TXN and TXNIP

Number of citations of the paper that reports this interaction (PubMedID 10419473)
0

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		TXN	TXNIP
Description		thioredoxin	thioredoxin interacting protein
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol Extracellular Exosome	Nucleus Cytoplasm Cytosol
	Molecular Function	RNA Binding Thioredoxin-disulfide Reductase (NADPH) Activity Protein Binding Protein-disulfide Reductase Activity Protein Homodimerization Activity Protein-disulfide Reductase [NAD(P)H] Activity	Enzyme Inhibitor Activity Protein Binding Ubiquitin Protein Ligase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Response To Radiation Cellular Homeostasis Positive Regulation Of DNA Binding Cell Redox Homeostasis Negative Regulation Of Protein Export From Nucleus Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Detoxification Of Hydrogen Peroxide Response To Nitric Oxide	Negative Regulation Of Transcription By RNA Polymerase II Protein Import Into Nucleus Inflammatory Response Response To Oxidative Stress Response To Xenobiotic Stimulus Response To Mechanical Stimulus Response To Glucose Protein Transport Keratinocyte Differentiation Response To Estradiol Response To Progesterone Regulation Of Cell Population Proliferation Response To Hydrogen Peroxide Positive Regulation Of Apoptotic Process Platelet-derived Growth Factor Receptor Signaling Pathway Response To Calcium Ion Negative Regulation Of Cell Division Cellular Response To Tumor Cell Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus
Pathways		Oxidative Stress Induced Senescence Detoxification of Reactive Oxygen Species Interconversion of nucleotide di- and triphosphates TP53 Regulates Metabolic Genes Protein repair The NLRP3 inflammasome The NLRP3 inflammasome Regulation of FOXO transcriptional activity by acetylation Purinergic signaling in leishmaniasis infection Purinergic signaling in leishmaniasis infection NFE2L2 regulating anti-oxidant/detoxification enzymes	The NLRP3 inflammasome The NLRP3 inflammasome Regulation of FOXO transcriptional activity by acetylation Purinergic signaling in leishmaniasis infection Purinergic signaling in leishmaniasis infection Cytoprotection by HMOX1
Drugs		Phenethyl Isothiocyanate
Diseases
GWAS		Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mean corpuscular hemoglobin ( 32888494) Mean reticulocyte volume ( 32888494)
Interacting Genes		43 interacting genes: ACTN1 ACTN4 ANKRD11 APEX1 C1QA C4BPA CDKN1A CEBPA CFP COL1A1 COPS5 DDIT4L DNAJA1 DYNLT1 EGFR ERBB2 ERBB3 ERBB4 FNDC3B FST GFER GPRASP2 MAP3K5 MLH1 MRFAP1 MYD88 NCF4 NFE2 NFKB1 NIF3L1 NR3C1 NUP62 PTEN SERTAD3 SIAH1 SPG21 SRPK2 TEX13A TP53 TRAF2 TXNIP UCHL5 VIM	30 interacting genes: CBX8 DDIT4 ECD EEF1A1 FHL1 GAPDH HDAC1 HDAC3 HSPB2 IDI1 INTS9 KPNA2 LUC7L3 MAPK1 NLGN3 PRKAA1 PTPN11 RUVBL2 SCEL SIVA1 SLC2A1 SMURF2 TRAF6 TXN TXNRD1 UBR5 UXT WWP1 ZBTB16 ZBTB32
Entrez ID		7295	10628
HPRD ID		01761	05964
Ensembl ID		ENSG00000136810	ENSG00000265972
Uniprot IDs		H9ZYJ2 P10599	Q9H3M7
PDB IDs		1AIU 1AUC 1CQG 1CQH 1ERT 1ERU 1ERV 1ERW 1M7T 1MDI 1MDJ 1MDK 1TRS 1TRU 1TRV 1TRW 2HSH 2HXK 2IFQ 2IIY 3E3E 3KD0 3M9J 3M9K 3QFA 3QFB 3TRX 4LL1 4LL4 4OO4 4OO5 4POK 4POL 4POM 4PUF 4TRX 5DQY	4GEI 4GEJ 4GFX 4LL1 4LL4 4ROF 4ROJ 5CQ2 5DF6 5DWS 5DZD
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Programmed Cell Death Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Apoptotic Process Regulation Of Nucleobase-containing Compound Metabolic Process Identical Protein Binding Regulation Of RNA Metabolic Process Intracellular Signaling Cassette Regulation Of Primary Metabolic Process Response To Epidermal Growth Factor Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Developmental Process Regulation Of Gene Expression ERBB2 Signaling Pathway Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Epidermal Growth Factor Receptor Signaling Pathway Response To Stress ERBB Signaling Pathway Cytoplasm Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Intracellular Signal Transduction Regulation Of Metabolic Process Positive Regulation Of Signal Transduction Cell Differentiation Cellular Response To Epidermal Growth Factor Stimulus ERBB3:ERBB2 Complex Positive Regulation Of Programmed Cell Death Glial Cell Differentiation Ubiquitin Protein Ligase Binding Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Response To Growth Factor Positive Regulation Of Cell Communication Positive Regulation Of Intracellular Signal Transduction Signal Transduction Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Signaling Epidermal Growth Factor Receptor Activity Neuregulin Receptor Activity Cellular Senescence Programmed Necrotic Cell Death Positive Regulation Of MiRNA Metabolic Process	Nucleus Cytosol Cytoplasm Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Protein Lysine Delactylase Activity Regulation Of Signal Transduction Positive Regulation Of Type I Interferon Production Negative Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Nucleoplasm Protein Decrotonylase Activity Histone Decrotonylase Activity Regulation Of RNA Biosynthetic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Protein Export From Nucleus Regulation Of Protein Stability Regulation Of Gene Expression Positive Regulation Of Signal Transduction Protein Modification Process Regulation Of Cell Communication Regulation Of Macromolecule Biosynthetic Process Regulation Of Signaling Regulation Of RNA Metabolic Process Regulation Of Nucleocytoplasmic Transport Thioredoxin-disulfide Reductase (NADPH) Activity Regulation Of Canonical Wnt Signaling Pathway Regulation Of Primary Metabolic Process Regulation Of Type I Interferon Production Histone Deacetylase Binding Negative Regulation Of Protein Export From Nucleus Transcription Corepressor Binding Regulation Of Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Macromolecule Metabolic Process Regulation Of Intracellular Transport Response To Epidermal Growth Factor Regulation Of Intracellular Protein Transport Histone Deacetylase Activity, Hydrolytic Mechanism Bergmann Glial Cell Differentiation
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