DYNLT1 and DDX54

Number of citations of the paper that reports this interaction (PubMedID 30217970)
38

Data Source:
BioGRID (two hybrid)

		DYNLT1	DDX54
Description		dynein light chain Tctex-type 1	DEAD-box helicase 54
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GO Annotations	Cellular Component	Extracellular Region Cytoplasm Golgi Apparatus Spindle Cytoskeleton Cytoplasmic Dynein Complex Microtubule Cytoplasmic Microtubule Dynein Complex Secretory Granule Lumen Host Cell Secretory Vesicle Ficolin-1-rich Granule Lumen	Nucleus Nucleoplasm Nucleolus Golgi Apparatus Membrane
	Molecular Function	Protein Binding Identical Protein Binding Dynein Intermediate Chain Binding	Nucleotide Binding Nucleic Acid Binding Transcription Corepressor Activity RNA Binding RNA Helicase Activity Helicase Activity Signaling Receptor Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Nuclear Estrogen Receptor Binding
	Biological Process	Establishment Of Mitotic Spindle Orientation Microtubule-based Movement Nervous System Development Regulation Of G Protein-coupled Receptor Signaling Pathway Intracellular Transport Of Viral Protein In Host Cell Positive Regulation Of Intracellular Transport Symbiont Entry Into Host Cell Negative Regulation Of Neurogenesis Cell Division Microtubule-dependent Intracellular Transport Of Viral Material Towards Nucleus Transport Of Viral Material Towards Nucleus	RRNA Processing RNA Processing RNA Metabolic Process Estrogen Receptor Signaling Pathway Negative Regulation Of DNA-templated Transcription
Pathways		Neutrophil degranulation
Drugs
Diseases
GWAS			Body mass index ( 26426971) Response to fenofibrate (adiponectin levels) ( 23149075)
Interacting Genes		48 interacting genes: ACOX2 ACTN1 APP ARID4B BAG3 BMPR2 CCDC68 DDX54 DHX33 DNAJA2 DOC2A DOC2B DVL1 DVL2 DYNC1I1 DYNC1I2 FXR2 HAVCR1 HSPB7 HSPB9 ILF2 KIF2A KLK15 LNX1 NHSL2 NTAQ1 NUP153 NUP62 OLFM3 PELO PITX2 PSMA1 PTGES3L-AARSD1 PTH2R PVR RAD21 RBM14 RRAGA SDCBP SIRPA SVIL TCEANC TROAP TUBA3C TXN UXT VDAC1 XRN2	21 interacting genes: APP CASK CSNK2A1 DVL3 DYNLT1 ESR1 ESR2 NEDD4 NEDD4L NR3C1 PGR PJA1 POLR2G PTPRD RNF10 SEMA4A SMURF1 TMED9 USP7 YWHAE ZNF394
Entrez ID		6993	79039
HPRD ID		15987	13129
Ensembl ID		ENSG00000146425	ENSG00000123064
Uniprot IDs		P63172	Q8TDD1
PDB IDs		5JPW 8J07 8PR0 8PR1 8PTK 8RGI	8FKT 8FKU 8FKV 8FKW 8FKX 8FKY
Enriched GO Terms of Interacting Partners?		Aggresome Chemical Synaptic Transmission Frizzled Binding Trans-synaptic Signaling Synaptic Signaling Synapse PTB Domain Binding Convergent Extension Involved In Neural Plate Elongation Microtubule-based Process Outflow Tract Morphogenesis Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cytoplasm Presynapse Regulation Of JNK Cascade Amyloid Fibril Formation Convergent Extension Involved In Organogenesis Regulation Of Spontaneous Synaptic Transmission Spindle Pole Convergent Extension Involved In Gastrulation Aggresome Assembly Spontaneous Neurotransmitter Secretion Synaptic Vesicle Exocytosis Positive Regulation Of Cellular Component Organization Transport Along Microtubule Vesicle-mediated Transport In Synapse Dynein Light Chain Binding Neurotransmitter Transport Positive Regulation Of Neuron Projection Arborization Neurotransmitter Secretion Protein-folding Chaperone Binding Cellular Response To Manganese Ion Regulated Exocytosis Regulation Of Exocytosis Centriolar Subdistal Appendage Inclusion Body Assembly Cytoskeleton-dependent Intracellular Transport Negative Regulation Of Transport Apoptotic Process Hsp70 Protein Binding Modulation Of Excitatory Postsynaptic Potential Positive Regulation Of Type 2 Mitophagy Cell-cell Signaling Microtubule-based Transport Programmed Cell Death Cell Death Microtubule Convergent Extension Calcium-dependent Activation Of Synaptic Vesicle Fusion Microtubule Motor Activity Response To Manganese Ion	Estrogen Response Element Binding Steroid Binding Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Nuclear Receptor-mediated Signaling Pathway Intracellular Receptor Signaling Pathway Nuclear Receptor Activity Hormone-mediated Signaling Pathway Receptor Catabolic Process Nuclear Steroid Receptor Activity Positive Regulation Of Catabolic Process Symbiont-mediated Disruption Of Host Cell PML Body Positive Regulation Of Metabolic Process Protein Ubiquitination Enzyme Binding Nuclear Estrogen Receptor Activity Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Regulation Of Cell Morphogenesis Positive Regulation Of Macromolecule Metabolic Process Protein Modification By Small Protein Conjugation Regulation Of Toll-like Receptor Signaling Pathway Nuclear Receptor-mediated Corticosteroid Signaling Pathway Intracellular Signal Transduction Macromolecule Catabolic Process Phosphoserine Residue Binding Negative Regulation Of Potassium Ion Export Across Plasma Membrane Regulation Of Synapse Organization Receptor Metabolic Process Regulation Of RNA Metabolic Process Protein Targeting To Vacuole Sodium Channel Inhibitor Activity Post-translational Protein Modification Protein Monoubiquitination Regulation Of Transcription By RNA Polymerase II Regulation Of Cellular Component Organization Regulation Of Anatomical Structure Morphogenesis Regulation Of Metal Ion Transport Regulation Of Primary Metabolic Process Ubiquitin Protein Ligase Activity Establishment Of Protein Localization To Vacuole Regulation Of Dendrite Morphogenesis Signal Transduction Potassium Channel Inhibitor Activity Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Protein Catabolic Process Protein Catabolic Process Regulation Of Potassium Ion Transmembrane Transport Regulation Of DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Biosynthetic Process
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