DYNLT1 and DOC2B

Number of citations: 0 (PubMedID 9804756)
Data Source: HPRD (in vitro, in vivo)

		DYNLT1	DOC2B
Name		dynein light chain Tctex-type 1	double C2 domain beta
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Golgi Apparatus Spindle Cytoskeleton Cytoplasmic Dynein Complex Microtubule Cytoplasmic Microtubule Dynein Complex Secretory Granule Lumen Host Cell Secretory Vesicle Ficolin-1-rich Granule Lumen	Cytoplasm Plasma Membrane Membrane SNARE Complex Synapse Presynapse
	Molecular Function	Protein Binding Identical Protein Binding Dynein Intermediate Chain Binding	Calcium Ion Binding Calcium-dependent Phospholipid Binding Syntaxin Binding Metal Ion Binding
	Biological Process	Establishment Of Mitotic Spindle Orientation Microtubule-based Movement Nervous System Development Regulation Of G Protein-coupled Receptor Signaling Pathway Intracellular Transport Of Viral Protein In Host Cell Positive Regulation Of Intracellular Transport Symbiont Entry Into Host Cell Negative Regulation Of Neurogenesis Cell Division Microtubule-dependent Intracellular Transport Of Viral Material Towards Nucleus Transport Of Viral Material Towards Nucleus	Chemical Synaptic Transmission Intracellular Protein Localization Positive Regulation Of Vesicle Fusion Positive Regulation Of Insulin Secretion Positive Regulation Of Calcium Ion-dependent Exocytosis Calcium Ion-regulated Exocytosis Of Neurotransmitter Spontaneous Neurotransmitter Secretion Calcium-dependent Activation Of Synaptic Vesicle Fusion
Pathways		Neutrophil degranulation	None
GWAS		No GWAS studies recorded	No GWAS studies recorded
Novel Interactors		7 novel interactors: ACAT2 CRHBP ERO1A PRKN RPS6KA2 SYNJ2 TMEM143	None recorded
Interacting Genes		48 interacting genes: ACOX2 ACTN1 APP ARID4B BAG3 BMPR2 CCDC68 DDX54 DHX33 DNAJA2 DOC2A DOC2B DVL1 DVL2 DYNC1I1 DYNC1I2 FXR2 HAVCR1 HSPB7 HSPB9 ILF2 KIF2A KLK15 LNX1 NHSL2 NTAQ1 NUP153 NUP62 OLFM3 PELO PITX2 PSMA1 PTGES3L-AARSD1 PTH2R PVR RAD21 RBM14 RRAGA SDCBP SIRPA SVIL TCEANC TROAP TUBA3C TXN UXT VDAC1 XRN2	3 interacting genes: DYNLT1 STXBP1 UNC13B
Entrez ID		6993	8447
HPRD ID		15987	05196
Ensembl ID		ENSG00000146425	ENSG00000272636
Uniprot IDs		P63172	Q14184
PDB IDs		5JPW 8J07 8PR0 8PR1 8PTK 8RGI	Not available
GO Terms Enriched among Interactors		Aggresome Chemical Synaptic Transmission Frizzled Binding Trans-synaptic Signaling Synaptic Signaling Synapse PTB Domain Binding Convergent Extension Involved In Neural Plate Elongation Microtubule-based Process Outflow Tract Morphogenesis Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cytoplasm Presynapse Regulation Of JNK Cascade Amyloid Fibril Formation Convergent Extension Involved In Organogenesis Regulation Of Spontaneous Synaptic Transmission Spindle Pole Convergent Extension Involved In Gastrulation Aggresome Assembly Spontaneous Neurotransmitter Secretion Synaptic Vesicle Exocytosis Positive Regulation Of Cellular Component Organization Transport Along Microtubule Vesicle-mediated Transport In Synapse Dynein Light Chain Binding Neurotransmitter Transport Positive Regulation Of Neuron Projection Arborization Neurotransmitter Secretion Protein-folding Chaperone Binding Cellular Response To Manganese Ion Regulated Exocytosis Regulation Of Exocytosis Centriolar Subdistal Appendage Inclusion Body Assembly Cytoskeleton-dependent Intracellular Transport Negative Regulation Of Transport Apoptotic Process Hsp70 Protein Binding Modulation Of Excitatory Postsynaptic Potential Positive Regulation Of Type 2 Mitophagy Cell-cell Signaling Microtubule-based Transport Programmed Cell Death Cell Death Microtubule Convergent Extension Calcium-dependent Activation Of Synaptic Vesicle Fusion Microtubule Motor Activity Response To Manganese Ion	Dense Core Granule Exocytosis Neuronal Dense Core Vesicle Exocytosis Regulation Of Synaptic Vesicle Priming Secretory Granule Localization Establishment Of Organelle Localization Syntaxin-1 Binding Synaptic Vesicle Priming Calcium-ion Regulated Exocytosis Vesicle Docking Involved In Exocytosis Organelle Localization Vesicle Docking Organelle Localization By Membrane Tethering Membrane Docking Positive Regulation Of Transport Regulated Exocytosis Establishment Of Vesicle Localization Vesicle Localization Positive Regulation Of Vesicle Docking Transport Of Viral Material Towards Nucleus Microtubule-dependent Intracellular Transport Of Viral Material Towards Nucleus Positive Regulation Of Synaptic Vesicle Priming Intracellular Transport Of Viral Protein In Host Cell Dense Core Granule Priming Exocytosis Axon Target Recognition Regulation Of Acrosomal Vesicle Exocytosis Extrinsic Component Of Presynaptic Membrane Presynaptic Dense Core Vesicle Exocytosis Positive Regulation Of Glutamate Secretion, Neurotransmission Negative Regulation Of Synaptic Transmission, GABAergic Establishment Of Localization In Cell Regulation Of Transport Platelet Degranulation Regulation Of Glutamate Secretion, Neurotransmission Positive Regulation Of Secretion By Cell Acrosomal Vesicle Exocytosis Chemical Synaptic Transmission Positive Regulation Of Secretion Positive Regulation Of Inhibitory Postsynaptic Potential Trans-synaptic Signaling Synaptic Signaling Modulation Of Inhibitory Postsynaptic Potential Synaptic Vesicle Maturation Intracellular Transport Of Virus Secretion By Cell Calcium Ion-regulated Exocytosis Of Neurotransmitter Host Cell Secretory Vesicle Regulation Of Protein-containing Complex Assembly Positive Regulation Of Glutamate Secretion