TXN and NFE2

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		TXN	NFE2
Gene Name		thioredoxin	nuclear factor, erythroid 2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Extracellular Vesicular Exosome	Nucleus Nucleoplasm Cytoplasm Actin Cytoskeleton PML Body
	Molecular Function	Protein Binding Protein Disulfide Oxidoreductase Activity Peptide Disulfide Oxidoreductase Activity Poly(A) RNA Binding	Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Sequence-specific DNA Binding Protein N-terminus Binding WW Domain Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Reactive Oxygen Species Transcription, DNA-templated Glycerol Ether Metabolic Process Movement Of Cell Or Subcellular Component Signal Transduction Cell-cell Signaling Cell Proliferation Response To Radiation Nucleobase-containing Small Molecule Interconversion Activation Of Protein Kinase B Activity Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Protein Import Into Nucleus, Translocation Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of DNA Binding Small Molecule Metabolic Process Innate Immune Response Cell Redox Homeostasis Negative Regulation Of Protein Export From Nucleus Positive Regulation Of Protein Kinase B Signaling Nucleobase-containing Small Molecule Metabolic Process Oxidation-reduction Process Negative Regulation Of Hydrogen Peroxide-induced Cell Death	Nucleosome Disassembly Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Cell-cell Signaling Multicellular Organismal Development Blood Coagulation Hemostasis Blood Circulation Negative Regulation Of Bone Mineralization Negative Regulation Of Syncytium Formation By Plasma Membrane Fusion Positive Regulation Of Transcription, DNA-templated Labyrinthine Layer Blood Vessel Development Positive Regulation Of Peptidyl-lysine Acetylation
Pathways		The NLRP3 inflammasome Inflammasomes Oxidative Stress Induced Senescence Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways Cellular Senescence Detoxification of Reactive Oxygen Species Metabolism of nucleotides Synthesis and interconversion of nucleotide di- and triphosphates Innate Immune System	Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS			Mean platelet volume ( 22139419)
Protein-Protein Interactions		22 interactors: ACTN4 APEX1 CDKN1A COL1A1 COPS5 DNAJA1 DYNLT1 FST GFER GPRASP2 MAP3K5 MLH1 MYD88 NCF4 NFE2 NFKB1 NR3C1 SIAH1 TP53 TXNIP UCHL5 VIM	21 interactors: ATF4 BTRC CREBBP ELF5 HMGN1 ITCH KAT2B MAFF MAFG MAFK MAPK8 NEDD4 NFE2L2 NFE2L3 PEX14 PHYHIP SCAND1 SSX5 TXN WWP1 YAP1
Entrez ID		7295	4778
HPRD ID		01761	09030
Ensembl ID		ENSG00000136810	ENSG00000123405
Uniprot IDs		H9ZYJ2 P10599	A8K3E0 Q16621
PDB IDs		1AIU 1AUC 1CQG 1CQH 1ERT 1ERU 1ERV 1ERW 1M7T 1MDI 1MDJ 1MDK 1TRS 1TRU 1TRV 1TRW 1W1C 1W1E 2HSH 2HXK 2IFQ 2IIY 3E3E 3KD0 3M9J 3M9K 3QFA 3QFB 3TRX 4TRX	1LVX 2KZ5
Enriched GO Terms of Interacting Partners?		Regulation Of Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Apoptotic Process Regulation Of Cell Death Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Signal Transduction Cell Communication Response To Stress Response To Oxidative Stress Response To Stimulus Regulation Of Signaling Response To Abiotic Stimulus Response To Hydrogen Peroxide Signaling Immune System Process Cellular Response To Stimulus Positive Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Immune Response Cellular Response To Growth Factor Stimulus Positive Regulation Of Apoptotic Process Response To Growth Factor Regulation Of Cellular Process Apoptotic Process Regulation Of JNK Cascade Signal Transduction Programmed Cell Death Intrinsic Apoptotic Signaling Pathway Response To Organic Substance Cell Death Regulation Of Stress-activated MAPK Cascade Death Response To Reactive Oxygen Species Positive Regulation Of Cellular Metabolic Process Cellular Response To Stress Developmental Process Epithelium Development Intracellular Receptor Signaling Pathway Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Neuron Death Response To Mechanical Stimulus Cellular Response To Mechanical Stimulus Stress-induced Premature Senescence Anatomical Structure Development Negative Regulation Of Catalytic Activity Response To Inorganic Substance System Development Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway	Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Process Cellular Metabolic Process Negative Regulation Of Oxidative Stress-induced Cell Death Positive Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process N-terminal Peptidyl-lysine Acetylation Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Response To Stress Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Viral Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Regulation Of Cellular Response To Oxidative Stress Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Biosynthetic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Biosynthetic Process Response To Radiation N-terminal Protein Amino Acid Acetylation Negative Regulation Of Hydrogen Peroxide-induced Cell Death Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Modification-dependent Protein Catabolic Process Regulation Of Hydrogen Peroxide-induced Cell Death Negative Regulation Of Gene Expression
Tagcloud ?		alphascreen ammp calnexin cndp2 combines hsp90aa1 hsp90b1 hspa1b hspa5 hspa9 identifier imbalance itraq nfhcc nonfibrotic nontumor p4hb pdia6 phosphoproteomics pointed proteomexchange proteomics proteostasis pxd001253 resident ser583 ubc unraveling vcp	bear bzip cdna cnc construct designated exert functionally globin heterodimers hmaf homodimerize homodimers k562 kilobase lacks leucine library maf nrf1 nrf2 opposite p45 pair probe recognizable repeat tandem zipper
Tagcloud (Difference) ?		alphascreen ammp calnexin cndp2 combines hsp90aa1 hsp90b1 hspa1b hspa5 hspa9 identifier imbalance itraq nfhcc nonfibrotic nontumor p4hb pdia6 phosphoproteomics pointed proteomexchange proteomics proteostasis pxd001253 resident ser583 ubc unraveling vcp	bear bzip cdna cnc construct designated exert functionally globin heterodimers hmaf homodimerize homodimers k562 kilobase lacks leucine library maf nrf1 nrf2 opposite p45 pair probe recognizable repeat tandem zipper
Tagcloud (Intersection) ?