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TXK and CCR5
Number of citations of the paper that reports this interaction (PubMedID
11859127
)
0
Data Source:
HPRD
(in vivo)
TXK
CCR5
Description
TXK tyrosine kinase
C-C motif chemokine receptor 5
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Plasma Membrane
Membrane
Cytoplasm
Endosome
Plasma Membrane
External Side Of Plasma Membrane
Cell Surface
Membrane
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Virus Receptor Activity
Actin Binding
Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity
G Protein-coupled Receptor Activity
Chemokine Receptor Activity
Protein Binding
Coreceptor Activity
C-C Chemokine Receptor Activity
C-C Chemokine Binding
Identical Protein Binding
Chemokine (C-C Motif) Ligand 5 Binding
Biological Process
Positive Regulation Of Cytokine Production
Adaptive Immune Response
Immune System Process
Protein Phosphorylation
Regulation Of Gene Expression
Positive Regulation Of Type II Interferon Production
Positive Regulation Of Transcription By RNA Polymerase II
Protein Autophosphorylation
T Cell Receptor Signaling Pathway
Positive Regulation Of Type II Interferon-mediated Signaling Pathway
MAPK Cascade
Dendritic Cell Chemotaxis
Calcium Ion Transport
Apoptotic Process
Chemotaxis
Defense Response
Inflammatory Response
Immune Response
Cellular Defense Response
Signal Transduction
Cell Surface Receptor Signaling Pathway
G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
Cell-cell Signaling
Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum
Calcium-mediated Signaling
Signaling
Symbiont Entry Into Host Cell
Cell Chemotaxis
Chemokine-mediated Signaling Pathway
Response To Cholesterol
Cellular Response To Lipopolysaccharide
Cellular Response To Cytokine Stimulus
Negative Regulation Of Macrophage Apoptotic Process
Pathways
FCERI mediated Ca+2 mobilization
FCERI mediated Ca+2 mobilization
Binding and entry of HIV virion
Chemokine receptors bind chemokines
G alpha (i) signalling events
Interleukin-10 signaling
Drugs
Fostamatinib
Zanubrutinib
Maraviroc
AMD-070
CCR5 mAb
Leronlimab
Aplaviroc
Vicriviroc
Ibalizumab
INCB-9471
Diseases
GWAS
Aspartate aminotransferase levels (
33547301
)
Crohn's disease (
23128233
)
Mean platelet volume (
32888494
)
Multiple sclerosis (
31604244
)
Platelet distribution width (
27863252
32888494
)
Blood protein levels in cardiovascular risk (
28369058
)
Celiac disease (
20190752
)
Cerebrospinal fluid levels of Alzheimer's disease-related proteins (
25340798
)
Granulocyte percentage of myeloid white cells (
27863252
)
Inflammatory bowel disease (
26192919
)
Type 1 diabetes (
25751624
)
Ulcerative colitis (
26192919
28067908
)
Interacting Genes
38 interacting genes:
CBY2
CCDC33
CCR5
CLNK
CRK
CTLA4
DOK2
DUSP6
EFHC2
EGFR
ERBB2
ERBB3
ERBB4
FYN
GRB10
GRB2
HOMEZ
IKZF1
IKZF4
JRK
KIT
LCP2
MET
NCK2
NELFCD
PIK3R1
PRDM14
RBAK
SH2D2A
SOCS3
SOCS6
SRC
STAP2
TNS4
YTHDC1
ZNF587
ZNF792
ZNF835
43 interacting genes:
AFP
ARL6IP5
ARRB1
CCL11
CCL13
CCL14
CCL16
CCL2
CCL3
CCL3L1
CCL3L3
CCL4
CCL5
CCL7
CCL8
CD4
CST9L
CTBP2
CXCR4
DNM2
EMP1
ETV5
GNAI1
GNAI2
GNAI3
GNAO1
GNAQ
GRK2
GRK3
IL24
JAK1
JAK2
LCK
ORM1
PRAF2
PSMA5
PTK2
PTK2B
SLC20A2
STAT1
STAT3
STAT5A
TXK
Entrez ID
7294
1234
HPRD ID
02505
03223
Ensembl ID
ENSG00000074966
ENSG00000160791
Uniprot IDs
P42681
P51681
Q38L21
PDB IDs
2DM0
2L87
2MZX
2RLL
2RRS
4MBS
5UIW
5YD3
5YD4
5YD5
5YY4
6FGP
6MEO
6MET
7F1Q
7F1R
7F1S
7NJZ
7NW3
7O7F
8AS2
8AS3
Enriched GO Terms of Interacting Partners
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Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme-linked Receptor Protein Signaling Pathway
Protein Tyrosine Kinase Activity
Cell Surface Receptor Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
ERBB2 Signaling Pathway
Phosphotyrosine Residue Binding
ErbB-3 Class Receptor Binding
Transmembrane Receptor Protein Tyrosine Kinase Activity
Intracellular Signal Transduction
Basal Plasma Membrane
Leukocyte Activation
Ephrin Receptor Binding
Positive Regulation Of Phosphorylation
Protein Kinase Activity
Cell Activation
Signal Transduction
Negative Regulation Of Immune System Process
Regulation Of Programmed Cell Death
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Negative Regulation Of Programmed Cell Death
Ephrin Receptor Signaling Pathway
Receptor Complex
ERBB3:ERBB2 Complex
Peptidyl-tyrosine Phosphorylation
T Cell Activation
Protein Tyrosine Kinase Activator Activity
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
Response To Growth Factor
Positive Regulation Of Phosphate Metabolic Process
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Lymphocyte Activation
Kinase Activity
Immune System Process
Regulation Of Cell Adhesion
Schwann Cell Development
Regulation Of Cell Activation
Leukocyte Migration
Epidermal Growth Factor Receptor Activity
Positive Regulation Of Protein Phosphorylation
Neuregulin Receptor Activity
Regulation Of MAPK Cascade
Cell Motility
Immune Response-activating Cell Surface Receptor Signaling Pathway
Regulation Of Lymphocyte Activation
Scaffold Protein Binding
Antigen Receptor-mediated Signaling Pathway
Regulation Of Leukocyte Cell-cell Adhesion
Cell Migration
Chemokine-mediated Signaling Pathway
CCR Chemokine Receptor Binding
Cytokine-mediated Signaling Pathway
Chemokine Activity
G Protein-coupled Receptor Signaling Pathway
Eosinophil Chemotaxis
Eosinophil Migration
Positive Regulation Of Cell Migration
Positive Regulation Of Cell Motility
Positive Regulation Of Locomotion
Antimicrobial Humoral Response
Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Cell Chemotaxis
Cytokine Activity
CCR5 Chemokine Receptor Binding
Immune System Process
Immune Response
Cell Surface Receptor Signaling Pathway
Regulation Of Cell Migration
Humoral Immune Response
Regulation Of Cell Motility
Signal Transduction
Regulation Of Locomotion
Granulocyte Chemotaxis
Leukocyte Migration
Chemotaxis
Granulocyte Migration
Defense Response
Cell Migration
Leukocyte Chemotaxis
Inflammatory Response
Locomotion
Response To Other Organism
Response To External Biotic Stimulus
Cell Motility
Regulation Of Lymphocyte Chemotaxis
Myeloid Leukocyte Migration
Defense Response To Symbiont
Positive Regulation Of Natural Killer Cell Chemotaxis
Defense Response To Other Organism
Guanyl Nucleotide Binding
CCR1 Chemokine Receptor Binding
G Protein-coupled Receptor Binding
Positive Regulation Of Multicellular Organismal Process
Positive Regulation Of Lymphocyte Chemotaxis
Cell Surface Receptor Signaling Pathway Via STAT
Non-membrane Spanning Protein Tyrosine Kinase Activity
G-protein Beta/gamma-subunit Complex Binding
Protein Kinase Activity
Interleukin-9-mediated Signaling Pathway
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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