DYNLT1 and DVL2

Number of citations of the paper that reports this interaction (PMID 10644691)
17

Data Source:
HPRD (two hybrid)

		DYNLT1	DVL2
Gene Name		dynein, light chain, Tctex-type 1	dishevelled segment polarity protein 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Apparatus Spindle Cytoplasmic Dynein Complex Microtubule	Nucleus Cytoplasm Cytosol Plasma Membrane Cytoplasmic Vesicle Apical Part Of Cell Clathrin-coated Endocytic Vesicle
	Molecular Function	Motor Activity Protein Binding Identical Protein Binding	Frizzled Binding Protein Binding Protein Domain Specific Binding Identical Protein Binding Protein Self-association
	Biological Process	Establishment Of Mitotic Spindle Orientation Mitotic Nuclear Division Metabolic Process Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Intracellular Transport Of Viral Protein In Host Cell Regulation Of Rac GTPase Activity Viral Entry Into Host Cell Neuron Projection Morphogenesis Negative Regulation Of Neurogenesis Cell Division Regulation Of Cytoskeleton Organization Microtubule-dependent Intracellular Transport Of Viral Material Towards Nucleus	Neural Tube Closure Positive Regulation Of Protein Phosphorylation Outflow Tract Morphogenesis Transcription From RNA Polymerase II Promoter Segment Specification Heart Development Wnt Signaling Pathway Convergent Extension Involved In Neural Plate Elongation Cellular Protein Localization Hippo Signaling Non-canonical Wnt Signaling Pathway Positive Regulation Of JUN Kinase Activity Canonical Wnt Signaling Pathway Involved In Regulation Of Cell Proliferation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Canonical Wnt Signaling Pathway Cochlea Morphogenesis Planar Cell Polarity Pathway Involved In Neural Tube Closure Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways			misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Signaling by Wnt negative regulation of TCF-dependent signaling by DVL-interacting proteins beta-catenin independent WNT signaling disassembly of the destruction complex and recruitment of AXIN to the membrane WNT mediated activation of DVL Signaling by Hippo TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation Asymmetric localization of PCP proteins WNT5A-dependent internalization of FZD4 XAV939 inhibits tankyrase, stabilizing AXIN degradation of DVL Signaling by WNT in cancer PCP/CE pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions		16 interactors: APP BAG3 BMPR2 DOC2A DOC2B DVL1 DVL2 DYNC1I1 HSPB9 PVR RAD21 SVIL TROAP TUBA3C TXN VDAC1	61 interactors: AP1M1 AP2M1 ARHGEF39 ARR3 ARRB1 ARRB2 ATN1 AXIN1 BAG3 BAHD1 CCDC33 CPSF7 CSNK1E CTBP2 DAAM1 DDI1 DPPA2 DYNLT1 ENKD1 FZD4 GABARAP GABARAPL1 ITCH LRRK2 MAP1LC3A MCRS1 OTULIN PARD6A PCBD1 PLA2G12A POLI PPM1A PRKCA PRKCB PRKCG PRPF3 RAC1 RBFOX1 RBPMS RHOA RHOXF2 RNF185 RNPS1 RUNX2 SMURF1 SNF8 SNIP1 SORBS3 TCEB3B THAP1 TIFA TP53 TRAF2 U2AF2 USP5 VANGL1 VHL ZBTB8A ZNF165 ZNF250 ZNF263
Entrez ID		6993	1856
HPRD ID		15987	03690
Ensembl ID		ENSG00000146425	ENSG00000004975
Uniprot IDs		P63172	I3L2N2 O14641
PDB IDs			2REY 3CBX 3CBY 3CBZ 3CC0
Enriched GO Terms of Interacting Partners?		Convergent Extension Involved In Neural Plate Elongation Collateral Sprouting Convergent Extension Involved In Organogenesis Neural Plate Morphogenesis Planar Cell Polarity Pathway Involved In Neural Tube Closure Regulation Of Establishment Of Planar Polarity Involved In Neural Tube Closure Neurotransmitter Secretion Convergent Extension Neural Plate Development Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Neurotransmitter Levels Cochlea Morphogenesis Neurotransmitter Transport Cell-cell Signaling Non-canonical Wnt Signaling Pathway Secretion By Cell Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Cellular Localization Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Cochlea Development Neuromuscular Junction Development Regulation Of Binding Regulation Of Calcium Ion-dependent Exocytosis Secretion Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Protein Metabolic Process Morphogenesis Of An Epithelial Sheet Regulation Of Phosphorylation Regulation Of Protein Kinase Activity Microtubule-based Process Regulation Of Kinase Activity Regulation Of Lung Blood Pressure Synaptic Growth At Neuromuscular Junction Negative Regulation Of Chondrocyte Proliferation Susceptibility To T Cell Mediated Cytotoxicity Developmental Cell Growth Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Canonical Wnt Signaling Pathway Regulation Of Cellular Amino Acid Metabolic Process Nervous System Development Inner Ear Morphogenesis Negative Regulation Of Vasoconstriction Collateral Sprouting In Absence Of Injury Regulation Of Embryonic Development Apoptotic Process Signaling Positive Regulation Of Canonical Wnt Signaling Pathway Ear Morphogenesis	Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Gene Expression RNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Cellular Response To Growth Factor Stimulus Nucleobase-containing Compound Metabolic Process Response To Growth Factor Regulation Of Signal Transduction Cellular Nitrogen Compound Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Platelet Activation Cellular Metabolic Process Regulation Of Cellular Process Cell Death Death Cellular Macromolecule Biosynthetic Process Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Organic Substance Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Signaling Negative Regulation Of Signal Transduction Macromolecule Biosynthetic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Nitrogen Compound Metabolic Process Regulation Of Intracellular Signal Transduction Apoptotic Process Catabolic Process Negative Regulation Of Signaling Programmed Cell Death Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Phosphorylation Cellular Response To Transforming Growth Factor Beta Stimulus Membrane Organization Positive Regulation Of Protein Metabolic Process Viral Process Histone H3-T6 Phosphorylation Response To Transforming Growth Factor Beta
Tagcloud ?		1inq53a 250viqd 52gqvd adapter attempt capsid defective dynein hiv immunodeficiency integrase interaction kd ma motifs mutational p150glued particulate predicts proper q252a replication requirement reverse steps tctex transcriptase uncoating	adaptor ap2 ap2mu2 assembled assembles blockage clathrin clustering continuously disassembled dissolution endocytic endocytosis follows fz inhibiton internalization lrp6 maintain mu2 path rab routes signalosome take transducer transducers vertebrates wnt
Tagcloud (Difference) ?		1inq53a 250viqd 52gqvd adapter attempt capsid defective dynein hiv immunodeficiency integrase interaction kd ma motifs mutational p150glued particulate predicts proper q252a replication requirement reverse steps tctex transcriptase uncoating	adaptor ap2 ap2mu2 assembled assembles blockage clathrin clustering continuously disassembled dissolution endocytic endocytosis follows fz inhibiton internalization lrp6 maintain mu2 path rab routes signalosome take transducer transducers vertebrates wnt
Tagcloud (Intersection) ?