLT1	TUBA3C
Gene Name		dynein, light chain, Tctex-type 1	tubulin, alpha 3c
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Apparatus Spindle Cytoplasmic Dynein Complex Microtubule	Nucleus Cytoplasm Microtubule
	Molecular Function	Motor Activity Protein Binding Identical Protein Binding	GTPase Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding
	Biological Process	Establishment Of Mitotic Spindle Orientation Mitotic Nuclear Division Metabolic Process Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Intracellular Transport Of Viral Protein In Host Cell Regulation Of Rac GTPase Activity Viral Entry Into Host Cell Neuron Projection Morphogenesis Negative Regulation Of Neurogenesis Cell Division Regulation Of Cytoskeleton Organization Microtubule-dependent Intracellular Transport Of Viral Material Towards Nucleus	Protein Folding Microtubule-based Process Cellular Protein Metabolic Process 'de Novo' Posttranslational Protein Folding Protein Polymerization
Pathways			Transport of connexons to the plasma membrane Mitotic Prometaphase Organelle biogenesis and maintenance Axon guidance Hedgehog 'off' state Separation of Sister Chromatids Translocation of GLUT4 to the plasma membrane G2/M Transition L1CAM interactions Mitotic Anaphase Recycling pathway of L1 Recruitment of NuMA to mitotic centrosomes Formation of tubulin folding intermediates by CCT/TriC Intraflagellar transport M Phase Prefoldin mediated transfer of substrate to CCT/TriC Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Post-chaperonin tubulin folding pathway Gap junction trafficking and regulation MHC class II antigen presentation Recruitment of mitotic centrosome proteins and complexes Protein folding Gap junction assembly Gap junction trafficking Kinesins Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Assembly of the primary cilium Factors involved in megakaryocyte development and platelet production Cell Cycle, Mitotic Resolution of Sister Chromatid Cohesion Chaperonin-mediated protein folding Signaling by Hedgehog Centrosome maturation Mitotic G2-G2/M phases Mitotic Metaphase and Anaphase Adaptive Immune System
Drugs			Epothilone D Epothilone B
Diseases
GWAS			Fasting insulin-related traits (interaction with BMI) ( 22581228)
Protein-Protein Interactions		16 interactors: APP BAG3 BMPR2 DOC2A DOC2B DVL1 DVL2 DYNC1I1 HSPB9 PVR RAD21 SVIL TROAP TUBA3C TXN VDAC1	11 interactors: DYNLL1 DYNLT1 FYN GRM7 MYC NMI PFDN5 PXN SIAH1 TUBG1 YWHAQ
Entrez ID		6993	7278
HPRD ID		15987	03958
Ensembl ID		ENSG00000146425
Uniprot IDs		P63172	Q13748 Q1ZYQ1
PDB IDs
Enriched GO Terms of Interacting Partners?		Convergent Extension Involved In Neural Plate Elongation Collateral Sprouting Convergent Extension Involved In Organogenesis Neural Plate Morphogenesis Planar Cell Polarity Pathway Involved In Neural Tube Closure Regulation Of Establishment Of Planar Polarity Involved In Neural Tube Closure Neurotransmitter Secretion Convergent Extension Neural Plate Development Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Neurotransmitter Levels Cochlea Morphogenesis Neurotransmitter Transport Cell-cell Signaling Non-canonical Wnt Signaling Pathway Secretion By Cell Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Cellular Localization Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Cochlea Development Neuromuscular Junction Development Regulation Of Binding Regulation Of Calcium Ion-dependent Exocytosis Secretion Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Protein Metabolic Process Morphogenesis Of An Epithelial Sheet Regulation Of Phosphorylation Regulation Of Protein Kinase Activity Microtubule-based Process Regulation Of Kinase Activity Regulation Of Lung Blood Pressure Synaptic Growth At Neuromuscular Junction Negative Regulation Of Chondrocyte Proliferation Susceptibility To T Cell Mediated Cytotoxicity Developmental Cell Growth Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Canonical Wnt Signaling Pathway Regulation Of Cellular Amino Acid Metabolic Process Nervous System Development Inner Ear Morphogenesis Negative Regulation Of Vasoconstriction Collateral Sprouting In Absence Of Injury Regulation Of Embryonic Development Apoptotic Process Signaling Positive Regulation Of Canonical Wnt Signaling Pathway Ear Morphogenesis	Regulation Of Signaling Regulation Of Signal Transduction Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Metabolic Process Regulation Of Cellular Component Organization Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Substantia Nigra Development Positive Regulation Of Signal Transduction Cell Cycle Multicellular Organismal Development Regulation Of Apoptotic Process Neural Nucleus Development Anatomical Structure Development Anatomical Structure Morphogenesis Positive Regulation Of Mitochondrion Organization Regulation Of Cell Death Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Microtubule-dependent Intracellular Transport Of Viral Material Towards Nucleus Regulation Of Organelle Organization Developmental Process Regulation Of Intracellular Signal Transduction Midbrain Development Apoptotic Process Programmed Cell Death System Development Regulation Of Mitochondrion Organization Regulation Of Cellular Localization Intracellular Signal Transduction Feeding Behavior Cell Cycle Process Fibroblast Apoptotic Process Cell Death Cell Morphogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Death Cytoskeleton Organization Cell Projection Organization G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cellular Metabolic Process Viral Process Learning Cellular Response To Growth Factor Stimulus Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cell Shape Response To Growth Factor
Tagcloud ?		1inq53a 250viqd 52gqvd adapter attempt capsid defective dynein hiv immunodeficiency integrase interaction kd ma motifs mutational p150glued particulate predicts proper q252a replication requirement reverse steps tctex transcriptase uncoating
Tagcloud (Difference) ?		1inq53a 250viqd 52gqvd adapter attempt capsid defective dynein hiv immunodeficiency integrase interaction kd ma motifs mutational p150glued particulate predicts proper q252a replication requirement reverse steps tctex transcriptase uncoating
Tagcloud (Intersection) ?